Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative,two new compounds isolated from Terminalia bellirica

Journal of Natural Medicines - Two new compounds, thannilignan 9-O-β-glucoside (1) and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from...     

室间隔折叠治疗左室前壁并前间隔巨大室壁瘤

目的:评价室间隔折叠加Dor或Cooley术式治疗心肌梗死后左室前壁并前间隔巨大室壁瘤的效果。方法:23例心肌梗死后左室前壁并前间隔巨大室壁瘤采用室间隔折叠、前壁室壁瘤行Dor或标准线性缝合术,同期行冠状动脉搭桥术,对比患者术前、出院前、术后3个月的心功能NYHA分级、舒张末期容积指数(LVEDVI)、收缩末期容积指数(LVESVI),左室射血分数(LVEF)值。结果:与术前相比,出院前、术后3个月NYHA分级从3.21±0.62分别提高到1.72±0.31和1.57±0.23(P<0.05),LVEDVI从(102.31±18.71)mL/m2分别减少到(62.11±6.21)mL/m2和(54.63±4.54)mL/m2(P<0.05),LVESVI从(69.32±17.48)mL/m2分别减少到(30.23±3.25)mL/m2和(28.34±3.12)mL/m2,LVEF从(32.92±8.12)%分别提高到(48.78±4.51)%和(50.52±4.68)%(P<0.05)。结论:冠心病左室前壁并前间隔巨大室壁瘤室间隔采用折叠术、前壁室壁瘤行Dor或标准线性缝合术能明显改善左心室功能。     

Acacienone,a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leaves

Journal of Natural Medicines - A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by...     

Eudesmane-Type Sesquiterpenoid and Guaianolides from Kandelia candel in a Screening Program for Compounds to Overcome TRAIL Resistance

In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A-C (2-4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3-6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.     

Search for bioactive natural products from medicinal plants of Bangladesh

In our continuous search for bioactive natural products from natural resources, we explored medicinal plants of Bangladesh, targeting cancer-related tumor necrosis factor-related apoptosis-inducing ligand-signaling pathway, along with some other biological activities such as prostaglandin inhibitory activity, 1,1-diphenyl-2-picrylhydrazyl free-radical-scavenging activity, and cell growth inhibitory activity. Along with this, we describe a short field study on Sundarbans mangrove forests, Bangladesh, in the review.     

Tyrosine derivatives isolated from Streptomyces sp. IFM 10937 in a screening program for TRAIL-resistance-overcoming activity

Exploration of actinomycetes for isolation of natural products for abrogating TRAIL resistance led to the isolation of two new tyrosine derivatives (1 and 2) along with novobiocin (3). The structures of 1 and 2 were determined by spectroscopic methods, while the absolute configuration was determined by analyzing CD spectra and by a modified Marfey's method. Compounds 1 (150 μM) and 3 (37.5 and 75 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.     

Flavonoids from Sonneratia caseolaris

According to the traditional medicinal usage of Sonneratia caseolaris, we tested the extract of S. caseolaris for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect on thin-layer chromatography. Following activity-oriented separation, two flavonoids, luteolin (1) and luteolin 7-O--glucoside (2), were isolated. Both of the compounds were found to possess antioxidant activity.