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1.
S.A. GEORGE D.J. BILSLAND N.J. WAINWRIGHT J. FERGUSON 《The British journal of dermatology》1993,128(3):301-305
Despite a widely held belief that the use of emollients prior to broad-band UVB irradiation accelerates clearance of psoriasis, only one single-blind controlled study exists in support of this. No similar study has been carried out with photochemotherapy (PUVA) or narrow-band UVB (311–313 nm) phototherapy. As some emollients absorb UV radiation, and thereby inhibit psoriasis clearance, there is a need to identify emollients suitable for pre-irradiation use. Coconut oil may be useful in this respect. In two randomized groups of patients with chronic plaque psoriasis undergoing either routine PUVA(n=14) or narrow-band UVB phototherapy (n=15), a single-blind controlled (half-body) study was undertaken to assess the died of pre-irradiation application of coconut oil. Patients were given PUVA twice weekly, or TL-01 therapy thrice weekly. The initial UV dose was 70% of previously determined minimal phototoxic (MPD) or minimal erythema doses (MED), with 40% incremental steps at each visit (reduced if adverse effects occurred). Psoriasis severity was scored on each side after every three treatments. No significant acceleration of psoriasis clearance was seen in either group. We do not, therefore, recommend the routine use of emollients prior to PUVA or TL-01 therapy when using near erythemogenic irradiation regimens. 相似文献
2.
E GEORGE 《Annals of the rheumatic diseases》1998,57(11):637-640
3.
TSU-YI CHUANG M.D. M.P.H. GEORGE T. EIZNER M.D. DAVID J. ELPERN M.D. JENNY L. STONE M.D. EVAN R. ARMER M.D. 《International journal of dermatology》1995,34(6):393-397
Background. It is estimated that over 100,000 new cases of squamous cell carcinoma are diagnosed in the United States annually. This number is compounded by an increasing concern over the ozone layer depletion and the continued sunbathing behavior of many individuals. This could be particularly acute in Hawaii, which may have the highest rates of skin cancer in the country. We believe the updated information on skin cancer is essential to address the magnitude of the problem. Methods. A prospective 5-year population-based incidence study was conducted on Kauai, Hawaii, between 1983 and 1987 to investigate the frequency of squamous cell carcinomas in resident Caucasians. Results. A total of 58 residents, 37 men and 21 women, were identified with an initial episode of squamous cell carcinoma during the 5-year period. The average annual incidence rate per 100,000 Kauai Caucasian residents, standardized to the 1980 U.S. white population, was 153 for men and 92 for women with a combined rate of 118. The average patient age was 66.4 years. The head and neck was the most common anatomic site, with the extremities second. Subsequent new squamous cell carcinoma occurred in 13.8% of patients. Only one patient (2%) developed a recurrence after treatment. Twenty-five patients (43%) had basal cell carcinoma simultaneously or at other earlier times. Conclusions. In Kauai the incidence rate of squamous cell carcinoma is the highest yet documented in the United States. No consistent trend in incidence rates was appreciated during this 5-year period. 相似文献
4.
A case is presented of a 16-year-old girl with ectodermal dysplasia for whom dental surgery under general anaesthesia was planned. Following a priming dose of vecuronium, and immediately after injection of sodium thiopentone (5 mg·kg−1 ) pulmonary aspiration of gastric contents occurred. It is hypothesized that, because of the rapid speed of onset of neuromuscular blocking agents on the laryngeal muscles, that partial laryngeal paralysis was present at the time of induction of anaesthesia and that this was responsible in part for the episode of pulmonary aspiration. 相似文献
5.
In a study to elucidate molecular mechanisms in pain, substance P-like immunoreactivity (SP-LI) was measured in lumbar CSF from 75 patients with lower back pain. Two samples – one before and one after lidocaine treatment – were obtained from each patient, and total SP-LI was measured in unfractionated (no HPLC) samples. SP-LI data were separated into three categories: placebo responders, pharmacological responders, and pharmacological non-responders. A significant difference was observed between the total SP-LI measurement of first and second samples of pharmacological non-responders. Distribution of SP-LI immunoreactive molecular species in two CSF patient samples (no ODS) was analyzed with a combination of reversed phase (RP) HPLC and RIA. Immunoreactivity in collected HPLC fractions was measured at calibrated retention times of synthetic SP-sulfoxide (SP-O), SP, and SP5–11. Qualitative and quantitative differences in those HPLC-RIA metabolic profiles were observed within and between those two patients' samples. These data indicate that the type and amount of SP metabolism and SP precursor-processing differs in CSF between these two representative patients and within the short amount of time elapsed between acquiring these two samples. 相似文献
6.
GEORGE STAVROPOULOS KOSTAS KARAGIANNIS PAUL CORDOPATIS DAVID HALLE CHAIM GILON GIORA BAR-AKIVA ZVI SELINGER MICHAEL CHOREV 《Chemical biology & drug design》1991,37(3):180-184
The analogues [Glu(OBzl)11]SP6–11 and [Glu(OBzl)11]SP5–11 of the C-terminal hexapeptide and heptapeptide of Substance P have been synthesized by conventional solution methods. In each analogue the SCH3 group of Met11 is replaced by the COOCH2C6H5 group. The in vitro activity of both analogues has been determined on three biological preparations: guinea pig ileum (GPI), rat vas deferens (RVD), and rat portal vein (RPV). The selectivity for the different receptors has been studied by utilizing atropine-treated guinea pig ileum (GPI + At). The results showed that both analogues are mainly active on GPI through the NK-1 receptor and that both analogues are equipotent to Substance P. 相似文献
7.
EVELYNE GOUDREAU M.D. GEORGE W. VETROVEC M.D. GERMANO DISCIASCIO M. D. 《Journal of interventional cardiology》1988,1(3):181-187
Different techniques have been used to perform coronary angioplasty of bifurcational lesions. Advantages and disadvantages of the kissing balloon technique, the single guiding-double wire technique, and the double Probe(tm) technique are reviewed. We describe a new technique for coronary angioplasty of bifurcational lesions through a single guiding catheter that has advantages of both the over-the-wire and the Probe(tm) systems. 相似文献
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10.
BURROWS FREDERICK A.; VOLGYESI GEORGE A.; JAMES PETER D. 《British journal of anaesthesia》1989,63(5):565-573
To assess the augmented delta quotient (ADQ) monitor as a monitorof cerebral function during cardiac surgery, we monitored duringoperation the electroencephalograms of 48 young subjects (aged2 weeks to 19 yr). We found ADQ patterns produced by cardiopulmonarybypass, hypothermia and general anaesthetic agents correlatedwith those obtained from a compressed spectral array (CSA) monitorand could be differentiated from changes caused by cerebralischaemia, except in the youngest group of patients ( 18 months)undergoing deep hypothermia (19.4 (SD 0.8) °C nasopharyngeal).In all other age groups the ADQ proved to be a simple monitorof the adequacy of cerebral perfusion. Neurological deficitoccurred only if the ADQ was abnormal during hypotension fora period exceeding 7 min. ADQ evaluation of cerebral functionwas limited by events which produced artificially normal ADQreadings such as low amplitude EEG activity and the describedisoflurane effect that was demonstrated to occur in some cardiacpatients. The results obtained by the ADQ were comparable tothose obtained by compressed spectral array and the ADQ waseasier to use and interpret.
*Present address: Department of Anaesthesia and Intensive Care,Basingstoke District Hospital, Basingstoke, Hants. 相似文献