全文获取类型
收费全文 | 1818篇 |
免费 | 173篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 42篇 |
妇产科学 | 25篇 |
基础医学 | 179篇 |
口腔科学 | 125篇 |
临床医学 | 245篇 |
内科学 | 529篇 |
皮肤病学 | 24篇 |
神经病学 | 149篇 |
特种医学 | 113篇 |
外科学 | 169篇 |
综合类 | 49篇 |
预防医学 | 120篇 |
眼科学 | 15篇 |
药学 | 54篇 |
中国医学 | 1篇 |
肿瘤学 | 124篇 |
出版年
2023年 | 13篇 |
2021年 | 35篇 |
2020年 | 30篇 |
2019年 | 32篇 |
2018年 | 37篇 |
2017年 | 33篇 |
2016年 | 23篇 |
2015年 | 36篇 |
2014年 | 50篇 |
2013年 | 81篇 |
2012年 | 62篇 |
2011年 | 80篇 |
2010年 | 66篇 |
2009年 | 54篇 |
2008年 | 57篇 |
2007年 | 75篇 |
2006年 | 52篇 |
2005年 | 68篇 |
2004年 | 71篇 |
2003年 | 44篇 |
2002年 | 42篇 |
2001年 | 32篇 |
2000年 | 43篇 |
1999年 | 39篇 |
1998年 | 36篇 |
1997年 | 45篇 |
1996年 | 34篇 |
1995年 | 30篇 |
1994年 | 27篇 |
1993年 | 24篇 |
1992年 | 44篇 |
1991年 | 17篇 |
1990年 | 34篇 |
1989年 | 30篇 |
1988年 | 35篇 |
1987年 | 42篇 |
1986年 | 37篇 |
1985年 | 38篇 |
1984年 | 27篇 |
1983年 | 23篇 |
1982年 | 30篇 |
1981年 | 18篇 |
1980年 | 24篇 |
1979年 | 18篇 |
1978年 | 29篇 |
1977年 | 22篇 |
1976年 | 33篇 |
1975年 | 26篇 |
1974年 | 21篇 |
1973年 | 18篇 |
排序方式: 共有1997条查询结果,搜索用时 15 毫秒
1.
2.
Platelet activation: role of an ADP receptor 总被引:3,自引:0,他引:3
R W Colman 《Seminars in hematology》1986,23(2):119-128
3.
Background
Pulmonary dysfunction following cardiac surgery is believed to be caused, at least in part, by a lung vascular injury and/or atelectasis following cardiopulmonary bypass (CPB) perfusion and collapse of non-ventilated lungs. 相似文献4.
Carel Bron Michel Wensing Jo LM Franssen Rob AB Oostendorp 《BMC musculoskeletal disorders》2007,8(1):107
Background
Shoulder disorders are a common health problem in western societies. Several treatment protocols have been developed for the clinical management of persons with shoulder pain. However available evidence does not support any protocol as being superior over others. Systematic reviews provide some evidence that certain physical therapy interventions (i.e. supervised exercises and mobilisation) are effective in particular shoulder disorders (i.e. rotator cuff disorders, mixed shoulder disorders and adhesive capsulitis), but there is an ongoing need for high quality trials of physical therapy interventions. Usually, physical therapy consists of active exercises intended to strengthen the shoulder muscles as stabilizers of the glenohumeral joint or perform mobilisations to improve restricted mobility of the glenohumeral or adjacent joints (shoulder girdle). It is generally accepted that a-traumatic shoulder problems are the result of impingement of the subacromial structures, such as the bursa or rotator cuff tendons. Myofascial trigger points (MTrPs) in shoulder muscles may also lead to a complex of symptoms that are often seen in patients diagnosed with subacromial impingement or rotator cuff tendinopathy. Little is known about the treatment of MTrPs in patients with shoulder disorders. 相似文献5.
6.
Inhibition of angiogenesis by antibody blocking the action of proangiogenic high-molecular-weight kininogen 总被引:7,自引:1,他引:6
R. W. Colman R. A. Pixley I. M. Sainz J. S. Song I. Isordia-Salas S. N. Muhamed † J. A. Powell Jr † S. A. Mousa† 《Journal of thrombosis and haemostasis》2003,1(1):164-170
Summary. Previously we demonstrated that domain 5 (D5) of high-molecular-weight kininogen (HK) inhibits neovascularization in the chicken chorioallantoic membrane (CAM) assay and further found that kallikrein cleaved HK (HKa) inhibited FGF2-and VEGF-induced neovascularization, and thus was antiangiogenic. In this study, we sought to demonstrate whether uncleaved HK stimulates neovascularization and thus is proangiogenic. The chick chorioallantoic membrane was used as an in ovo assay of angiogenesis. Low-molecular-weight kininogen stimulates angiogenesis, indicating that D5 is not involved. Bradykinin stimulates neovascularization equally to HK and LK and is likely to be responsible for the effect of HK. A murine monoclonal antibody to HK (C11C1) also recognizes a similar component in chicken plasma as detected by surface plasmon resonance. Angiogenesis induced by FGF2 and VEGF is inhibited by this monoclonal antibody and is a more potent inhibitor of neovascularization induced by VEGF than an integrin αv β3 antibody (LM 609). Our postulate that C11C1 inhibits the stimulation of angiogenesis by HK was confirmed when either C11C1 or D5 completely inhibited angiogenesis in the CAM induced by HK. Growth of human fibrosarcoma (HT-1080) on the CAM was inhibited by GST-D5 and C11C1. These results indicate HK is proangiogenic probably by releasing bradykinin and that a monoclonal antibody directed to HK could serve as an antiangiogenic agent with a potential for inhibiting tumor angiogenesis and other angiogenesis-mediated disorders. 相似文献
7.
8.
W Colman 《The American journal of occupational therapy》1992,46(3):260-266
Since the mid-1960s, occupational therapy has maintained a multiple-entry-route educational system that provides professional preparation leading to certification for a variety of candidates. This paper focuses on the 1970s and recounts a time marked by exploration of an assortment of entry-level routes that embraced the concept of laddering and included proficiency testing and career mobility programs. The paper reviews the educational debates that occurred while occupational therapy tested the limits of innovative educational mechanisms. Although the American Occupational Therapy Association debated new options for professional preparation and temporarily instituted one additional educational avenue in those years, by 1982 its educational system returned to its mid-1960s design. 相似文献
9.
TP Amadeu† AB Seabra‡ MG de Oliveira‡ AMA Costa† 《Journal of the European Academy of Dermatology and Venereology》2007,21(5):629-637
BACKGROUND: Nitric oxide (NO) plays a key role in wound repair and S-nitrosothiols like S-nitrosoglutathione (GSNO) are well known NO donors. METHODS: Animals were separated in two groups and submitted to excisional wounds on the dorsal surface at the first day. GSNO (100 microm)-containing hydrogels were topically applied on the wound bed in the GSNO group, daily, during the first 4 days. Control group was topically treated with hydrogel without GSNO for the same period. Wound contraction and re-epithelialization were measured. Animals were sacrificed 21 days after wounding. Samples of lesion and normal tissue were formalin-fixed, paraffin embedded for histological analysis. RESULTS: Wound contraction, measured 14 and 21 days after wounding, was greater in the GSNO group than in the control group (P<0.05 for both). The re-epithelialized wound area, measured 14 days after wounding, was higher in the GSNO group than in the control group (P<0.05). A higher amount of inflammatory cells was observed in superficial and deep areas of the granulation tissue of the control group compared to the GSNO group. Twenty-one days after wounding, thin red-yellow collagen fibers arranged perpendicularly to the surface were found in the granulation tissue of the control group, whereas in the GSNO-treated group collagen fibers were thicker and arranged parallel to the surface. Increased number of mast cells was observed in the GSNO group compared with that in the control group. Vascularization and myofibroblast distribution were similar in both groups. CONCLUSION: Topical application of GSNO-containing hydrogel during the early phases of rat cutaneous wound repair accelerates wound closure and re-epithelialization and affects granulation tissue organization. 相似文献
10.