医用胶根管充填材料的试验研究

目的探讨医用胶在根管治疗术中堵塞根管的密合程度及作用机制。方法应用显微镜、扫描电镜对医用胶根管充填材料和牙胶尖常规充填材料进行对比研究。结果医用胶根管充填材料在根管中质地均匀,根尖孔及根管壁充填密合。结论医用胶可以作为一种新型根管充填材料,应用于临床根管治疗术。     

Input of microenvironmental regulation on colorectal cancer: Role of the CCN family

Colorectal cancer(CRC)is a major health problem causing significant morbidity and mortality.Previous results from various studies indicate that CRC tumorigenicity encompasses tumor microenvironment,emphasizing the complex interacting network between cancer cells and nearby host cells,which triggers diverse signaling pathways to promote the growth and spread ofcancer cells.The CCN family proteins share a uniform modular structure,mediating a variety of physiological functions,including proliferation,apoptosis,migration,adhesion,differentiation,and survival.Furthermore,CCN proteins are also involved in CRC initiation and development.Many studies have shown that CCN members,such as CCN1,CCN2,CCN3,Wnt-induced secreted protein(WISP)-1,WISP-2,and WISP-3,are dysregulated in CRC,which implies potential diagnostic markers or therapeutic targets clinically.In this review,we summarize the research findings on the role of CCN family proteins in CRC initiation,development,and progression,highlighting their potential for diagnosis,prognosis,and therapeutic application.     

影响器械进入上颌磨牙近颊根第二根管的因素

目的:分析影响器械进入上颌磨牙近颊根第二根管的因素和评价根管显微镜定位离体上颌磨牙近颊根第二根管的能力。方法:①收集离体上颌第一、二磨牙共550颗;②在常规和根管显微镜辅助下分别探查近颊根管,记录近颊根第二根管检出率和影响器械进入该根管的因素。结果:①常规和根管显微镜条件下近颊根第二根管检出率在上颌第一磨牙分别为51.8%(112/216)和78.2%(169/216);第二磨牙分别为23.7%(79/334)和41.3%(138/334)。使用根管显微镜可明显提高近颊根第二根管的检出率,P<0.01;②影响器械进入近颊根第二根管的主要因素有近中壁牙本质悬突、牙本质碎屑和髓腔弥漫性钙化物或髓石等。结论:根管显微镜辅助下可有效去除阻碍器械进入近颊根第二根管的因素,提高其检出率。