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排序方式: 共有107条查询结果,搜索用时 15 毫秒
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Kozaki Yohei Morinaga Takatoshi Fukatsu Atsushi Ito Takeshi Ishimoto Takuji Kosugi Tomoki Inaguma Daijo Tamai Hirofumi Maruyama Shoichi 《Clinical and experimental nephrology》2022,26(5):466-475
Clinical and Experimental Nephrology - A Dialysis Outcomes and Practice Patterns Study (DOPPS) has shown a one-to-one male-to-female mortality ratio, notwithstanding the statistically longer life... 相似文献
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Eri Koshi‐Ito Kiyomi Koike Akihito Tanaka Yu Watanabe Naoki Kamegai Hiroya Shimogushi Hibiki Shinjo Yasuhiro Otsuka Daijo Inaguma Asami Takeda 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2019,23(6):575-583
Low‐density lipoprotein apheresis (LDL‐A) has been used for nephrotic syndrome (NS) caused by focal segmental glomerulosclerosis in Japan. Idiopathic membranous nephropathy (iMN) can also cause treatment‐resistant NS. Therefore, we investigated the effect of LDL‐A during initial induction for it. This retrospective, observational, and single‐center study enrolled consecutive iMN patients who received steroids from March 2000 to May 2015. We compared data between 11 patients treated with LDL‐A (LDL‐A group) and 27 patients without (non‐LDL‐A group) at baseline and 4 and 8 weeks later. Reduction rate of proteinuria and increase rate of serum albumin in LDL‐A group were significantly higher than the other after 4 weeks (P = 0.036 and 0.030) and 8 weeks (P = 0.030 and <0.001), respectively. There was no adverse event caused by LDL‐A and immunosuppressant dose was not significantly different. In conclusion, LDL‐A may be an effective choice for initial induction of nephrotic iMN. 相似文献
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Nobuo Murata Hideyuki Ishida Youichiro Makita Akio Odaka Kazuyuki Shimomura Kuniyasu Takahashi Daijo Hashimoto Yasuo Idezuki 《Surgery today》2003,33(4):259-263
Purpose: We examined muscle strength and walking ability after hernia repair to compare the effects of laparoscopic hernioplasty and
conventional repair.
Methods: Twenty-seven patients with primary inguinal hernias were randomly divided into two groups according to the surgical procedure:
15 patients were treated with laparoscopic hernioplasty and 12 with conventional repair. Two types of muscle testing around
the inguinal region, one by manual examination and one using a musculator, were done preoperatively and 1 week postoperatively.
Walking exercise tests were performed at the same time as muscle testing.
Results: Manual examination showed that the postoperative muscle strength of the iliopsoas muscle was decreased in six patients from
the conventional repair group, but not in any of those from the laparoscopic hernioplasty group. The musculator showed decreased
strength of the iliopsoas muscle after conventional repair, but not after laparoscopic hernioplasty. The walking exercise
test showed that conventional hernia repair influenced walking.
Conclusion: A decline in muscle strength of the iliopsoas muscle and walking ability was evident after conventional repair, but not after
laparoscopic hernioplasty. Thus, laparoscopic hernioplasty is superior to conventional repair from the perspective of muscle
testing and walking ability.
Received: March 29, 2002 / Accepted: July 2, 2002
Reprint requests to: N. Murata 相似文献
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Ishida H Takeuchi I Ohsawa T Nakada H Ishizuka N Yokoyama M Inokuma S Suzuki T Yamada H Odaka A Hoshino T Murata N Hashimoto D Matsumoto Y Miura T 《Gan to kagaku ryoho. Cancer & chemotherapy》2002,29(12):2267-2270
PURPOSE: The purpose of this study was twofold: (1) to disclose the intermediate outcome of a non-randomized trial of prophylactic hepatic arterial infusion chemotherapy (PHAI) for curatively resected Dukes' C colorectal cancer performed between November 1996 and April 2000, and (2) to examine the relationship between the expression of dihydropyrimidine dehydrogenase (DPD) in tumor tissue and the efficacy of this chemotherapy. PATIENTS AND METHODS: The oncological outcomes were compared between patients (n = 28) receiving PHAI (5-FU: 500 mg/body/w x 50 cycles) plus oral administration of UFT-E (400 mg/body/day, for 24 months) and those (n = 21) receiving UFT-E alone. The levels of tumoral DPD were determined in a total of 43 patients (n = 25, PHAI group; n = 18, control group) by an enzyme-linked immunosorbent assay. RESULTS: Seven (25%) in the PHAI group and four (19%) in the control group developed liver metastasis postoperatively. The liver metastasis-free survival was not different between the groups (p = 0.94). When the analysis was restricted to patients who developed liver metastasis, the duration from surgery to detecting liver metastasis tended to be longer in the PHAI group (p = 0.09). In addition, the overall survival tended to be better in the PHAI group (p = 0.12). In the control group, the level of DPD was higher in patients who developed liver metastases (n = 4) than in those who did not (n = 14, p = 0.04). However, in the PHAI group, the level of DPD was not different regardless of the occurrence of liver metastases (p = 0.30). CONCLUSIONS: These results suggest that (1) PHAI is unlikely to improve the prognosis of Dukes' C patients remarkably, and (2) the efficacy of this regimen cannot be predicted by determining the levels of tumoral DPD. 相似文献
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Odaka A Takahashi S Tanimizu T Kawashima H Inokuma S Ishida H Hoshino T Baba K Tamura M Satomi A Hashimoto D 《Journal of pediatric surgery》2005,40(5):e5-e7
We report on an extremely rare chest wall mesenchymal hamartoma associated with a massive fetal pleural effusion. Prenatal ultrasound examination demonstrated a heterogeneous mass in the right thorax associated with a massive pleural effusion and right lung compression at 29 weeks of gestation. The patient underwent pleuroamniotic shunting at 30 weeks and was delivered at 33 weeks by cesarean delivery secondary to fetal distress. After management of the respiratory distress and evaluation of the mass, surgery was performed at day of life 8. Histological examination confirmed the diagnosis of a chest wall mesenchymal hamartoma. 相似文献
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Takeuchi I Ishida H Hashimoto D Mastumoto Y Miura T 《Gan to kagaku ryoho. Cancer & chemotherapy》2003,30(11):1686-1688
OBJECTIVE: Recently, for the treatment of unresectable colorectal cancer with liver metastasis, hepatic artery injection of anticancer drugs suspended in degradable starch microspheres (DSM) is being performed. To predict its effectiveness, we did a retrospective study to see whether or not changes in CEA at early stages of therapy are significant. SUBJECTS AND METHOD: The subjects were 16 patients with unresectable colorectal cancer with liver metastasis (H3) who had undergone DSM therapy at least three times (mean age 65, male to female ratio of 10:6, 6 cases of synchronous metastasis and 10 cases of metachronous metastasis). Adriamycin (ADM) 30 mg and mitomycin C (MMC) 10 mg were suspended in 600 mg of DSM and injected into the common hepatic artery until embolization of the vessel was recognized (once/3-4 weeks). We examined the changes in CEA level (doubling time or half time) and the time to progression (TTP) of CEA after the third DSM treatment. RESULTS: Of the 16 patients, 4 (25%) showed rise in CEA, of which 3 died within a year. In the 12 cases with decreased CEA, the half time was 20-526 days (mean of 80 days). When the TTP of CEA was compared for the group with CEA half time less than 80 days (n = 6) to those with more then 80 days (n = 6), the TTP was significantly longer in the group with half time less than 80 days (p = 0.02 logrank test). CONCLUSION: To evaluate the effectiveness of DSM therapy, it is important to examine the changes in CEA at the early stages of treatment. 相似文献
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Inflammatory breast cancer: Vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model
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Shirakawa K Kobayashi H Sobajima J Hashimoto D Shimizu A Wakasugi H 《Breast cancer research : BCR》2003,5(3):136-139
We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the central part of the solid nests, vasculogenic mimicry, which showed an absence of endothelial cells, was observed. Comparison of WIBC-9 with an established non-IBC xenograft (MC-5), using time-course dynamic micro-magnetic resonance angiography analysis (with a newly developed intravascular macromolecular contrast agent for magnetic resonance imaging) demonstrated that the WIBC-9 tumor had blood flow and a vascular mimicry-angiogenesis junction. 相似文献
10.
Serum Levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) in Colorectal Cancer Patients 总被引:1,自引:0,他引:1
Purpose Expression of tissue inhibitor of metalloproteinases (TIMP)-1 in colorectal cancer tissue is known to be related to disease progression; however, the clinical significance of measuring the blood level of TIMP-1, which we evaluate herein, has not yet been clarified.Methods The serum level of TIMP-1 was measured by a one-step enzyme immunoassay in 123 patients who underwent resection of primary colorectal cancer.Results An elevated level of serum TIMP-1 was associated with advanced Dukes stage (P = 0.03), greater diameter of the primary tumor (P = 0.03), more lymph node metastasis (P = 0.04), and liver metastasis (P 0.001). There was a weakly positive correlation between the serum carcinoembryonic antigen (CEA) level and the serum TIMP-1 level. In patients who underwent potentially curative resection, the disease-free survival was not different between those with a high TIMP-1 level (203.5ng/ml, n = 32) and those with a low TIMP-1 level (203.5ng/ml, n = 66, P = 0.62). In patients with Dukes stage D cancer who underwent noncurative resection, the survival times were not different between those with a high TIMP-1 level (n = 13) and those with a low TIMP-1 level (n = 10, P = 0.20).Conclusions Elevated levels of serum TIMP-1 reflect the extent of colorectal cancer, without a close correlation with the serum CEA level. These findings suggest that measuring the serum TIMP-1 level would not help to predict the prognosis of patients with colorectal cancer. 相似文献