全文获取类型
收费全文 | 4419篇 |
免费 | 246篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 141篇 |
妇产科学 | 216篇 |
基础医学 | 552篇 |
口腔科学 | 224篇 |
临床医学 | 280篇 |
内科学 | 1014篇 |
皮肤病学 | 57篇 |
神经病学 | 597篇 |
特种医学 | 104篇 |
外国民族医学 | 1篇 |
外科学 | 554篇 |
综合类 | 10篇 |
预防医学 | 176篇 |
眼科学 | 36篇 |
药学 | 248篇 |
中国医学 | 7篇 |
肿瘤学 | 445篇 |
出版年
2023年 | 29篇 |
2022年 | 44篇 |
2021年 | 105篇 |
2020年 | 63篇 |
2019年 | 78篇 |
2018年 | 87篇 |
2017年 | 78篇 |
2016年 | 88篇 |
2015年 | 108篇 |
2014年 | 156篇 |
2013年 | 188篇 |
2012年 | 289篇 |
2011年 | 321篇 |
2010年 | 146篇 |
2009年 | 153篇 |
2008年 | 245篇 |
2007年 | 281篇 |
2006年 | 260篇 |
2005年 | 252篇 |
2004年 | 252篇 |
2003年 | 190篇 |
2002年 | 167篇 |
2001年 | 91篇 |
2000年 | 125篇 |
1999年 | 111篇 |
1998年 | 35篇 |
1997年 | 29篇 |
1996年 | 33篇 |
1995年 | 27篇 |
1994年 | 28篇 |
1993年 | 30篇 |
1992年 | 59篇 |
1991年 | 66篇 |
1990年 | 56篇 |
1989年 | 43篇 |
1988年 | 36篇 |
1987年 | 37篇 |
1986年 | 31篇 |
1985年 | 33篇 |
1984年 | 21篇 |
1983年 | 21篇 |
1981年 | 15篇 |
1979年 | 23篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1975年 | 16篇 |
1973年 | 13篇 |
1970年 | 10篇 |
1969年 | 16篇 |
1967年 | 12篇 |
排序方式: 共有4685条查询结果,搜索用时 15 毫秒
1.
Wojciech Szychta M.D. Ph.D. Gheorghe Cerin M.D. Ph.D. F.E.S.C. Bogdan Adrian Popa M.D. Armienti Felice M.D. Guido Lanzillo M.D. Ph.D. Marco Diena M.D. Grzegorz Opolski M.D. Ph.D. F.E.S.C. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(6):1040-1043
Sinus venosus atrial septal defect (SV‐ASD) usually coexists with partial anomalous pulmonary vein connection (PAPVC). It is a difficult diagnosis in transthoracic echocardiography (TTE) due to eccentric position of defects. We present a rare case of atypical anatomical variation in PAPVC, which was never described before. Two right pulmonary veins drained into superior vena cava, which overrode SV‐ASD and interatrial septum, a third pulmonary vein into the right atrium. Complete diagnosis could not be set after TTE, nor transesophageal echocardiography, whereas angio‐CT was finally conclusive. This diagnostic approach allowed the surgical planning. 相似文献
2.
F. Murina R. Felice S. Di Francesco L. Nelvastellio I. Cetin 《Gynecological endocrinology》2020,36(5):431-435
AbstractThis study is a single-center, retrospective analysis of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60?mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene?+?laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene?+?laser group compared with the laser treatment group (?87% vs???34%, respectively), and the vestibular health score started declining faster in the ospemifene?+?laser group. Although, additional research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clinical effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. 相似文献
3.
4.
Erdosteine was introduced in the market as a mucolytic agent for chronic pulmonary diseases more than 10 years ago. The drug contains two blocked sulphydryl groups one of which, after hepatic metabolization and opening of the thiolactone ring, becomes available both for the mucolytic and free radical scavenging and antioxidant activity too. There are several experimental evidences which support the protective effect of erdosteine in acute injury induced by a variety of pharmacological or noxious agents, mediated by products of oxidative stress. Experimental data in animal assigned to receive the noxious agent evidence that co-treatment with erdosteine increases the tissue antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase, compared with the toxic agent alone; meanwhile erdosteine decreases the tissue level of nitric oxide, xanthine oxidase, which catalyze oxygen-free radical production. In summary, erdosteine prevents the accumulation of free oxygen radicals when their production is accelerated and increases antioxidant cellular protective mechanisms. The final result is a protective effect on tissues which reduces lipid peroxidation, neutrophil infiltration or cell apoptosis mediated by noxious agents. Recent positive clinical trials in humans seem to fulfill the impressive promises that theory and experimental research have put forward. 相似文献
5.
6.
Nicola Martinelli Domenico Girelli Paolo Ferraresi Oliviero Olivieri Barbara Lunghi Franco Manzato Roberto Corrocher Francesco Bernardi 《Blood coagulation & fibrinolysis》2007,18(2):125-129
A common factor V gene haplotype, the FVR2 haplotype (FVHR2), has been associated with a reduced cofactor activity in activated protein C-mediated activated factor VIII inactivation. Our aim was to investigate the role of FVHR2 as a possible determinant of factor VIII levels in a population study. A total of 516 individuals (401 men, 115 women; mean age 58.4 +/- 10.8 years) were enrolled within the frame of a regional cardiovascular survey, characterized for factor VIII coagulant activity (FVIII:c) and factor V coagulant activity (FV:c) levels, and genotyped for factor V polymorphisms. In men without signs of overt inflammation, FVHR2 carriers had higher levels of FVIII:c than noncarriers (154 IU/dl, 95% confidence interval = 143-166 versus 142 IU/dl, 95% confidence interval = 138-147; P = 0.045) and were more represented in individuals with high (> or = 150 IU/dl) FVIII:c levels (21.2 versus 10.8%; odds ratio = 2.27, 95% confidence interval = 1.17-4.39 after adjustment for age, blood group and high-sensitivity C-reactive protein levels). In conclusion, this clinical report suggests the common FVHR2 as a possible independent determinant of FVIII:c levels. The report concomitantly addresses the relationship between factor V and factor VIII levels and supports the hypothesis of a mild prothrombotic role of FVHR2 by means of increased factor VIII levels. 相似文献
7.
8.
9.
M. Filippi A. Campi V. Martinelli C. Pereira G. Scotti G. Comi 《Acta neurologica Scandinavica》1995,92(2):178-182
Transitional progressive multiple sclerosis (MS) is quite an unusual form of presentation and course of the disease. A case with this progressive form is presented and brain MRI and MTI findings are discussed in relation to the possible insight they may provide for understanding the mechanisms that determine progressive disability in MS. 相似文献
10.