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The patellofemoral joint in total condylar knee arthroplasty. Pros and cons based on five- to ten-year follow-up observations 总被引:5,自引:1,他引:4
C S Ranawat 《Clinical orthopaedics and related research》1986,(205):93-99
In this report, 100 knees in 77 patients, with an average age of 65, were followed for a period between five and 10 years. Rheumatoid arthritis was the diagnosis in 43 patients and osteoarthritis in 34 patients. The majority had varus, valgus, and biplane deformities. Twenty-one patients underwent bilateral procedures; all but one had patellar replacement. Over 90% of the knees were rated good to excellent according to The Hospital for Special Surgery Knee Disability Score Sheet. Of the 34 osteoarthritic patients (40 knees), 24 or 71% could walk ten blocks and beyond. Ten patients, or 29%, could walk between one and ten blocks. Further ambulation was restricted only by overall poor health and age (most were 74 years of age or older). Twenty-four patients, or 71%, could ascend and descend stairs without support, while six (18%) relied on bannister support when descending stairs. Four patients (11%) required bannister support for both ascending and descending stairs. Among the complications seen in this series were one loose patella and another with osteonecrosis of the anterior surface. No dislocations occurred, but 14 patellae showed tilt on skyline view roentgenograms, indicating a tight lateral retinaculum. In view of the good to excellent results achieved in the majority of patients, and the low morbidity associated with replacement, it is recommended that the patellofemoral joint be replaced in the course of total knee arthroplasty. When careful attention is paid to technical details, this procedure improves the quality of the arthroplasty. 相似文献
3.
Specific bioactivities of monocyte-derived interleukin 1 alpha and interleukin 1 beta are similar to each other on cultured murine thymocytes and on cultured human connective tissue cells. 总被引:9,自引:2,他引:7
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E A Rupp P M Cameron C S Ranawat J A Schmidt E K Bayne 《The Journal of clinical investigation》1986,78(3):836-839
In this report we compare the bioactivities of pure, human monocyte-derived interleukin 1 (IL-1) alpha and beta in the standard murine thymocyte proliferation assay, a human dermal fibroblast proliferation assay, and in an assay measuring stimulation of prostaglandin E2 (PGE2) release from human rheumatoid synoviocytes. In each case the different species of IL-1 produced saturable stimulation and gave similar dose response curves. Half-maximal stimulation was observed at average IL-1 concentrations of 29 pM in the thymocyte assay, 2 pM in the dermal fibroblast proliferation assay, and 5 pM in the synovial cell assay. Our results show that native, monocyte-derived IL-1 alpha and IL-1 beta are both potent stimulators of connective tissue cells and that the specific bioactivities of these molecules are similar to each other in tests on human connective tissue cells, as well as on murine lymphoid cells. 相似文献
4.
Ranawat CS 《Journal of the Southern Orthopaedic Association》1999,8(4):285-287
I have put together some of the elements that will allow a person to advance and succeed in life. On a personal note, I would not be where I am without the support of my parents, teachers, colleagues, residents, and fellows. Special appreciation goes to my wife, my children, and my office staff. Without their support, this story would be incomplete. Thank all of you for putting your trust in me. 相似文献
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The clinical application of cisplatin (CP), one of the most extensively used antineoplastic drug, is restricted by its numerous side effects. CP's antitumor potential resides in the free generation of reactive oxygen species leading to oxidative stress. This stress is a source of the side effects associated with its use. Ellagic acid (EA), a polyphenol is known to possess multiple health benefits owing to its antioxidant properties. EA is largely metabolized by the colon microbiota of different mammals and therefore was a polyphenol of choice in the present study. The present study was thus carried out to explore the protective potential of EA on CP induced hepatotoxicity in colon tumor bearing mice. The administration of EA (10 mg/kg bwt po daily for 6 weeks) significantly ameliorated the toxicity caused by CP (5 mg/kg bwt ip once a week for 4 weeks). Activities of liver marker enzymes and lactate dehydrogenase were brought back to normal. EA cotreatment also led to a marked reduction in the extent of peroxidative damage to liver tissue as was evident from the improvement in the histopathological changes observed and FT‐IR analysis. The present study, therefore, suggests that the administration of EA reduces the CP‐induced hepatotoxicity, thereby emerging out as a potential candidate for chemopreventive action. 相似文献
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Morteza Meftah Mario John Matin Lendhey Aleksandr Khaimov Amar S. Ranawat Chitranjan S. Ranawat 《The Journal of arthroplasty》2013
The aim of this study was to assess peri-operative complications, safety and efficacy of non-cemented femoral fixation in total hip arthroplasty (THA) as compared to cemented femoral fixation in the elderly population. Fifty-two matched pair analysis of patients with 75 years of age and older (104 patients), who underwent primary THA from June 1997 to December 2004, was performed based on age, sex, BMI, and Charnley classification. Mean age was 81 years (75–101) and the average follow up was 3.1 ± 2.9 years (1.2–6.4). There was no difference in peri-operative cardiopulmonary complications, pulmonary failures, deep venous thrombosis, pulmonary embolus, length of stay, or discharge deposition between the two groups. Non-cemented fixation is safe and effective in patients older than 75 years of age. 相似文献
9.
Benedict U. Nwachukwu Joshua Adjei Samir K. Trehan Brenda Chang Kelms Amoo-Achampong Joseph T. Nguyen Samuel A. Taylor Frank McCormick Anil S. Ranawat 《HSS journal》2016,12(3):272-277