全文获取类型
收费全文 | 9106篇 |
免费 | 415篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 177篇 |
儿科学 | 178篇 |
妇产科学 | 53篇 |
基础医学 | 1098篇 |
口腔科学 | 232篇 |
临床医学 | 564篇 |
内科学 | 2041篇 |
皮肤病学 | 84篇 |
神经病学 | 728篇 |
特种医学 | 333篇 |
外科学 | 1976篇 |
综合类 | 50篇 |
一般理论 | 1篇 |
预防医学 | 313篇 |
眼科学 | 74篇 |
药学 | 459篇 |
中国医学 | 14篇 |
肿瘤学 | 1221篇 |
出版年
2023年 | 52篇 |
2022年 | 115篇 |
2021年 | 199篇 |
2020年 | 115篇 |
2019年 | 141篇 |
2018年 | 215篇 |
2017年 | 150篇 |
2016年 | 222篇 |
2015年 | 221篇 |
2014年 | 298篇 |
2013年 | 322篇 |
2012年 | 572篇 |
2011年 | 621篇 |
2010年 | 373篇 |
2009年 | 346篇 |
2008年 | 505篇 |
2007年 | 559篇 |
2006年 | 584篇 |
2005年 | 585篇 |
2004年 | 537篇 |
2003年 | 484篇 |
2002年 | 448篇 |
2001年 | 158篇 |
2000年 | 143篇 |
1999年 | 172篇 |
1998年 | 137篇 |
1997年 | 91篇 |
1996年 | 90篇 |
1995年 | 67篇 |
1994年 | 64篇 |
1993年 | 60篇 |
1992年 | 88篇 |
1991年 | 95篇 |
1990年 | 95篇 |
1989年 | 95篇 |
1988年 | 89篇 |
1987年 | 57篇 |
1986年 | 54篇 |
1985年 | 49篇 |
1984年 | 38篇 |
1983年 | 39篇 |
1982年 | 28篇 |
1981年 | 15篇 |
1980年 | 33篇 |
1979年 | 34篇 |
1978年 | 23篇 |
1977年 | 21篇 |
1976年 | 10篇 |
1974年 | 10篇 |
1972年 | 11篇 |
排序方式: 共有9596条查询结果,搜索用时 15 毫秒
1.
2.
A Kubota A Okada K Imura H Kawahara R Nezu S Kamata Y Takagi 《Journal of pediatric surgery》1990,25(6):618-621
The effect of metronidazole (MNZ) on hepatic dysfunction associated with total parenteral nutrition (TPN) in neonates was investigated. Neonates receiving TPN for more than 2 weeks were divided into three groups. In group 1, TPN was given alone, in group 2, 25 mg/kg/d of MNZ was administered intravenously for the first 2 weeks of TPN, and in group 3, 50 mg/kg/d of MNZ was given for the first 3 weeks of TPN. Several parameters of liver function tests (LFTs) during the first 4 weeks of TPN were compared among these three groups. There was no significant difference of these parameters between group 1 and group 2. Although there was no significant difference of alkaline phosphatase, gamma-glutamyl transpeptidase, direct bilirubin, and total bile acid between groups 1 and 3, transaminase (glutamic oxaloacetic, glutamic pyruvic) of group 3 remained significantly lower than those of group 1. In conclusion, the administration of MNZ 50 mg/kg/d for 3 weeks, at least, prevented the elevation of transaminase during TPN in neonates, suggesting the possible involvement of intestinal anaerobic flora in the pathogenesis of TPN-associated liver dysfunction. 相似文献
3.
We report a rare case of advanced renal cell carcinoma in apatient who showed complete resolution of metastases to thelung and bones after nephrectomy, partial jejunectomy and subsequentalpha-interferon therapy. The patient was a 54-year-old manwhose right lung and left femur metastases were detected beforenephrectomy. In the seventh week after nephrectomy, a partialjejunectomy was carried out because of the obstructive ileuscaused by intraluminal multiple metastases of the jejunum. Apathological fracture of the metastasized right humerus occurredsubsequently. After four months of intramuscular alpha-interferonadministration (3x106 units/day), however, x-rays revealed thecomplete disappearance of the metastatic lung shadow and a solidunion of the humerus, and there were no tumor cells in the femurspecimen resected at the subsequent reconstruction surgery ofthe left leg. Seven years have passed from onset, and the patientis still alive and disease free. 相似文献
4.
Eiji Takeuchi Yuji Nimura Shin-ichi Mizuno Hideaki Suzuki Shinsuke Iyomasa Masaki Terasaki Hiroshi Kuriki Keiko Tamiya-Koizumi Shonen Yoshida 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(3):254-262
Hepatocyte regeneration has been widely investigated, with the mitotic index and the incorporation of [3H]thymidine being used as regeneration markers. We focused on the induction of DNA replication enzymes, particularly DNA polymerases
(pol) α, δ, and ε. Using rat models, we have shown that the activity of pol α in crude liver extract well represents the regenerating
capacity of hepatocytes. Using pol α as an indicator, we analyzed liver regeneration in rat models under various conditions:
obstructive jaundice, external or internal biliary drainage, and the obstruction of portal vein branches. It has been revealed
that the ligation of the common bile duct alone induces a certain amount of hepatocyte proliferation. It was striking that
external biliary drainage suppressed regeneration capacity in cholestatic rat liver after partial hepatectomy. The strong
regeneration in nonligated lobes induced by portal branch ligation was similar to the liver regeneration seen after partial
hepatectomy with respect to the induction of DNA polymerases. Taken together, the aspects of DNA replication, particularly
the induction of DNA polymerases, may contribute to shedding new light on the regeneration of human liver.
This work was supported in part by a Grant-in-Aid for General Scientific Research and for Cancer Research from the Ministry
of Education, Science and Culture, Japan, and by grants from the Uehara Memorial Foundation 相似文献
5.
Hideya Ohnishi Kazuyoshi Nishihara Keiyoshi Tamae Shoshu Mitsuyama Ryuji Abe Satoshi Toyoshima Eiji Abe 《Surgery today》1996,26(11):929-932
Granular cell tumors (GCT) are rare neoplasms, and only 173 cases of benign GCT of the breast have been documented. We report herein the cases of two patients with this tumor and discuss the methods of diagnosis and treatment. The first patient was a 60-year-old woman who presented with a firm ill-defined mass in her left breast. Mammography showed a dense shadow with spicula and skin thickness, and ultrasonography revealed a hypoechoic mass with an irregular border. Radical mastectomy was performed under the wrong preoperative diagnosis of breast cancer. The second patient was a 31-year-old woman who presented with an elastic-hard mass in her left breast. Mammography showed a well-demarcated dense mass, and ultrasonography revealed a well-defined hypoechoic mass with a large depth-width ratio. Fine-needle aspiration cytology (FNAC) showed a large number of histiocytic cells with abundant granular cytoplasm. An excisional biopsy was performed, and histological examination confirmed a diagnosis of GCT. GCT is benign, but often misdiagnosed as breast cancer both clinically and radiologically. Therefore, histological examination is essential for making a correct diagnosis, while FNAC is also useful. Local resection is still the treatment of choice, and surgeons should do their utmost to avoid performing needless radical mastectomy. 相似文献
6.
Kazuta Fukumori Yoichi Yano Koutaro Kuwaki Shuji Sumie Eiji Ando Masatoshi Tanaka Michio Sata 《Nihon Shokakibyo Gakkai zasshi》2007,104(8):1225-1230
A 64-year-old man was admitted for further examinations of a liver tumor. The patient was diagnosed as chronic hepatitis C complicated with advanced hepatocelluar carcinoma (HCC) with left portal vein tumor thrombosis. As he refused surgical treatment, hepatic arterial infusion chemotherapy (HAIC) using cisplatin and 5-fluorouracil was performed initially. Administration of ursodesoxycholic acid (UDCA) was also started. Following HAIC, microwave coagulation therapy for residual tumor was added. Consequently, viable lesions of HCC disappeared completely. At present, after more than 8 years, neither signs of tumor recurrence, nor elevation of hepatic enzymes has been observed. Although the precise reason for long survival of this patient is not known, we speculate that suppression of levels of hepatic enzymes, as well as HAIC for subclinical intrahepatic metastasis, contributed to the good outcome. Therapeutic strategy for hepatic inflammation seems to be important for long-term prevention of hepatocarcinogenesis. 相似文献
7.
Yasuaki Saijo Eiji Yoshioka Tomonori Fukui Mariko Kawaharada Reiko Kishi 《Hypertension research》2006,29(8):589-596
The aim of this study was to investigate whether the metabolic syndrome (MS) was associated with an elevated level of C-reactive protein (CRP) and increased arterial stiffness, and to clarify whether combined MS and CRP data had a stronger relation to arterial stiffness than did MS data alone. Brachial-ankle pulse wave velocity (baPWV), CRP, and conventional risk factors were evaluated in 3,412 men and 854 women. Adjusted mean values of baPWV in men with 0, 1, 2, and > or = 3 components were 1,309, 1,372, 1,422, and 1,462 cm/s, respectively (p for trend <0.001). Adjusted mean values of baPWV in women with 0, 1, 2, and > or =3 components were 1,212, 1,292, 1,357, and 1,391 cm/s, respectively (p for trend <0.001). Adjusted geometric mean concentrations of CRP in men with 0, 1, 2, and > or = 3 components were 0.036, 0.049, 0.059, and 0.076 mg/dI, respectively (p for trend <0.001). Adjusted geometric mean concentrations of CRP in women with 0, 1, 2, and > or = 3 components were 0.023, 0.030, 0.057, and 0.077 mg/dI, respectively (p for trend <0.001). In analyses of adjusted mean values of baPWV according to the number of MS components and according to CRP levels within or without top quartile levels, the p value for the trend was significant (<0.001) in both men and women but, in post hoc analyses, comparing high and low CRP levels in each MS component-number group, no significant difference was found. These results suggest that, for prediction of increased arterial stiffness, combining MS and CRP data has little additive effect compared to the use of MS data alone. 相似文献
8.
Kenji Tsukada Shigeru Kobayashi Tatsuya Gotoh Naoki Asakage Masayuki Sekine Morio Sasaki Eiji Miyazaki Takahisa Suzuki Toshio Yamada Shu Hirai Shigetaka Yamazaki 《Digestive endoscopy》2006,18(1):55-58
A case of early gastric carcinoma accompanied by Dieulafoy ulcer is presented. The patient, a 26‐year‐old female, visited our emergency room with chief complaints of massive hematemesis and tarry stool. The initial endoscopic examination revealed a superficial depressed lesion with a faded color accompanied by a tiny ulcer with converging folds at the anterior wall of the middle gastric body. Although no active bleeding vessel was found at that time, the patient was admitted to our hospital for further check‐ups and treatment. On the 6th hospital day, she developed massive hematemesis resulting in shock. Urgent endoscopy, this time, disclosed an exposed bleeding vessel at the small ulcer floor previously mentioned, and endoscopic hemostasis was achieved. Since, however, a biopsy at initial examination from the surrounding depressed area proved carcinoma, a partial distal gastrectomy was subsequently carried out. Histological examination of the resected specimen confirmed the diagnosis of carcinoma limited to the mucosa and submucosa along with findings consistent with Dieulafoy ulcer. This is a rare case of combination of early cancer and Dieulafoy ulcer particularly in such a young patient. A review of the literature is also presented. 相似文献
9.
K Imura A Okada Y Fukui H Kawahara M Yagi A Kubota S Kanaya S Kamata Y Nagata 《JPEN. Journal of parenteral and enteral nutrition》1988,12(5):496-504
In 97 neonates receiving total parenteral nutrition in the postoperative period, clinical assessment was made for a newly devised amino acid solution (PF-I-III) from the standpoint of plasma amino acid profile and nutritional effect. These amino acid solutions prepared are characterized by the high concentration of branched-chain amino acids up to 40%, increased arginine and decreased glycine, phenylalanine and methionine as compared with commercially available solutions. In the PF group, each amino acid was kept within the range of standard value. Correlation between plasma amino acid profiles and the dose of each amino acid administered was obtained, from which minimum, standard, and maximum doses for each amino acid was determined. Based on these values, we proposed new formula for neonates which elicits no abnormal plasma amino acid pattern even when amino acids are administered at the dosage level of 1.5-2.5 g/kg/day. 相似文献
10.
Yasuo Miyoshi Seigoh Mizumoto MD Hideo Akashi Eiji Kurokawa Hideyuki Mishima Keisuke Iihara Kohji Takami Masayuki Ohue Yukitoshi Aoki 《Surgery today》1990,20(6):711-714
A rare case of jejunal carcinoma coexisting with adenoma, situated 120 cm distal to the ligament of Treitz in a 53 year old
male, is reported herein. We also review cases of adenoma and carcinoma in the jejunum and ileum from the Japanese literature,
and discuss the histogenesis of carcinoma of the jejunum and ileum. 相似文献