Die infizierte Gelenkendoprothese

Trauma und Berufskrankheit - Als schwerste Komplikation der Gelenkendoprothetik bleibt die periprothetische Infektion eine Herausforderung—heutzutage nicht nur für den Chirurgen, sondern...     

A review of child psychotherapy research since 1963.

Reports on individual nonbehavioral child and adolescent psychotherapy since 1963 are reviewed. Inclusion criteria required some minimal contrasting group. Forty-three studies were assessed for basic methodological adequacy and main findings. The authors conclude that summary impressions from this body of literature cannot be made due to the magnitude of the flaws in basic psychotherapy research methodology. Suggestions are made regarding the future of child and adolescent psychotherapy research.     

Vorschlag für eine Konsensus-Klassifikation der periprothetischen Membran gelockerter Hüft- und Knieendoprothesen

After 10 years, loosening of total joint endoprostheses occurs in about 3 to 10 percent of all patients, requiring elaborate revision surgery. A periprosthetic membrane is routinely found between bone and loosened prosthesis. Further histomorphological examination allows determination of the etiology of the loosening process. Aim of this study is the introduction of clearly defined histopathological criteria for a standardized evaluation of the periprosthetic membrane. Based on histomorphological criteria and polarized light microscopy, four types of the periprosthetic membrane were defined: periprosthetic membrane of wear particle type (type I), periprosthetic membrane of infectious type (type II), periprosthetic membrane of combined type (type III), periprosthetic membrane of indifferent type (type IV). Periprosthetic membranes of 268 patients were analyzed according to the defined criteria. The correlation between histopathological and microbiological diagnosis was high (89%, p<0,001), the inter-observer reproducibility was sufficient (95%). This classification system enables a standardized diagnostic procedure and therefore is a basis for further studies concerning the etiology of and pathogenesis of prosthesis loosening.     

Cerebral beta amyloid angiopathy is a risk factor for cerebral ischemic infarction. A case control study in human brain biopsies

Cerebral amyloid angiopathy (CAA) is conspicuous for its association with Alzheimer disease (AD) and as a cause of lobar hemorrhages in the elderly, but its role in cerebral infarction is less clear. There is evidence that CAA may also be a risk factor for ischemic infarction in AD. To further investigate CAA as a risk factor for infarction, we studied 108 cases of recent cerebral or cerebellar infarction diagnosed in tissue samples obtained from surgical material. There were 69 males and 39 females with a mean age of 52 yr (range 1-86). The majority of biopsies were obtained from the frontal and parietal lobes. Radiological studies demonstrated a lesion confined to a vascular distribution in 12 of the 17 (71%) cases examined. Microscopic sections stained with hematoxylin and eosin revealed complete, organizing infarction in 107 cases with areas of coagulative necrosis, anoxic-ischemic neuronal injury, inflammation, macrophages, vascular proliferation, gliosis, and swollen axons. One case showed an incomplete infarct. Most cases also exhibited a minor hemorrhagic component with hemosiderin and hematoidin pigments. CAA, defined as amyloid deposition in the walls of leptomeningeal and parenchymal arteries, was found by immunohistochemical stains for beta amyloid in 14 (13%) cases of complete cerebral infarct. Cortical beta amyloid plaques were found by immunohistochemistry in 19 (17%) cases. Cerebral or cerebellar tissues containing cortex and leptomeninges obtained from 136 patients with a mean age of 52 yr (range 1-85) during surgical procedures for diagnosis of primary or metastatic neoplasms and demyelinating lesions were used as age-matched controls. In this control group, CAA was found in 5 (3.7%) and beta amyloid plaques in 19 (14%). The results indicate that CAA, but not beta amyloid plaque formation, is significantly more common in patients with ischemic cerebral infarction than in age-matched controls with nonvascular lesions (odds ratio 3.8; 95% confidence interval 1.3-10.9; p < 0.01). Our results indicate that CAA is a risk factor for ischemic cerebral infarction in the population studied.     

Intraoperative Transgastric Echo Assessment During Left Ventricular Outflow Tract Surgery: A Reliable Predictor of Residual Obstruction

Standard transesophageal echocardiography (TEE) views of the left ventricular outflow tract (LVOT) are limited by poor Doppler beam alignment with the peak velocity of flow. Transgastric imaging allows well-aligned continuous-wave Doppler interrogation of the LVOT and was attempted during intraoperative TEE in all children undergoing LVOT surgery at Children's Hospital of Wisconsin. Thirty-eight patients, ranging in age from 2 days to 18 years (median, 5.2 years) and in weight from 2.9 to 100 kg (median, 16.7 kg), had TEE during surgery to resect membranous or fibromuscular subaortic obstruction (20 patients), valvuloplasty for aortic stenosis/insufficiency (13 patients), aortoplasty for supravalvar stenosis (one patient), or repair/replacement for aortic insufficiency (four patients). In four patients, transgastric images of the LVOT could not be obtained. Intraoperative Doppler gradients identified severe residual obstruction (mean, 67 +/- 13.5 mmHg) after surgery in seven patients; six of these patients underwent immediate repeat operation with subsequent adequate relief, and one patient required later aortoventriculoplasty for persistent annular/valvar obstruction. All other patients had successful LVOT reconstruction with intraoperative Doppler gradients ranging from 0 to 46 mmHg, and none required early repeat operation. Good correlation was found between the intraoperative transgastric gradient (mean, 25.8 +/- 17.7 mmHg) and the early postoperative transthoracic echo gradient (mean, 21.8 +/- 21.4 mmHg). In addition, there was consistent agreement in the assessment of aortic insufficiency between the transesophageal and transthoracic studies. We conclude that transgastric Doppler assessment of the LVOT is a critical component of intraoperative monitoring during LVOT surgery and is a reliable predictor of residual obstruction.     

Receptor activator of nuclear factor kappaB ligand is expressed in resident and inflammatory cells in aseptic and septic prosthesis loosening

OBJECTIVE: The pathogenesis of periprosthetic bone loss in aseptic and septic prosthesis loosening is unclear. There is considerable evidence that macrophages and osteoclasts play a key role in focal bone erosion and osteolysis around the prosthesis. RANKL (receptor activator of nuclear factor kappaB ligand) was shown to be a potent osteoclastogenic factor, and to be involved in bone destruction of myeloma and rheumatoid arthritis patients. Osteoprotegerin (OPG) is the natural RANKL inhibitor and may prevent periprosthetic bone loss. METHODS: The presence and distribution of RANKL, its receptor RANK and OPG in the periprosthetic interface of septically (n = 5) and aseptically (n = 6) loosened prostheses was examined by immunohistochemistry and immunoblotting. Additionally, the immunophenotype of the inflammatory infiltrate was determined [CD3, CD68, Ki-67, tartrate-resistant acid posphatase (TRAP)]. RESULTS: Aseptic and septic cases revealed a different histopathologic pattern. However, in all cases RANKL and RANK could be demonstrated in macrophages and giant cells. In addition, RANKL detected by immunoblot analysis proved to have the same molecular weight as a recombinant RANKL used as a control (31 kD and approximately 48 kD). OPG was detected in aseptic loosening, where macrophages showed a strong staining, but multinucleated giant cells were only weakly stained. A weak OPG staining was also observed in septic loosening. CONCLUSION: The pathogenesis of bone loss in septic loosening remains unclear, because the septic membrane bears few macrophages and giant cells, and half of them express OPG. In aseptic loosening, macrophages might not be stimulated by RANKL as a result of OPG expression. But multinucleated giant cells may be activated, as they hardly express OPG. They might be responsible for periprosthetic bone loss in aseptic loosening as a result of their RANKL and RANK expression.     

Einfluss Der Ultravioletten Strahlen auf die Zahl der Reticulocyten Im Blut

Zusammenfassung In Fortführung früherer Untersuchungen über die Frühjahrsreticulocytose wurde jetzt das Verhalten der Reticulocytenwerte im strömenden Blut unter dem Einfluß von Bestrahlungen mit künstlicher Höhensonne in der Winterzeit geprüft. Die Bestrahlungen wurden mit steigenden und ziemlich hohen Dosen bis zur Höchstdosis von 46,8 Einheitsminuten (15 Minuten Bestrahlungsdauer bei Lampenabstand von 80 cm von Brust und Rücken) durchgeführt. Die Bestrahlungsserie umfaßte 10 Einzelbestrah-Iungen und wurde im Laufe etwa eines Monats durchgeführt. Während der Bestrahlung trat regelmäßig ein Reticulocytenanstieg ein, wobei der Höchstwert in die Zeitspanne der ersten 6 Bestrahlungen fiel. In der Folgezeit sanken die Werte trotz Fortsetzung der Bestrahlungen und Beibehaltung der Dosierung wieder ab.Im Zusammenhang mit den erzielten Untersuchungsergebnissen wird eine Reihe von Fragen, wie z. B. Höhe der wirksamen Strahlendosis, Summationswirkung der u.v. Strahlen, individuelle Reaktionsbereitschaft für diese Strahlen gestreift.     

Consequence of European Directive 2004/23/EC for bone banks in Germany

Allogenic bone grafting is an established method in revision surgery of artificial joint replacement and spinal surgery in case of bone defects. In Germany, femoral heads from living donors undergoing total hip replacement are frequently used. These grafts are processed according to the "Guidelines for the management of bone banking" issued by the Federal Medical Board. Bone grafts are drugs according to German law. Local bone banks are excluded from the regulations of the federal law on drugs [Arzneimittelgesetz (AMG) section sign 4a (4)] if certain requirements are fulfilled.The Directive 2004/23/EC of the European Parliament and of The Council on Setting Standards of Quality and Safety for the Donation, Procurement, Testing, Processing, Preservation, Storage and Distribution of Human Tissues and Cells has to be implemented into national law within 2 years. The exception of section sign 4a (4) will no longer be possible. Thus a legal construction has to be found which allows running local bone banks in compliance with the new legal settings. Three conditions will be possible: (1) a single physician procures a graft for another patient of his, (2) grafts are procured in one hospital and are used exclusively in this hospital: a license from the local authorities and a strict quality assessment according to GMP-rules is required, (3) if the grafts are distributed to other hospitals, a license from the local authorities and registration as a drug by the federal authorities are necessary.     

One-stage revision of shoulder arthroplasty in the case of periprosthetic infection

AIM: Infection of shoulder arthroplasties is rare, but represents a potentially devastating complication. The aim of this work is to show the value of various diagnostic procedures, specify causative pathogens and present the results of one-stage revised patients. METHOD: We performed a retrospective analysis of our 16 consecutive patients with an infected shoulder arthroplasty. RESULTS: In 13 of 16 cases a causative pathogen could be established preoperatively. Staphylococcus and Propioni spp. dominated. Only 9 patients could be followed up because two died, two were lost and three patients were revised because of non-infectious complications. The follow-up time was 5.8 years (13 months-13.25 years). The Constant-Murley score was 33.6 of 100. Eradication of infection was achieved in all patients. In the follow-up time no reinfection has occurred. CONCLUSION: Culturing of the preoperative joint fluid aspirate and the determination of CRP provide an early diagnosing of shoulder arthroplasty infection. One-stage revision arthroplasty with radical debridement and application of antibiotics to the bone cement provide an accurate therapy of periprosthetic shoulder infection.     

Prinzipien der Antibiotikabehandlung bei periprothetischen Infektionen

Periprosthetic infection is nowadays a rare complication in artificial joint replacement. The infection of joint prostheses is a foreign body associated infection at the site of bone tissue which is difficult to treat with antimicrobial agents. Apart from cases with early, non-established infections, the surgical removal of the foreign material and radical débridement of bone and soft tissue is necessary. The surgical revision is performed preferentially using a one or two stage exchange of the prosthesis. In some cases, only the removal of the prosthesis is necessary. In these cases, a pseudoarthroplasty or an arthrodesis without definitely implanted foreign material is performed. Amputation is carried out if all other forms of revision have failed. All of these surgical procedures are accomplished by antimicrobial therapy, whether systemically administered and/or topically by drug delivery systems. Controlled studies for the comparison of one and two stage exchange procedures are not currently available. For the therapy of periprosthetic infection, an infectious disease specialist who is experienced in this area is needed in addition to an experienced surgical team. Thus, the therapy of these infections should be performed exclusively in centres of competence.