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Experimental infection of immunodeficient NIH-3 (N:NIH-bg-nu-xid) mice with Borrelia burgdorferi was found to result in multisystem histopathologic lesions. In addition to T-cell deficiency due to the nude mutation, these mice have an x-linked defect affecting the B-cell maturation and the beige mutation resulting in the absence of NK cells. NIH-3 mice were susceptible to progressive infection with B. burgdorferi resulting in pancarditis, synovitis, and skeletal interstitial myositis whereas controls remained normal. Cardiomyopathy was characterized by inflammatory mononuclear infiltration and fibrillar necrosis. Synovial hyperplasia and inflammation were seen in the tibiotarsal and ulna-carpal joints. Advanced myositis was observed in peripheral skeletal muscle. Gastrointestinal submucosa, heart, and skeletal muscle were heavily colonized with B. burgdorferi. This mouse is proposed as a model for Lyme borreliosis carditis, synovitis, and myositis. 相似文献
5.
R. I. Markowitz W. Frederick N. S. Rosenfield J. H. Seashore P. H. Duray 《Pediatric radiology》1987,17(4):269-272
We describe a case of a full-term infant with severe respiratory failure and pulmonary insufficiency caused by an anomaly
consisting of a single, unilobar lung arising from the trachea and situated in the middle mediastinum. Plain film, echocardiogram,
and surgical aspects will be described and correlated with the post mortem findings and embryologic considerations. We were
unable to find a similar case reported in the literature and conclude that this rare lesion represent an intermediate form
between total and unilateral pulmonary agenesis.
Presented at the Society for Pediatric Radiology, Washington D.C. 12 April 1986 相似文献
6.
Cholecystokinin-decreased food intake in rhesus monkeys 总被引:1,自引:0,他引:1
7.
Molecular profiling of clinical tissue specimens: feasibility and applications 总被引:7,自引:0,他引:7 下载免费PDF全文
Emmert-Buck MR Strausberg RL Krizman DB Bonaldo MF Bonner RF Bostwick DG Brown MR Buetow KH Chuaqui RF Cole KA Duray PH Englert CR Gillespie JW Greenhut S Grouse L Hillier LW Katz KS Klausner RD Kuznetzov V Lash AE Lennon G Linehan WM Liotta LA Marra MA Munson PJ Ornstein DK Prabhu VV Prange C Schuler GD Soares MB Tolstoshev CM Vocke CD Waterston RH 《The American journal of pathology》2000,156(4):1109-1115
8.
This study analyses the influence of female and male patient age and human
menopausal gonadotrophin (HMG) requirements on clinical pregnancy rates and
live birth rates with ovulation stimulation using HMG in combination with
intrauterine insemination (IUI). In this study, 363 consecutive HMG/IUI
treatment cycles in 184 patients carried out at a university fertility
centre were analysed in a retrospective fashion. The main outcomes measured
were clinical pregnancy rates and live birth rates. Increased female
partner age (> or = 35) and male partner age (> or = 40) were found
to negatively influence pregnancy rates with HMG/ IUI therapy. In addition,
this study demonstrated a critical threshold of HMG requirements beyond
which pregnancy did not occur. No pregnancies occurred in treatment cycles
requiring > 25 ampoules (1875 IU) of menotrophins to achieve follicular
maturity, irrespective of patient age. In conclusion, female partner age,
male partner age, and HMG requirements all significantly influence
pregnancy rates with HMG/IUI therapy.
相似文献
9.
Adrenergic mechanisms in cerebral circulation of the goat 总被引:1,自引:0,他引:1
10.
S M Chan P B Hoffer N Maric S S Zoghbi J M Kirkwood M S Ernstoff P H Duray B Gerich 《Journal of nuclear medicine》1987,28(9):1441-1446
We compared the biodistribution of two radiolabeled, whole, tumor selective monoclonal antibodies [( 111In]96.5, [111In]ZME-018) to 67Ga in nude mice bearing a human melanoma known to express p97 antigen. Localization of gallium was determined 48 hr following i.v. injection. Localization of the radiolabeled antibodies was determined at 3 days and 7 days following i.v. injection. All agents showed more or less similar absolute tumor uptake which varied between 22% and 36% of the injected dose per gram of tumor. Only the tumor uptake of [111In]96.5 antibody at 7 days was significantly lower than the 67Ga uptake at 48 hr. However, uptake in normal tissues was generally higher for both antibodies at 3 and 7 days than for 67Ga uptake at 48 hr. Therefore, the tumor-to-blood ratio for 67Ga was tenfold higher than that for either antibody, the tumor-to-muscle ratio was twofold higher. Bone was the only organ in which the tumor-to-organ ratio was consistently higher with radiolabeled antibody than with 67Ga. The tumor-to-liver and tumor-to-intestine ratios were comparable. Localization of the two tumor selective antibodies was greater than a nonspecific "control antibody" [( 111In]CEA) and change in specific activity from 0.17 mCi/mg to 3.3 mCi/mg did not influence localization. From these animal data it may be anticipated that tumor imaging with [111In]96.5 or [111In]ZME-018 will not be superior to imaging with 67Ga for detection of melanoma. 相似文献