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1.
A R Dias R N Melo O C E Gebara E A D'Amico A Nussbacher H W Halbe J A Pinotti 《Climacteric》2005,8(1):63-70
OBJECTIVES: To compare the effect of conjugated equine estrogens (CEE) and raloxifene on lipid profile and hemostasis. MATERIALS AND METHODS: A double-blind, randomized and parallel study was performed with 90 healthy postmenopausal women, aged 54 +/- 5 years, divided into three groups and submitted to daily therapy with either CEE 0.625 mg, raloxifene 60 mg or placebo for 4 months. The lipid profile, coagulation and fibrinolytic factors were analyzed. RESULTS: CEE increased the levels of high density lipoprotein cholesterol (HDL-C) from 49.0 to 56.8 mg/dl (p < 0.001), very low density lipoprotein cholesterol (VLDL-C) from 17.2 to 22.3 mg/dl (p < 0.001), and triglycerides from 86.0 to 111.7 mg/dl (p < 0.001), and decreased the levels of low density lipoprotein cholesterol (LDL-C) from 121.0 to 106.5 mg/dl (p < 0.001). The only significant effect of raloxifene was an increase in the levels of HDL-C from 46.0 to 47.8 mg/dl (p = 0.019). There was no significant reduction in LDL-C, from 115.5 to 110.2 mg/dl (p = 0.06), VLDL-C, from 21.7 to 20.0 mg/dl (p = 0.201), and triglycerides, from 108 to 100 mg/dl (p = 0.201). CEE decreased the levels of fibrinogen, from 370.5 to 326.8 g/l (p = 0.039) and the levels of antithrombin III, from 99.5 to 93.2% (p < 0.001). Raloxifene decreased the levels of fibrinogen, from 354.7 to 302.0 g/l (p = 0.009) and the levels of antithrombin III, from 102.4 to 98.5% (p = 0.039). CEE increased levels of protein C from 103.7 to 115.3 mg/l (p < 0.001) and raloxifene did not change the levels of protein C (107.9 to 105.1 mg/l; p = 0.158). CEE decreased the antigen levels of tissue plasminogen activator (t-PA) from 8.8 to 6.8 U/ml (p < 0.001), and of plasminogen activator inhibitor (PAI-1) from 30.8 to 21.6 U/ml (p < 0.010), whereas raloxifene had no significant effect on either t-PA, from 9.6 to 9.2 U/ml (p = 0.235) or PAI-1 antigen levels, from 32.1 to 30.4 U/ml (p = 0.538). CONCLUSION Both CEE and raloxifene exert significant effects on the lipid and coagulation profile. CEE had a more significant effect on fibrinolysis than raloxifene. These effects may have a significant impact on the cardiovascular risk that needs to be confirmed in larger studies. 相似文献
2.
Giant aneurysm of the pericallosal artery 总被引:1,自引:0,他引:1
A rare case of a giant aneurysm of the pericallosal artery, evaluated by computed tomography, magnetic resonance imaging, and angiography, is reported, and the other 7 cases in the literature are reviewed. Giant aneurysms are exceptional in the distal segments of the anterior cerebral arteries, and may simulate a callosal tumor or hematoma on computed tomographic scan. The clinical, radiological, surgical, and pathological findings of giant aneurysms of this location are discussed and the other reported cases are analyzed. The role of magnetic resonance imaging in diagnosing and characterizing giant aneurysms is stressed. 相似文献
3.
After describing the stages of surgical infection and the efficacy of short-term antibiotic prophylaxis in surgery, the paper reports a trial in which a single dose of Ceftriaxone was administered in 50 cases of cholecystectomy, with excellent results in terms of efficacy and tolerability. 相似文献
4.
Giangennaro Coppola Francesca Felicia Operto Gianfranca Auricchio Alessandra D'Amico Delia Fortunato Antonio Pascotto 《Epileptic Disord》2007,9(2):145-148
A child had the characteristic clinical and EEG pattern of migrating partial seizures in infancy with left temporal lobe atrophy, hippocampal sclerosis and cortical-subcortical blurring.Seizures were drug-resistant, with recurring episodes of status epilepticus. The child developed microcephaly with arrest of psychomotor development. Focal brain lesions, in the context of migrating partial seizures, have not been previously reported.[Published with video sequences]. 相似文献
5.
Characterization of nephropathy induced by immunization with high molecular weight dextran 总被引:1,自引:0,他引:1
Pasi A; Dendorfer U; Holthofer H; Nelson P; Tazzari S; Armelloni S; Fornasieri A; D'Amico G; Schlondorff D 《Nephrology, dialysis, transplantation》1997,12(9):1849-1855
Background. Injection of DEAE dextran into Lewis rats
can produce proteinuria and has been reported as a model of IgA
nephropathy. Methods. Cationic diethyl aminoethyl
(DEAE) dextran of molecular weight 500 KDa was injected into male Lewis
rats. After a pre-immunization period of 3 weeks, the animals were divided
into two groups: group 1 (n=14) received daily i.v. injections of 3.5 mg of
antigen, group 2 (n=14) was injected with 1.5 mg three times per week for a
total period of 6 weeks. I.v. treatment was initiated with gradually
increasing doses of DEAE dextran in both groups for 1 week, after which the
maintenance dose was reached. Results. We observed the
appearance of proteinuria in a nephrotic range after 5 weeks of i.v.
injections in group 1 (urinary excretion: 332±83 mg/24 h,
controls: 53±14 mg/24 h). In group 2, the proteinuria was almost
equal to protein excretion of healthy rats of the same weight
(67±20 mg/24 h). The serum and urine creatinine were normal. By
light microscopy of kidney biopsies, the presence of focal and segmental
proliferation of mesangial cells after 6 weeks of i.v. injections was
identified. Immunohistochemistry revealed no deposition of IgA, IgM, IgG,
or C3. Using anti-ED1 antibodies, there was no evidence of interstitial
infiltration of monocytes/macrophages after 6 weeks of i.v. injections.
Staining for proliferating cell nuclear antigen (PCNA) did not show the
presence of proliferating cells either in glomeruli or in the interstitium.
Staining with FITC-WGA lectin revealed focal and segmental loss of the
negative charge in the capillary wall. By electron microscopy there was
deposition of dextran in the basal membrane and segmental and focal damage
of the podocyte foot processes. As the chemokine RANTES may be involved in
glomerular injury, we examined the kidneys of proteinuric and
non-proteinuric rats for the presence of RANTES. By indirect
immunofluorescence only the proteinuric rats showed RANTES deposition in
mesangium. Conclusions. Injection of rats with DEAE
dextran leads to dose-dependent proteinuria without deposition of immune
complexes but with podocyte damage. This is associated with local
expression of the chemokine RANTES which may play a role in proteinuria of
glomerular disease. 相似文献
6.
7.
The commonest glomerulonephritis in the world: IgA nephropathy 总被引:38,自引:0,他引:38
G D'Amico 《The Quarterly journal of medicine》1987,64(245):709-727
8.
9.
10.
D'Amico G Frascaroli G Bianchi G Transidico P Doni A Vecchi A Sozzani S Allavena P Mantovani A 《Nature immunology》2000,1(5):387-391
As originally demonstrated for the interleukin 1 (IL-1) type II receptor, some primary proinflammatory cytokines from the IL-1 and tumor necrosis factor families are regulated by decoy receptors that are structurally incapable of signaling. Here we report that concomitant exposure to proinflammatory signals and IL-10 generates functional decoy receptors in the chemokine system. Inflammatory signals, which cause dendritic cell (DC) maturation and migration to lymphoid organs, induce a chemokine receptor switch, with down-regulation of inflammatory receptors (such as CCR1, CCR2, CCR5) and induction of CCR7. Concomitant exposure to lipopolysaccharide (LPS) and IL-10 blocks the chemokine receptor switch associated with DC maturation. LPS + IL-10-treated DCs showed low expression of CCR7 and high expression of CCR1, CCR2 and CCR5. These receptors were unable to elicit migration. We provide evidence that uncoupled receptors, expressed on LPS + IL-10-treated cells, sequester and scavenge inflammatory chemokines. Similar results were obtained for monocytes exposed to activating signals and IL-10. Thus, in an inflammatory environment, IL-10 generates functional decoy receptors on DC and monocytes, which act as molecular sinks and scavengers for inflammatory chemokines. 相似文献