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1.
Haemodilution induces a hypercoagulable state 总被引:10,自引:3,他引:7
It has been suggested that haemodilution with saline may increase whole
blood coagulation. This study was conducted in two parts. First, we
investigated the effect of in vitro dilution of blood with saline on whole
blood coagulation as measured by the thrombelastogram (TEG). Blood (4 ml)
was diluted with 0.9% saline 1 ml and coagulation compared with that of an
undiluted control specimen obtained concurrently from the same subject. In
the second part, the study was repeated using a modified gelatin colloidal
solution (Haemaccel) as the diluent. The r time, k time and r + k time were
decreased relative to control in both diluent groups. The alpha angles were
increased compared with control in both groups while maximum amplitude was
unchanged in the Haemaccel diluted group. We conclude that haemodilution
per se increases the coagulability of whole blood in vitro, but that saline
haemodilution has a more marked effect on final clot strength.
相似文献
2.
D. J. Schendel Ralph Oberneder Christine S. Falk Petra Jantzer Susanne Kressenstein Barbara Maget Alfons Hofstetter Gert Riethmüller Elfriede Nößner 《Journal of molecular medicine (Berlin, Germany)》1997,75(6):400-413
Renal cell carcinomas belong to the small group of tumors that are able to induce antitumor responses. Here we describe two
general types of cytotoxic effector lymphocytes that can eliminate autologous tumor cells and discuss the role that major
histocompatibility complex encoded molecules play in governing their specificities. Improved understanding of the cellular
and molecular basis of renal cell carcinoma recognition opens new avenues of research with the potential to develop better
immunotherapies for patients with metastatic disease.
Received: 24 July 1996 / Accepted: 1 November 1996 相似文献
3.
Incidence of esophageal carcinoma With more than 300 000 new cases per year, cancerof the esophagus, predominantly squamous cell carcinoma(SCC), is one of the 10 most frequently diagnosed tumortypes. Esophageal cancer occurs often in developing coun-tries and shows great regional di?erences[1]. While in re-cent history the incidence of SCC has decreased slightly inregions of high risk and stayed constant in the USA andWestern Europe, the rate of adenocarcinoma of the esoph-agus (AC) has… 相似文献
4.
5.
P. Weidmann R. de Chatel Annamarie Schiffmann Elfriede Bachmann C. Beretta-Piccoli F. C. Reubi W. H. Ziegler W. Vetter 《Journal of molecular medicine (Berlin, Germany)》1977,55(15):725-733
Summary Interrelations between age and plasma renin, aldosterone and cortisol levels, urinary catecholamines, plasma and blood volumes, exchangeable body sodium and blood pressure were studied in 28 young (19 to 29 years), 16 middle-aged (32 to 58 years) and 15 elderly (60 to 74 years) healthy subjects. Supine and upright plasma renin and supine aldosterone levels decreased while urinary noradrenaline excretion rate increased progressively with aging (r0.34;p<0.05), with significant differences in mean values between young and elderly subjects (p<0.02). There was also an age-related decrease in upright plasma aldosterone concentration, although this was not statistically significant. Furthermore, mean plasma cortisol concentrations increased in response to upright posture in elderly (+50%;p<0.02), but not in young (–10%) or middle-aged (–8%) subjects. Blood pressure correlated with age (r=0.35;p<0.05) or noradrenaline excretion rate (r=0.34) in the entire study population and with blood volume in the elderly (r=0.68), but not in the young or middle-aged study groups. There were no significant age-related differences in the body sodium/volume state, basal plasma cortisol levels or urinary adrenaline excretion rate, and plasma renin or aldosterone levels did not correlate with these parameters or with blood pressure. It is concluded that the influence of age on plasma renin or aldosterone levels, plasma cortisol responsiveness to upright posture, and urinary noradrenaline excretion should be taken into consideration, whenever these factors have to be interpreted in patients with arterial hypertension or other clinical disorders. Furthermore, these data are consistent with the possibility that in normal man increases in supine blood pressure with aging may be related at least partly to concomitant changes in free peripheral noradrenaline.This investigation was supported by the Swiss National Science Foundation 相似文献
6.
The mouse Pax21Neu
mutation is identical to a human PAX2
mutation in a family with renal-coloboma syndrome and results
in developmental defects of the brain, ear, eye, and kidney 下载免费PDF全文
Jack Favor Rodica Sandulache Angelika Neuhuser-Klaus Walter Pretsch Bimal Chatterjee Elfriede Senft Wolfgang Wurst Vronique Blanquet Patricia Grimes Ralf Sprle Klaus Schughart 《Proceedings of the National Academy of Sciences of the United States of America》1996,93(24):13870-13875
We describe a new mouse frameshift mutation (Pax21Neu) with a 1-bp insertion in the Pax2 gene. This mutation is identical to a previously described mutation in a human family with renal-coloboma syndrome [Sanyanusin, P., McNoe, L. A., Sullivan, M. J., Weaver, R. G. & Eccles, M. R. (1995) Hum. Mol. Genet. 4, 2183–2184]. Heterozygous mutant mice exhibit defects in the kidney, the optic nerve, and retinal layer of the eye, and in homozygous mutant embryos, development of the optic nerve, metanephric kidney, and ventral regions of the inner ear is severely affected. In addition, we observe a deletion of the cerebellum and the posterior mesencephalon in homozygous mutant embryos demonstrating that, in contrast to mutations in Pax5, which is also expressed early in the mid-hindbrain region, loss of Pax2 gene function alone results in the early loss of the mid-hindbrain region. The mid-hindbrain phenotype is similar to Wnt1 and En1 mutant phenotypes, suggesting the conservation of gene regulatory networks between vertebrates and Drosophila. 相似文献
7.
8.
Neumann M Wirtz M Bollschweiler E Mercer SW Warm M Wolf J Pfaff H 《Patient education and counseling》2007,69(1-3):63-75
OBJECTIVE: The aim of the present cross-sectional study was to explore patient- and physician-specific determinants of physician empathy (PE) and to analyse the influence of PE on patient-reported long-term outcomes in German cancer patients. METHODS: A postal survey was administered to 710 cancer patients, who had been inpatients at the University Hospital Cologne (response rate 49.5%). PE was measured with the German translation of the consultation and relational empathy (CARE) measure, and patient-reported long-term outcomes were assessed using the major (ICD-10) depression inventory (MDI) and the EORTC quality of life (Qol) questionnaire QLQ-C30. Hypotheses were tested by structural equation modelling. RESULTS: PE had (a) a moderate indirect effect on "depression" and a smaller indirect effect on "socio-emotional-cognitive Qol" by affecting "desire for more information from the physician regarding findings and treatment options" and (b) a moderate indirect effect on "socio-emotional-cognitive Qol" and a smaller effect on "depression" via "desire for more information about health promotion". The determinant with the greatest importance was "patient-perceived general busyness of hospital staff": it had a strong negative influence on PE, indirectly influencing "desire for more information from the physician regarding findings and treatment options" and also patients' "depression". CONCLUSION: PE seems to be an important pre-requisite for information giving by physicians and through this pathway having a preventive effect on depression and improving Qol. Conversely, physicians' stress negatively influences these relationships. PRACTICE IMPLICATIONS: The research findings suggest that reducing physicians' stress at the organizational and individual may be required to enhance patient-physician communication. Empathy, as an outcome-relevant professional competence needs to be assessed and developed more intensively in medical students and physicians. 相似文献
9.
10.
Ricardo A. Spampinato Cosima Jahnke Ingo Paetsch Sebastian Hilbert Franziska Busch Valerie Schloma Yaroslava Dmitrieva Fernanda Bonamigo Thome Susanne Löbe Elfriede Strotdrees Gerhard Hindricks Friedrich-Wilhelm Mohr Michael A. Borger 《Journal of the American Society of Echocardiography》2018,31(1):42-51