全文获取类型
收费全文 | 15969篇 |
免费 | 982篇 |
国内免费 | 103篇 |
专业分类
耳鼻咽喉 | 147篇 |
儿科学 | 339篇 |
妇产科学 | 181篇 |
基础医学 | 1861篇 |
口腔科学 | 416篇 |
临床医学 | 1133篇 |
内科学 | 4101篇 |
皮肤病学 | 509篇 |
神经病学 | 936篇 |
特种医学 | 877篇 |
外科学 | 2985篇 |
综合类 | 57篇 |
一般理论 | 2篇 |
预防医学 | 392篇 |
眼科学 | 161篇 |
药学 | 929篇 |
中国医学 | 22篇 |
肿瘤学 | 2006篇 |
出版年
2023年 | 183篇 |
2022年 | 357篇 |
2021年 | 579篇 |
2020年 | 281篇 |
2019年 | 394篇 |
2018年 | 479篇 |
2017年 | 450篇 |
2016年 | 473篇 |
2015年 | 461篇 |
2014年 | 592篇 |
2013年 | 611篇 |
2012年 | 1048篇 |
2011年 | 1091篇 |
2010年 | 572篇 |
2009年 | 472篇 |
2008年 | 800篇 |
2007年 | 914篇 |
2006年 | 823篇 |
2005年 | 810篇 |
2004年 | 687篇 |
2003年 | 605篇 |
2002年 | 569篇 |
2001年 | 339篇 |
2000年 | 318篇 |
1999年 | 329篇 |
1998年 | 152篇 |
1997年 | 113篇 |
1996年 | 119篇 |
1995年 | 68篇 |
1994年 | 84篇 |
1993年 | 59篇 |
1992年 | 220篇 |
1991年 | 186篇 |
1990年 | 167篇 |
1989年 | 155篇 |
1988年 | 185篇 |
1987年 | 153篇 |
1986年 | 120篇 |
1985年 | 136篇 |
1984年 | 94篇 |
1983年 | 87篇 |
1979年 | 72篇 |
1978年 | 58篇 |
1977年 | 46篇 |
1976年 | 40篇 |
1974年 | 43篇 |
1973年 | 46篇 |
1972年 | 51篇 |
1971年 | 39篇 |
1969年 | 45篇 |
排序方式: 共有10000条查询结果,搜索用时 359 毫秒
1.
Hori Hiroki Ohta Asuka Matsui Honami Yano Kanako Morita-Tominaka Miyuki Linn Zayar Masumoto Daisuke Okumura Yosuke Okamura Satoshi Kurihara Kosuke Hayakawa Akira Rikiishi Takeshi Kobayashi Kyoko 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(1):245-252
International Journal of Clinical Oncology - The practice of cancer diagnosis disclosure to children has been changed with the times. The regulations of clinical trials in the 2000s might change... 相似文献
2.
3.
4.
5.
Daisuke Ishii Daisuke Matsuzawa Shingo Matsuda Haruna Tomizawa-Shinohara Chihiro Sutoh Eiji Shimizu 《The International journal of neuroscience》2019,129(1):1-9
Adolescence is a vulnerable period for developing anxiety-related mental disorders such as post-traumatic stress disorder (PTSD), which requires a long-term course of therapy when a traumatic event has been experienced during childhood. However, the biological mechanism underlying these age-dependent characteristics remains unclear. In the present study, we used early adolescent, late adolescent and adult (4-, 8-, and 15-week old) male mice to examine age differences in fear memory, fear extinction, and spontaneous recovery of fear. We also measured the activation of extracellular signal-regulated kinase (ERK) 2 in the dorsal hippocampus (dHip) and the basolateral amygdala (BLA) following a spontaneous recovery test. Our major findings were as follows: (1) early adolescent and adult mice did not recover the fear response; only late adolescent mice recovered the fear response. (2) The ERK2 in the dHip was more activated after the spontaneous recovery test in late adolescent mice than in adult mice, and the ERK2 in the BLA was more activated after the spontaneous recovery test in adult mice than in late adolescent mice. These results suggest that there exists a unique period in which spontaneous recovery occurs and that these late adolescent behavioral signatures may be related to alteration in the ERK2 phosphorylation in the dHip and BLA. 相似文献
6.
Daisuke Kubota Chizuru Takishima Ken-ichi Ishii Takahiro Kawamura Tomoko Matsumoto Yasuhiro Itsui Eriko Okada Seishin Chin Shinya Oooka Kiichiro Tsuchiya Akihiro Araki Naoya Sakamoto Tatsuya Miyata Takanori Kanai Mamoru Watanabe 《Nihon Shokakibyo Gakkai zasshi》2006,103(9):1044-1049
A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level. 相似文献
7.
Yuichiro Nakai MD DMSc Takeshi Maeda MD Junko Nishio MD DMSc Daisuke Tachibana MD Motoharu Imanaka MD DMSc Sachio Ogita MD DMSc 《The Australian & New Zealand journal of obstetrics & gynaecology》1998,38(4):469-471
EDITORIAL COMMENT: We accepted this case for publication to remind readers that although uterine rupture during labour in a primigravida is extremely uncommon it does occur, or at any rate nulliparas can develop abdominal pain and shock in labour with a haemoperitoneum resulting from a tear in a vein in the lower posterior uterine wall. When one sees the hugely dilated uterine and ovarian venous plexuses at Caesarean section it is easy to believe that bleeding from such a vessel during labour could be prodigious. This case suggests that a dilated vein with blood flow derangements may be the cause. Nonetheless, as the authors warn us, the necessary response is not a precise diagnosis, but rapid laparotomy. See also Editorial Comment to Chin MMS, Harvey JA, Duffy BL. Uterine rupture during labour in a primigravida. Aust NZ J Obstet Gynaecol 1996; 36: 210. 相似文献
8.
Y. Kuroda H. Takashima A. Ikeda C. Endo R. Neshige R. Kakigi H. Shibasaki 《Journal of neurology》1991,238(6):309-314
Summary Fourteen patients with HTLV-1-associated myelopathy were treated with high-dose intravenous gammaglobulin (IVGG). Ten received 10 g/day of IVGG and 4 received 400 mg/kg of body-weight/day of IVGG for 5 consecutive days. Improvement of spastic paraparesis was observed in 10 within 7 days of the commencement of IVGG. The therapeutic effects were sustained for more than 3 weeks in some patients. There were no side effects. Analysis of factors of relevance to the clinical improvement with IVGG showed that the beneficial response was preferentially found in patients having a high CSF titre of anti-HTLV-I antibodies, a high CSF IgG level and a marked brain MRI abnormality. 相似文献
9.
Prolidase was highly purified from human liver and erythrocytes. NaDodSO4/acrylamide gel electrophoresis revealed that these preparations contained a major protein with MW = 56,000. The mass of prolidase was estimated on gel filtration to be MW = 97,000, for both enzyme preparations. A monoclonal antibody was raised against the liver enzyme and a specific antiserum against the erythrocyte enzyme. The monoclonal antibody (EP-2) recognized prolidase from erythrocytes and liver, in equal proportions. The antiserum also recognized the enzyme from erythrocytes and liver. Immunoprecipitation studies with these antibodies suggested only a single species of prolidase in erythrocytes and liver. Using an immobilized monoclonal antibody (EP-2) as an immunoadsorbent, prolidase was partially purified from crude extracts, and the protein of the partially purified enzyme was identified by immunoblotting using antiserum. A protein band with a MW = 56,000 was demonstrated specifically when crude extracts from the liver and erythrocytes were examined using NaDodSO4/acrylamide gel electrophoresis. The subunit protein was absent in erythrocytes from a patient with prolidase deficiency. We propose that the absence of the subunit is one cause of the prolidase deficiency. 相似文献
10.
The correlation between the treadmill exercise test results and the hemodynamic data of 152 patients with previous myocardial infarction were investigated. The patients were classified into 4 groups as follows: H1 left ventricular end-diastolic pressure (LVEDP) less than or equal to 12 mmHg and cardiac index (CI) greater than or equal to 3.0 L/min/m2; H2 LVEDP greater than 12 mmHg and CI greater than or equal to 3.0 L/min/m2; H3 LVEDP less than or equal to 12 mmHg and CI less than 3.0 L/min/m2; and H4 LVEDP greater than 12 mmHg and CI less than 3.0 L/min/m2. The duration of the exercise was significantly shortened for group H4 than group H1 (p less than 0.01). The maximal ST segment elevation (mSTe) was significantly increased for group H3 and group H4, versus group H1 (p less than 0.05). The number of ST segment elevations and mSTe/maximal heart rate were significantly increased for group H3 (p less than 0.05) and group H4 (p less than 0.01) versus group H1. The incidence of exercise-induced premature ventricular contractions (PVCs) was significantly increased in group H3 and group H4, versus group H1 (p less than 0.05). There were no significant differences in the maximal heart rate, double product, and ST segment depression among the 4 groups. Our data indicate that the groups with impaired left ventricular functions tend to decrease the duration of the exercise and to increase ST segment elevation and PVC frequencies during exercise. 相似文献