全文获取类型
收费全文 | 1523篇 |
免费 | 78篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 89篇 |
妇产科学 | 24篇 |
基础医学 | 137篇 |
口腔科学 | 40篇 |
临床医学 | 126篇 |
内科学 | 284篇 |
皮肤病学 | 16篇 |
神经病学 | 133篇 |
特种医学 | 121篇 |
外科学 | 281篇 |
综合类 | 64篇 |
一般理论 | 1篇 |
预防医学 | 85篇 |
眼科学 | 24篇 |
药学 | 103篇 |
中国医学 | 1篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 6篇 |
2022年 | 14篇 |
2021年 | 32篇 |
2020年 | 20篇 |
2019年 | 41篇 |
2018年 | 70篇 |
2017年 | 46篇 |
2016年 | 52篇 |
2015年 | 43篇 |
2014年 | 62篇 |
2013年 | 69篇 |
2012年 | 59篇 |
2011年 | 59篇 |
2010年 | 67篇 |
2009年 | 55篇 |
2008年 | 49篇 |
2007年 | 55篇 |
2006年 | 72篇 |
2005年 | 36篇 |
2004年 | 44篇 |
2003年 | 28篇 |
2002年 | 30篇 |
2001年 | 26篇 |
2000年 | 30篇 |
1999年 | 33篇 |
1998年 | 48篇 |
1997年 | 39篇 |
1996年 | 46篇 |
1995年 | 23篇 |
1994年 | 20篇 |
1993年 | 28篇 |
1992年 | 21篇 |
1991年 | 17篇 |
1990年 | 16篇 |
1989年 | 11篇 |
1988年 | 40篇 |
1987年 | 29篇 |
1986年 | 22篇 |
1985年 | 27篇 |
1984年 | 19篇 |
1983年 | 10篇 |
1982年 | 8篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1972年 | 11篇 |
1967年 | 5篇 |
排序方式: 共有1609条查询结果,搜索用时 15 毫秒
1.
Giorgio Gandaglia Guillaume Ploussard Massimo Valerio Agostino Mattei Cristian Fiori Nicola Fossati Armando Stabile Jean-Baptiste Beauval Bernard Malavaud Mathieu Roumiguié Daniele Robesti Paolo Dell’Oglio Marco Moschini Stefania Zamboni Arnas Rakauskas Francesco De Cobelli Francesco Porpiglia Francesco Montorsi Alberto Briganti 《European urology》2019,75(3):506-514
Background
Available models for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) might not be applicable to men diagnosed via magnetic resonance imaging (MRI)-targeted biopsies.Objective
To assess the accuracy of available tools to predict LNI and to develop a novel model for men diagnosed via MRI-targeted biopsies.Design, setting, and participants
A total of 497 patients diagnosed via MRI-targeted biopsies and treated with RP and extended pelvic lymph node dissection (ePLND) at five institutions were retrospectively identified.Outcome measurements and statistical analyses
Three available models predicting LNI were evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analyses. A nomogram predicting LNI was developed and internally validated.Results and limitations
Overall, 62 patients (12.5%) had LNI. The median number of nodes removed was 15. The AUC for the Briganti 2012, Briganti 2017, and MSKCC nomograms was 82%, 82%, and 81%, respectively, and their calibration characteristics were suboptimal. A model including PSA, clinical stage and maximum diameter of the index lesion on multiparametric MRI (mpMRI), grade group on targeted biopsy, and the presence of clinically significant PCa on concomitant systematic biopsy had an AUC of 86% and represented the basis for a coefficient-based nomogram. This tool exhibited a higher AUC and higher net benefit compared to available models developed using standard biopsies. Using a cutoff of 7%, 244 ePLNDs (57%) would be spared and a lower number of LNIs would be missed compared to available nomograms (1.6% vs 4.6% vs 4.5% vs 4.2% for the new nomogram vs Briganti 2012 vs Briganti 2017 vs MSKCC).Conclusions
Available models predicting LNI are characterized by suboptimal accuracy and clinical net benefit for patients diagnosed via MRI-targeted biopsies. A novel nomogram including mpMRI and MRI-targeted biopsy data should be used to identify candidates for ePLND in this setting.Patient summary
We developed the first nomogram to predict lymph node invasion (LNI) in prostate cancer patients diagnosed via magnetic resonance imaging-targeted biopsy undergoing radical prostatectomy. Adoption of this model to identify candidates for extended pelvic lymph node dissection could avoid up to 60% of these procedures at the cost of missing only 1.6% patients with LNI. 相似文献2.
Six patients who injured their wrists had radiographs documenting a dorsal, 5- to 10-mm oblong fragment of bone immediately proximal to the base of the fourth and/or fifth metacarpal bones. The fragment was seen on the pronation oblique and/or lateral projections, but not on the posteroanterior projection. The radiographic appearance of the fragment was remarkably similar in all cases. In the one patient in which it was performed, pluridirectional tomography demonstrated that the fragment originated from the dorsal surface of the hamate. Five of the six patients also had associated posterior dislocation of the fourth and/or fifth metacarpals. We conclude that this fragment represents a coronal fracture through the body of the hamate resulting from posterior dislocation or subluxation of the fourth and/or fifth metacarpal. 相似文献
3.
4.
5.
6.
During the time from 1982/83 the intracranial pressure was continuously measured from patients who were polytraumatized and also had severe head injuries. In 53% of these cases the first readings could be obtained within 6 hours after the injury and in 33% first after 12 hours. During the time of evaluation this relationship shifted to earlier implantation. From 27% of these patients the intracranial pressure values fell into a range that instigated immediate therapeutical measures. This proves how important it is to have a direct reading from the intracranial pressure as soon as possible after injury. The aspects of therapy by increased intracranial pressure were discussed. 相似文献
7.
8.
9.
10.