收费全文 | 95022篇 |
免费 | 6187篇 |
国内免费 | 745篇 |
耳鼻咽喉 | 1091篇 |
儿科学 | 2911篇 |
妇产科学 | 2362篇 |
基础医学 | 12805篇 |
口腔科学 | 2140篇 |
临床医学 | 7803篇 |
内科学 | 20731篇 |
皮肤病学 | 2025篇 |
神经病学 | 8913篇 |
特种医学 | 3686篇 |
外国民族医学 | 23篇 |
外科学 | 13304篇 |
综合类 | 1651篇 |
一般理论 | 51篇 |
预防医学 | 5616篇 |
眼科学 | 1562篇 |
药学 | 7785篇 |
3篇 | |
中国医学 | 511篇 |
肿瘤学 | 6981篇 |
2023年 | 422篇 |
2022年 | 998篇 |
2021年 | 1786篇 |
2020年 | 1167篇 |
2019年 | 1661篇 |
2018年 | 2055篇 |
2017年 | 1576篇 |
2016年 | 1639篇 |
2015年 | 1884篇 |
2014年 | 2488篇 |
2013年 | 3668篇 |
2012年 | 4906篇 |
2011年 | 5079篇 |
2010年 | 3267篇 |
2009年 | 2878篇 |
2008年 | 4448篇 |
2007年 | 4629篇 |
2006年 | 4414篇 |
2005年 | 4232篇 |
2004年 | 4553篇 |
2003年 | 4400篇 |
2002年 | 4459篇 |
2001年 | 3701篇 |
2000年 | 3650篇 |
1999年 | 2951篇 |
1998年 | 1125篇 |
1997年 | 884篇 |
1996年 | 814篇 |
1995年 | 787篇 |
1994年 | 685篇 |
1993年 | 668篇 |
1992年 | 1774篇 |
1991年 | 1747篇 |
1990年 | 1486篇 |
1989年 | 1432篇 |
1988年 | 1322篇 |
1987年 | 1174篇 |
1986年 | 1163篇 |
1985年 | 1035篇 |
1984年 | 763篇 |
1983年 | 693篇 |
1982年 | 448篇 |
1981年 | 385篇 |
1979年 | 566篇 |
1978年 | 416篇 |
1975年 | 429篇 |
1974年 | 479篇 |
1973年 | 463篇 |
1972年 | 422篇 |
1971年 | 393篇 |
Interstitial lung disease (ILD) represents a significant cause of morbidity and mortality in systemic sclerosis (SSc). The purpose of this study was to examine recirculating lymphocytes from SSc patients for potential biomarkers of interstitial lung disease (ILD). Peripheral blood mononuclear cells (PBMCs) were isolated from patients with SSc and healthy controls enrolled in the Vanderbilt University Myositis and Scleroderma Treatment Initiative Center cohort between 9/2017–6/2019. Clinical phenotyping was performed by chart abstraction. Immunophenotyping was performed using both mass cytometry and fluorescence cytometry combined with t-distributed stochastic neighbor embedding analysis and traditional biaxial gating. This study included 34 patients with SSc-ILD, 14 patients without SSc-ILD, and 25 healthy controls. CD21lo/neg cells are significantly increased in SSc-ILD but not in SSc without ILD (15.4 ± 13.3% vs. 5.8 ± 0.9%, p = 0.002) or healthy controls (5.0 ± 0.5%, p < 0.0001). While CD21lo/neg B cells can be identified from a single biaxial gate, tSNE analysis reveals that the biaxial gate is comprised of multiple distinct subsets, all of which are increased in SSc-ILD. CD21lo/neg cells in both healthy controls and SSc-ILD are predominantly tBET positive and do not have intracellular CD21. Immunohistochemistry staining demonstrated that CD21lo/neg B cells diffusely infiltrate the lung parenchyma of an SSc-ILD patient. Additional work is needed to validate this biomarker in larger cohorts and longitudinal studies and to understand the role of these cells in SSc-ILD.
相似文献Methods: Prospective cross-sectional study.
Results: Twenty-seven of 106 patients had positive PCR and/or GWC results on aqueous humor (AH) sampling and 15 of 27 (55.6%) were HIV-positive. Patients with non-anterior uveitis (NAU) were more likely to be HIV+ (p = 0.005). More than 1 possible pathogen was identified in 9 of 27 patients of whom 7 were HIV+. The final clinical diagnosis was discordant with AH findings in 9 of 27 cases. A positive EBV PCR result was associated with a discordant diagnosis (p = 0.001). All cases of herpetic anterior uveitis (42.9% HIV+) tested PCR-/GWC+ while all cases of herpetic NAU tested PCR+/GWC- (83.3% HIV+). All rubella virus cases were PCR+/GWC+.
Conclusion: PCR is useful to diagnose herpetic NAU in HIV+ patients while GWC is useful to diagnose herpetic anterior uveitis. 相似文献
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
![点击此处可从《Neuromodulation》网站下载免费的PDF全文](/ch/ext_images/free.gif)