Using cycloferon in complex therapy of patients with cutaneous vasculitis (clinical and immunological rationale)

The immunological status was assessed in a group of patients with superficial and profound cutaneous vasculitis diagnoses. It was established that, in both forms of vasculitis, the same type of immune reactions such as activation of cellular and humoral immunity links took place on the background of leucocytosis and lymphocytosis. The violation of T-helper/T-suppressor (Th/Ts) correlation was accompanied by intense stimulation of the helper lymphocyte subpopulation in both forms of vasculitis. In addition, some differences were observed in pathogenesis of the two forms of vasculitis, which were manifested by (i) a marked increase in the level of Ts cells in patients with superficial and a decrease in this level in patients with profound cutaneous vasculitis. In cases of a more serious profound form of vasculitis, it was found that a more intense stimulation of the humoral and fagocyte links of immune regulation took place. The inclusion of cycloferon into the complex therapy led to expressed immunomodulation effect, increase in the clinical therapeutic effect, reduction of the terms of hospitalization, and prolongation of the periods of disease remission.     

Characterization of secondary immune deficiency in patients with chronic glomerulonephritis

A study was made of the nature of secondary immuno-deficiency, peculiarities of disordered function of regulatory T-lymphocytes (helpers and suppressors), and their interrelationships in different clinical variants of chronic glomerulonephritis (CGN). Altogether 94 CGN patients were examined, of them 34 were with urinary syndrome and 60 with nephrotic syndrome. With relation to a clinical variant of disease the absolute amount of T-lymphocytes was significantly lowered, the amount and function of B-lymphocytes showed a tendency to an increase. Function of nonspecific Concanavalin A-induced T-suppressors using PHA as a mitogenic indicator (T-T-suppression) was insignificantly raised, and when lipopolysaccharide (T-B-suppression) was used it was considerably suppressed. T-lymphocyte helper activity in CGN patients was on an increase.     

The diagnosis and treatment of wounds to the lumbar area

An analysis of results of treatment of 228 patients with wounds of the lumbar region has shown that in 66.2% of cases they were not penetrating, in 33.8% they were penetrating. In 42 patients there were injuries of internal organs and of the vessels of the abdominal cavity and retroperitoneal space. The casualties must be examined under conditions of the emergency operating room and which in addition to thorough revision of the wound must include subsidiary methods of examination: USI, survey radiography of the thoracic and abdominal cavities and diagnostic survey laparoscopy, if necessary.