全文获取类型
收费全文 | 1265328篇 |
免费 | 94902篇 |
国内免费 | 1578篇 |
专业分类
耳鼻咽喉 | 16318篇 |
儿科学 | 41040篇 |
妇产科学 | 34979篇 |
基础医学 | 189577篇 |
口腔科学 | 34749篇 |
临床医学 | 117860篇 |
内科学 | 248106篇 |
皮肤病学 | 27290篇 |
神经病学 | 102075篇 |
特种医学 | 46786篇 |
外国民族医学 | 265篇 |
外科学 | 178800篇 |
综合类 | 25772篇 |
现状与发展 | 3篇 |
一般理论 | 568篇 |
预防医学 | 104879篇 |
眼科学 | 28051篇 |
药学 | 92639篇 |
7篇 | |
中国医学 | 2022篇 |
肿瘤学 | 70022篇 |
出版年
2018年 | 13552篇 |
2017年 | 10417篇 |
2016年 | 11340篇 |
2015年 | 13102篇 |
2014年 | 18028篇 |
2013年 | 27528篇 |
2012年 | 37622篇 |
2011年 | 40026篇 |
2010年 | 23084篇 |
2009年 | 22287篇 |
2008年 | 37816篇 |
2007年 | 40444篇 |
2006年 | 40023篇 |
2005年 | 39177篇 |
2004年 | 37611篇 |
2003年 | 36009篇 |
2002年 | 34924篇 |
2001年 | 56081篇 |
2000年 | 57084篇 |
1999年 | 48141篇 |
1998年 | 13410篇 |
1997年 | 12239篇 |
1996年 | 12660篇 |
1995年 | 11929篇 |
1994年 | 11116篇 |
1993年 | 10404篇 |
1992年 | 38239篇 |
1991年 | 37712篇 |
1990年 | 36476篇 |
1989年 | 35279篇 |
1988年 | 32716篇 |
1987年 | 32050篇 |
1986年 | 30548篇 |
1985年 | 28816篇 |
1984年 | 21976篇 |
1983年 | 19227篇 |
1982年 | 11386篇 |
1981年 | 10338篇 |
1979年 | 20973篇 |
1978年 | 15410篇 |
1977年 | 12804篇 |
1976年 | 11862篇 |
1975年 | 12821篇 |
1974年 | 15613篇 |
1973年 | 15372篇 |
1972年 | 14518篇 |
1971年 | 13561篇 |
1970年 | 12794篇 |
1969年 | 12080篇 |
1968年 | 11237篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
Simeprevir added to peginterferon and ribavirin lessens time with fatigue,depressive symptoms and functional limitations in patients with chronic hepatitis C compared with peginterferon and ribavirin: results from 1161 patients in the QUEST‐1, QUEST‐2 and PROMISE studies 下载免费PDF全文
J. Scott L. Gilles M. Fu E. Brohan C. Panter R. Arbuckle W. Jessner M. Beumont 《Journal of viral hepatitis》2015,22(8):639-650
The value of adding simeprevir (SMV) vs placebo (PBO) to peginterferon and ribavirin (PR) for treatment of chronic hepatitis C virus infection was examined using patient‐reported outcomes (PROs); further, concordance of PROs with virology endpoints and adverse events (AEs) was explored. Patients (n = 768 SMV/PR, n = 393 PBO/PR) rated fatigue (FSS), depressive symptoms (CES‐D) and functional impairment (WPAI: Hepatitis C Productivity, Daily Activity and Absenteeism) at baseline and throughout treatment in three randomised, double‐blind trials comparing the addition of SMV or PBO during initial 12 weeks of PR. PR was administered for 48 weeks (PBO group) and 24/48 weeks (SMV group) using a response‐guided therapy (RGT) approach. Mean PRO scores (except Absenteeism) worsened from baseline to Week 4 to the same extent in both groups but reverted after Week 24 for SMV/PR and only after Week 48 for PBO/PR. Accordingly, there was a significantly lower area under the curve (baseline–Week 60, AUC60) and fewer weeks with clinically important worsening of scores in the SMV/PR group at any time point. Incidences of patients with fatigue and anaemia AEs were similar in both groups, but FSS scores showed that clinically important increases in fatigue lasted a mean of 6.9 weeks longer with PBO/PR (P < 0.001). PRO score subgroup analysis indicated better outcomes for patients who met the criteria for RGT or achieved sustained virological response 12 weeks post‐treatment (SVR12); differences in mean PRO scores associated with fibrosis level were only observed with PBO/PR. Greater efficacy of SMV/PR enabled reduced treatment duration and reduced time with PR‐related AEs without adding to AE severity. 相似文献
6.
Provocation of Atrial Fibrillation Triggers During Ablation: Does the Use of General Anesthesia Affect Inducibility? 下载免费PDF全文
7.
Marta Rozanski Valentin Neuhaus Emily Thornton Stéphanie J. E. Becker James P. Rathmell David Ring 《Journal of hand and microsurgery》2015,7(1):30-35
This study used the National Survey of Ambulatory Surgery (NSAS) database to measure the incidence of and risk factors for symptoms in the ambulatory surgery center and problems within 24 h after isolated carpal tunnel release (CTR). The NSAS contained records on 400,000 adult patients with carpal tunnel syndrome who were treated with CTR in 2006, based on ICD-9 codes. The type of anesthesia used and factors associated with symptoms and problems were sought in bivariate and multivariable statistical analyses. The mean duration of the procedure was 16 ± 8.8 min. Only 5 % were performed under local anesthesia without sedation, 45 % with IV sedation, 28 % regional anesthesia, and 19 % general anesthesia. Symptoms in the ambulatory surgery center or a problem within 24 h after discharge were recorded in 10 % of patients, all of them minor and transient, including difficulties with pain and its treatment. The strongest risk factors were male sex, age of 45 years and older, and participation of an anesthesiologist. Local anesthesia and regional anesthesia were associated with more perioperative symptoms and postoperative problems. Most CTR are performed with some sedation in the United States. CTR is a safe procedure: one in 10 patients will experience a minor issue in the perioperative or immediate postoperative period. 相似文献
8.
Michael E Egger Joanna M Ohlendorf Charles R Scoggins Kelly M McMasters Robert C G Martin II 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2015,17(9):839-845
BackgroundThe aim of this paper is to assess the current state of quality and outcomes measures being reported for hepatic resections in the recent literature.MethodsMedline and PubMed databases were searched for English language articles published between 1 January 2002 and 30 April 2013. Two examiners reviewed each article and relevant citations for appropriateness of inclusion, which excluded papers of liver donor hepatic resections, repeat hepatectomies or meta-analyses. Data were extracted and summarized by two examiners for analysis.ResultsFifty-five studies were identified with suitable reporting to assess peri-operative mortality in hepatic resections. In only 35% (19/55) of the studies was the follow-up time explicitly stated, and in 47% (26/55) of studies peri-operative mortality was limited to in-hospital or 30 days. The time period in which complications were captured was not explicitly stated in 19 out of 28 studies. The remaining studies only captured complications within 30 days of the index operation (8/28). There was a paucity of quality literature addressing truly patient-centred outcomes.ConclusionQuality outcomes after a hepatic resection are inconsistently reported in the literature. Quality outcome studies for a hepatectomy should report mortality and morbidity at a minimum of 90 days after surgery. 相似文献
9.
10.