全文获取类型
收费全文 | 12311篇 |
免费 | 934篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 102篇 |
儿科学 | 464篇 |
妇产科学 | 423篇 |
基础医学 | 1486篇 |
口腔科学 | 212篇 |
临床医学 | 1404篇 |
内科学 | 2186篇 |
皮肤病学 | 134篇 |
神经病学 | 1024篇 |
特种医学 | 515篇 |
外科学 | 2031篇 |
综合类 | 240篇 |
一般理论 | 8篇 |
预防医学 | 1121篇 |
眼科学 | 314篇 |
药学 | 863篇 |
中国医学 | 32篇 |
肿瘤学 | 709篇 |
出版年
2021年 | 174篇 |
2020年 | 117篇 |
2019年 | 159篇 |
2018年 | 200篇 |
2017年 | 147篇 |
2016年 | 151篇 |
2015年 | 166篇 |
2014年 | 221篇 |
2013年 | 410篇 |
2012年 | 507篇 |
2011年 | 614篇 |
2010年 | 287篇 |
2009年 | 302篇 |
2008年 | 565篇 |
2007年 | 611篇 |
2006年 | 644篇 |
2005年 | 569篇 |
2004年 | 570篇 |
2003年 | 485篇 |
2002年 | 534篇 |
2001年 | 328篇 |
2000年 | 326篇 |
1999年 | 317篇 |
1998年 | 194篇 |
1997年 | 137篇 |
1996年 | 143篇 |
1995年 | 118篇 |
1994年 | 108篇 |
1993年 | 111篇 |
1992年 | 222篇 |
1991年 | 212篇 |
1990年 | 207篇 |
1989年 | 175篇 |
1988年 | 181篇 |
1987年 | 161篇 |
1986年 | 173篇 |
1985年 | 169篇 |
1984年 | 173篇 |
1983年 | 161篇 |
1982年 | 116篇 |
1981年 | 113篇 |
1980年 | 93篇 |
1979年 | 136篇 |
1978年 | 117篇 |
1977年 | 110篇 |
1976年 | 89篇 |
1975年 | 103篇 |
1974年 | 105篇 |
1973年 | 112篇 |
1972年 | 95篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
Juliette A. Loncaster MD FRCR Ernest Allan 《Photodiagnosis and Photodynamic Therapy》2006,3(2):134-137
Gorlin syndrome (naevoid basal cell carcinoma syndrome) is a genetically linked disorder characterized by the development of multiple basal cell carcinomas (BCCs) throughout life. Cumulative surgery, cryotherapy and other conventional interventions can result in significant disfigurement by middle age. Radiotherapy is contra-indicated because the mutated gene underlying the syndrome, ‘PTCH’, increases sensitivity to ionising radiation, so there is significant likelihood of inducing further tumours in and around the irradiated area. Photodynamic therapy offers a non-invasive treatment option for patients with this condition, with the added advantage of causing minimal scarring. 相似文献
4.
5.
Kevin L Taylor Rhonda K Oates Ron Grane Douglas W Leaman Ernest C Borden Daniel J Lindner 《Journal of interferon & cytokine research》2006,26(5):353-361
Interferon-alpha (IFN-alpha) has proved effective in the treatment of hemangiomas, hemangioblastomas, and Kaposi's sarcoma. To investigate the ability of IFNs to inhibit angiosarcoma, we used two transformed murine endothelial cell lines that form angiosarcomas in vivo. SVR and MS1-VEGF cell lines express oncogenic H-ras or vascular endothelial growth factor (VEGF), respectively. IFN-alpha1,8, which is active against murine and human cells, inhibited SVR and MS1-VEGF proliferation in vitro by 40% at 10(3) U/mL (p = 0.028). In vivo, IFN-alpha1,8 inhibited SVR tumor volume by 71% (p = 0.047) and MS1-VEGF volume by 79% (p = 0.003). Tumor-induced angiogenesis was decreased in SVR tumors by 52% (p = 0.005) and in MS1-VEGF tumors by 58% (p = 0.001). Sera from IFN-alpha1,8-treated mice bearing either SVR or MS1-VEGF tumors demonstrated a 5-fold increase in IP-10/CXCL10 (p = 0.001), an IFN-induced antiangiogenic protein. Both recombinant IP-10 and IFN-alpha1,8 inhibited human umbilical vein endothelial cell (HUVEC) vessel formation in the fibrin gel assay, a three-dimensional culture model of angiogenesis, by 56% at 25 ng/mL and 50% at 1.2 ng/mL, respectively (p < 0.001). An IP-10 blocking antibody restored vessel formation to 80% of untreated controls (p = 0.001). Given the magnitude of the in vivo response, these data suggested that the antitumor effects of IFN-alpha1,8 were likely mediated through angiogenesis inhibition rather than solely by direct inhibition of tumor cell proliferation. 相似文献
6.
7.
R. Jayasuriya V. Westley-Wise T. Dunn K. Nydam D. Jeffs 《Internal medicine journal》1993,23(6):672-677
Background: The management and follow-up of asthma patients presenting at Accident and Emergency (A&E) departments have mostly been studied in children's hospitals or specialised teaching hospitals. Aims: To study the adequacy of assessment, treatment and follow-up of patients presenting at A&E departments in non-teaching hospitals. Methods: A twenty-five per cent sample of presentations to A&E departments in all public hospitals in the Illawarra for one year was selected for a case note audit. Information on demographics, assessment, management and referral was extracted from the A&E case notes and medical records of cases with documentation of a final diagnosis of asthma. Chi square and Fischer's Exact tests were used for comparisons among hospitals. Results: Of 359 presentations with a final diagnosis of asthma, 88% were self referred and only 5% were first presentations. Objective measures of airways obstruction was not documented in 34% of admissions and 48% of nonadmissions. There was no documented follow-up in 28% of cases. The assessment and management of asthma in A&E was significantly poorer in smaller hospitals. Conclusion: Evidence of high use of A&E as a primary care facility by asthma patients was found in the study. There is a need to implement protocols to optimise assessment and treatment of asthma in smaller hospitals. (Aust NZ J Med 1993; 23: 672–677.). 相似文献
8.
Timothy J Halligan Nathan G Russell William J Dunn Steven J Caldroney Timothy B Skelton 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2005,100(6):688-692
Scurvy is a nondiscriminatory disease process resulting from a nutritional deficiency of ascorbic acid (vitamin C). The severe vitamin deficiency produces a breakdown in the cellular structure of the body. This case report describes a middle-age woman with a history of edema, bruising of the lower extremities, anemia, and severe periodontal disease. Her presentation and medical history are classic for the signs of scurvy. Scurvy is now only uncommonly seen in developed countries, but there are still vulnerable populations whose nutritional status can lead to scurvy. The aim of this report is to help the clinician identify and treat scurvy, a disease that was once feared for its high mortality but is now easily treatable, even in cases that have progressed to multiple organ dysfunction and failure. 相似文献
9.
10.
D. W. Barnes, D. A. Sirbasku & G. H. Sato, (eds.): Cell culture methods for molecular and cell biology. P. M. Gootman (ed.): Developmental neurobiology of the autonomic nervous system. M. Sandler, C. Feuerstein, B. Scatton (eds.): Neurotransmitter interactions in the basal ganglia. Harry M. Zimmerman (ed). Progress in neuropathology. M. Yahr & K. J. Bergmann (eds.): Parkinson's disease. G. Bock & M. O'Connor (eds.): Selective neuronal death. H. Julia Hannay (ed.): Experimental techniques in human neuropsychology. D. Papakostopoulos, S. Butler, I. Martin (eds.): Clinical and experimental neuropsychophysiology J. C. Rothwell: Control of human voluntary movement. 相似文献