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1.
ABSTRACTThis work collates data from the analysis of complex mixtures analysed in STRmix during routine no-suspect volume crime work. It interrogates the upload rate for these types of mixtures and which component of the profile has been able to be interpreted for upload. The number of profiles giving multiple uploads and the amount of replicate PCR analysis has been collated. 相似文献
2.
Vincent Laville Sigrid Le Clerc Khaled Ezzedine Randa Jdid Lieng Taing Toufik Labib Cdric Coulonges Damien Ulveling Pilar Galan Christiane Guinot Leopold Fezeu Frdrique Morizot Julie Latreille Denis Malvy Erwin Tschachler Jean‐Franois Zagury 《Experimental dermatology》2019,28(8):892-898
Sagging eyelid is considered as an outward of skin ageing and may cause medical issues. However, little is known about the factors involved in sagging eyelid. The study, which aims at determining genetic risk factors for eyelid sagging, was conducted in a cohort of 502 unrelated Caucasian women living in the Paris region. All included participants were aged between 44 and 70 years old (mean age, 57.6 years old). The severity of sagging eyelid was graded in 6 categories by a dermatologist using standardized photographs of the face. A genome wide association study adjusted on potential risk factors (including age and smoking habits) was conducted to identify genetic associations. Two single nucleotide polymorphisms in total linkage disequilibrium on chromosome 10, rs16927253 (P = 7.07 × 10‐10) and rs4746957 (P = 1.06 × 10‐8), were significantly associated with eyelid sagging severity. The rs16927253‐T and rs4746957‐A alleles showed a dominant protective effect towards eyelid sagging. These polymorphisms are located in intronic parts of the H2AFY2 gene which encodes a member of the H2A histone family and very close to the AIFM2 gene that induces apoptosis. Additionally, single nucleotide polymorphisms with a false discovery rate below 0.25 were located nearby the type XIII collagen COL13A1 gene on chromosome 10 and in the ADAMTS18 gene on chromosome 16. Several relevant genes were identified by the genome wide association study for their potential role in the sagging eyelid severity. 相似文献
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4.
This study investigates the contribution of body fat stores on the age-associated increase in serum cholesterol and triglyceride levels. Percentage of body fat was measured by hydrostatic weighing, and serum cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels were determined in a sample of 472 healthy men and women ages 18-50 years. In both sexes, body fat mass was significantly correlated with serum cholesterol (r = 0.21 in men and r = 0.24 in women, P less than 0.01) and triglyceride (r = 0.33 in men and r = 0.24 in women, P less than 0.01) levels. After adjustment for the association between age and serum cholesterol, no correlation was observed between body fat mass and serum cholesterol (r = 0.01 in men and r = 0.09 in women). After correction for age, serum triglyceride levels remained significantly correlated with body fat mass (r = 0.26 and r = 0.17 in men and women, respectively, P less than 0.05). As body fat also increases with age, the possibility that a partial correlation coefficient procedure eliminated a portion of the age effect mediated by an age-related increase in fat, was addressed by performing further analyses. Within each sex subsample two sets of analyses were performed on (a) three groups of subjects individually paired for age but with different levels of body fat stores, and (b) three groups of subjects paired for the amount of body fat but differing in age.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
5.
Background
Chronic plantar heel pain (CPHP) is one of the most common musculoskeletal disorders of the foot, yet its aetiology is poorly understood. The purpose of this study was to examine the association between CPHP and a number of commonly hypothesised causative factors. 相似文献6.
Lamine Abdennour Paola Sanchez-Pea Damien Galanaud Vincent Navarro Nicolas Weiss Louis Puybasset 《Neuropsychiatric Disease and Treatment》2007,3(5):695-702
As for the majority of antiepileptic drugs, encephalopathy, manifested by transient somnolence, mood and motor disorders, is a possible side-effect. To our knowledge, there is little information about gabapentin-induced coma. We report a third case of gabapentin-induced coma where magnetic resonance-spectrometry was performed in diagnosis assessment. 相似文献
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8.
Erythropoietin and oxidative stress in haemodialysis: beneficial effects of vitamin E supplementation 总被引:10,自引:7,他引:3
Cristol J; Bosc J; Badiou S; Leblanc M; Lorrho R; Descomps B; Canaud B 《Nephrology, dialysis, transplantation》1997,12(11):2312-2317
Oxidative stress can produce profound alterations to cellular membrane
lipids, impairing cell metabolism and viability. This phenomenon,
previously observed in haemodialysis patients, had been proposed as a
significant factor in regard to haemodialysis-related shortened red blood
cells (RBC) survival. In the present study, several parameters associated
with oxidative stress were evaluated in a group of haemodialysis patients
either receiving erythropoietin therapy (n=12, mean erythropoietin dose
88±24 U/kg/week) or not receiving such therapy (n=20), and in 38
controls. Malonyldialdehyde (MDA, nmol/ml), an end-product of lipid
peroxidation, and RBC anti-oxidant systems were measured, including RBC
&agr;-tocopherol (RBC vitamin E, mg/l), RBC glutathione (GSH,
nmol/mgHb), and RBC superoxide dismutase activity (SOD, U/mgHb). Plasma
vitamin E concentrations were also evaluated. Finally, oral vitamin E
supplementation (500 mg daily), an exogenous antioxidant, was administered
for 6 months to seven patients from the dialysis group receiving
erythropoietin while oxidative parameters were repeatedly evaluated and
erythropoietin requirements monitored, in order to appreciate the
therapeutic relevance of an antioxidant supplementation. An elevation of
serum MDA was observed in all haemodialysis patients and a significant
decrease in RBC vitamin E, despite normal serum vitamin E levels.
Furthermore, the reduction in RBC vitamin E was more important in patients
treated with erythropoietin. Vitamin E supplementation resulted in a
significant increase in RBC vitamin E (from 0.3±0.1 to
1.2±0.2 mg/l of pellet) and a reduction in erythropoietin dose
(from 93±24 to 74±26 U/kg/week) while maintaining
stable haemoglobin concentrations. These results suggest that the oxidative
stress could be one of the resistance factors to erythropoietin response in
haemodialysis and that vitamin E supplementation could have a sparing
effect on erythropoietin dosage requirement. Key
words: antioxidant; erythropoietin; haemodiafiltration; lipid
peroxidation; oxidative stress; vitamin E
相似文献
9.
The first reported case of laparoscopy site metastases from an unsuspected stage IB cervical cancer diagnosed during laparoscopy for endometriosis is presented. Implications of this clinical situation are discussed. 相似文献
10.
The acute effect of food intake on the activity of the sympathetic nervous system (SNS) in both heart and brown adipose tissue (BAT) was investigated in mice. Upon delivery to the laboratory mice were housed singly and divided into two groups. Half the mice were accustomed to eat their daily food ration in two meals whereas the other half were given continuous access to food. SNS activity in both heart and BAT was estimated by measuring the accumulation of dopamine (DA) after having blocked the transformation of dopamine into noradrenaline (NA) with 1-cyclohexyl-2-mercapto-imidazole (CHMI). CHMI inhibits the enzyme dopamine beta-hydroxylase. On the day SNS activity was assessed, continuously fed (CF) or meal-fed (MF) mice were injected with either saline or CHMI one hour before being killed. In order to assess the anticipatory effects of being fed, a group of mice already accustomed to the meal-feeding schedule were not allowed to eat after the injections. Additional CF and MF mice were killed without being injected in order to determine the basal levels of both DA and NA. The results show that the accumulation of DA in both heart and BAT was higher in MF than CF mice regardless of whether MF mice were or were not fed after the injection of CHMI. It therefore appears that the intake of food may increase SNS activity in various tissues in mice, and that such a response may be largely of cephalic origin. 相似文献