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1.
KENICHI TATSUMI TSUNEATSU MORI ETSUKO MORI HIDEHARU KANZAKI TAKAHIDE MORI 《American journal of reproductive immunology (New York, N.Y. : 1989)》1987,13(3):87-92
ABSTRACT: The culture supernatant of the TTK-1 cell line, established from human decidual tissue, was found to contain a factor that strongly suppressed the mixed lymphocyte reaction (MLR). The mechanism of the MLR-suppressive activity as well as the biochemical characterization of this factor was analyzed. The TTK-1 supernatant suppressed the MLR much more strongly than the culture supernatants of the three other malignant cell lines examined. The molecular weight of this factor was estimated to be between 43 kilodaltons (kd) and 67 kd by gel filtration chromatography. The TTK-1 supernatant also suppressed the proliferation of the interleukin 2 (IL-2)-dependent T cell lines, but did not suppress that of the IL-2-independent T cell lines, suggesting that the TTK-1 supernatant inhibited the action of IL-2 and subsequently suppressed the MLR. The fact that the TTK-1 cell line originated from human decidual tissue might imply the important role of this factor in immunological fetomaternal balance. 相似文献
2.
YOSHITANE KOJIMA YOUKO IKEDA ETSUKO KUMATA JOJI MARUO AKIHIRO OKAMOTO KEN HIROTSU KOZO SHIBATA AKIO OHSUKA 《Chemical biology & drug design》1991,37(6):468-475
The solution conformations of novel dipeptides, methyl (2S, 3′S)-3-methyl-2-(2′-oxo-3′-isopropyl-1′-piperazinyl)-butanoate (EVV-OCH3), methyl (2S, 3′S)-3-phenyl-2-(2′-oxo-3′-benzyl-1′-piperazinyl) propionate (EFF-OCH3), and their derivatives (Boc-Gly-EW-OH, Boc-Gly-EVV-Gly-OH, and Boc-Gly-EFF-OH), were studied by ‘H NMR measurements and molecular mechanics calculations (1). The molecular structures of Boc-Gly-EVV-OH, Boc-Gly-EFF-OH, and the hydrochloride of EVV-OCH3 were determined by X-ray analyses. The conformations of the piperazinone rings and the side chains of these oligopeptides were clarified. 相似文献
3.
KOJI KUMAGAI M.D. Ph.D. SHIGETO NAITO M.D. Ph.D. KOKI NAKAMURA M.D. TATSUYA HAYASHI M.D. RIE FUKAZAWA M.D. CHIZURU SATO M.D. NAOKI TAKEMURA M.D. YUKO MIKI M.D. Ph.D. ETSUKO FUKE M.D. YASUAKI TANAKA M.D. YASUHIKO HORI M.D. KOJI GOTO M.D. JOTARO IWAMOTO M.D. KAZUTAKA AONUMA M.D. Ph.D. SHIGERU OSHIMA M.D. Ph.D. KOICHI TANIGUCHI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2010,21(5):494-500
Dormant Pulmonary Veins from the Carina Region . Introduction: Elimination of transient pulmonary vein recurrences (dormant PVs) induced by an ATP injection and ablation at the PV carina region is an effective strategy for atrial fibrillation (AF) ablation. The relationship between dormant PVs and the PV carina region has not been evaluated. Methods: A total of 212 consecutive symptomatic AF patients underwent circumferential PV electrical isolation (CPVEI) with a double lasso technique. They were divided into 2 groups in a retrospective review; Group 1: those given an ATP injection during an intravenous isoproterenol infusion after the CPVEI (n = 106), and Group 2: those in which it was not given after the CPVEI (n = 106). Radiofrequency energy was applied at the earliest dormant PV activation site identified using a Lasso catheter on the CPVEI line and then PV carina region if it was ineffective. Results: After a successful PVEI, 54 patients (51%) in Group 1 had PV reconnections during an ATP injection. Acute PVEI sites were observed on the carina region within the CPVEI line in the right PVs (16%) and left PVs (10%). Dormant PVs were reisolated at the carina region in the right PVs (23%) and left PVs (26%). The distribution of the dormant PV sites, except for the RIPV, significantly differed from that of the acute PVEI sites (P < 0.05). Further, AF recurred significantly in the Group 2 patients as compared to those in Group 1 during 16 ± 6.1 months of follow‐up (P < 0.05). Conclusion: PV carina region origins may partly be responsible for an acute PVEI and potential recurrences. (J Cardiovasc Electrophysiol, Vol. 21, pp. 494‐500, May 2010) 相似文献
4.
SANADA ISAO; YAMAMOTO SEIKO; OGATA MISA; KAWAKITA MAKOTO; KAWANO FUMIO; FUJIWARA HIROKAZU; TANAKA RYUJI; KUMAGAI ETSUKO; TAKATSUKI KIYOSHI 《Japanese journal of clinical oncology》1985,15(3):553-558
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferativedisorder, differentiated from chronic myelogenous leukemia byseveral features. A case of CNL which was found by long-termculture to involve the Philadelphia chromosome is reported. 相似文献
5.
HIDEKI NISHIO TATSUYA INUI YUJI NISHIUCHI CLEANE L.C. DE MEDEIROS EDWARD G. ROWAN ALAN L. HARVEY ETSUKO KATOH TOSHIMASA YAMAZAKI TERUTOSHI KIMURA SHUMPEI SAKAKIBARA 《Chemical biology & drug design》1998,51(5):355-364
Dendrotoxin I (DTX-I) is a 60-residue peptide from the venom of the black mamba snake Dendroaspis polylepis, which binds to neuronal K+ channels. The structure reported previously for DTX-I was synthesized for the first time by a solution procedure. The synthetic product was confirmed to have the correct primary and disulfide structure determined by peptide mapping, sequence analysis and mass measurements. Comparison of synthetic DTX-I with the natural one by high-performance liquid chromatography and capillary zone electrophoresis, as well as by sequence analysis, revealed that the Asn residue at position 12 in the synthetic peptide was Asp in the natural product. Synthesis of DTX-I with Asp at position 12 gave a peptide identical with the natural product in all aspects. NMR analysis of synthetic [Asn12]. - and [Asp12]. -DTX-I also supported our findings that the Asn residue at position 12 in the DTX-I molecule should be revised as Asp. [Asn12]. - and [Asp12]. -DTX-I had very similar binding affinities when tested against radiolabeled dendrotoxin binding to rat brain synaptosomal membranes. © Munksgaard 1998. 相似文献
6.
KIYOSHI TAKEYAMA JUN TAMAOKI ATSUSHI CHIYOTANI ETSUKO TAGAYA KIMIO KONNO 《The Journal of pharmacy and pharmacology》1993,45(8):756-758
Abstract— We have studied ciliary beat frequency (CBF) of rabbit cultured tracheal epithelium by a photoelectric method in-vitro. Addition of erythromycin and roxithromycin increased CBF in a dose-dependent fashion, whereas clarithromycin was without effect. The rank order potency of macrolide was roxithromycin > erythromycin » clarithromycin. The roxithromycin-induced increase in CBF was not altered by propranolol, AA-861, or verapamil, but partially attenuated by indomethacin. Roxithromycin increased intracellular cAMP concentrations. These results suggest that certain macrolides can stimulate airway ciliary motility probably via prostaglandin- and cAMP-dependent regulatory pathways, which may affect mucociliary transport function in the respiratory tract. 相似文献
7.
YUKIKATSU NAKADA KYOKO KAMIYA ETSUKO TAKAESU SATOSHI OHSHIRO TOMIKO HOKAMA SATOSHI NAKASONE KIYOTAKE HIRAYAMA 《Pediatrics international》1996,38(3):229-232
The prevalence rate of severely mentally and physically disabled children (SDC) aged 6–15 years in Okinawa prefecture on 1 May 1989 was 0.74/1000 (143/192 038) according to Oshima's classification, compared with 0.89/1000 (170/192 038) according to the Ministry of Education's classification with minor modifications. The number of children in region classes 1, 2, 3 and 4 of Oshima's classification for SDC were 100, 34, 6 and 3, respectively. The difference (n = 27) between the total numbers of SDC according to the two classifications was mainly because of 21 children categorized as ‘walking with support’ who were included as SDC according to the Ministry of Education's classification but not as SDC according to Oshima's classification. Only region class 1 of Oshima's classification corresponded with region class 25 of the Ministry of Education's classification. The results of the present study indicate that the differences between the two definitions of SDC affect the reported prevalence rates of SDC. Therefore, changing patterns in the prevalence of SDC should be assessed by serial surveys using the same method in each district. 相似文献
8.
The role of podocytes in proteinuria 总被引:1,自引:0,他引:1
KATSUHIKO ASANUMA ETSUKO YANAGIDA-ASANUMA MIYUKI TAKAGI FUMIKO KODAMA YASUHIKO TOMINO 《Nephrology (Carlton, Vic.)》2007,12(S3):S15-S20
SUMMARY: Glomerular visceral epithelial cells, also known as podocytes, are highly specialized epithelial cells that cover the outer layer of the glomerular basement membrane. Podocytes consist of cell bodies, major processes and foot processes (FP) of neighbouring cells, with the filtration slits bridged by the slit membrane between them. The function of podocytes is largely based on their specialized cell architecture and functions such as stabilization of glomerular capillaries and participation in the barrier function of the glomerular filter. Therefore, they form the final barrier to protein loss, which explains why podocyte injury is typically associated with marked proteinuria. Under pathological conditions, podocytes exhibit various changes. Among these changes, FP effacement represents the most characteristic change in cell shape of podocytes. FP effacement is dependent on disruption of the actin cytoskeletal network in the podocytes, The mechanisms of organization and re-organization of actin in the FP of podocytes are discussed in this review. 相似文献
9.
ETSUKO ISONO KATSUMI YAMAUCHI IKUKO HARUTA YUMIKO KAMOGAWA NAOAKI HAYASHI 《Journal of gastroenterology and hepatology》1995,10(1):24-29
Abstract To study the mechanism of the effects of α-interferon (α-IFN) on chronic hepatitis B, we examined its effect on hepatitis B virus (HBV)-specific cytotoxic T cells (CTL). Using two different HBV-DNA transfected human myeloma cell lines, one expressing hepatitis B core antigen (HBcAg; C4) and the other expressing hepatitis B surface antigen (HBsAg; S6) as targets in cytotoxic tests in vitro , peripheral blood mononuclear cells obtained from chronic hepatitis B patients who were treated with α-IFN were examined for their cytotoxic activity against these transfectants. During the treatment with α-IFN, in association with a decline of serum alanine amino transferase levels, CTL activities were significantly reduced. An inhibition study in vitro revealed that α-IFN did not directly inhibit these CTL activities, indicating that α-IFN may inhibit the induction of CTL, and thereby may be related to the reduction of hepatocyte injury. 相似文献
10.
SHINICHI KAWAI KASUMI NAGAI SHINICHI NISHIDA KATSUFUMI SAKYO ETSUKO MURAI YUTAKA MIZUSHIMA 《The Journal of pharmacy and pharmacology》1997,49(2):213-215
The purpose of this study was to determine whether low-dose methotrexate pulse therapy, which had recently become important in the treatment of rheumatoid arthritis, was effective for controlling the progression of articular destruction in rats with adjuvant arthritis. Intraperitoneal methotrexate at a dose of 0.05 or 0.1 mg kg?1 twice weekly inhibited inflammation in rats with adjuvant arthritis, as shown by reduction of the hind-paw volume. Methotrexate also inhibited articular destruction, as shown by X-ray findings. Although the mechanisms by which low-dose pulse methotrexate acts on rat adjuvant arthritis are still unclear, our results imply that it might effectively slow the progression of articular destruction in rheumatoid arthritis in man. In addition, assessment of articular destruction in this animal model might be useful when evaluating new treatments for rheumatoid arthritis. 相似文献