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排序方式: 共有245条查询结果,搜索用时 328 毫秒
1.
Stepanova E. S. Makarenkova L. M. Chistyakov V. V. Rybakov Yu. L. Gukasov V. M. Fedotcheva T. A. Parshin V. A. Votyakov V. A. Shimanovskii N. L. 《Pharmaceutical Chemistry Journal》2019,52(12):1016-1020
Pharmaceutical Chemistry Journal - An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was... 相似文献
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Y. O. Karatasso I. V. Logunova M. G. Sergeeva E. N. Nikolaev S. D. Varfolomeev V. V. Chistyakov 《Pharmaceutical Chemistry Journal》2007,41(3):166-169
A highly sensitive method for the quantitative determination of a potential antiarrhythmic drug (OF-7976) in the blood plasma
has been developed. The method is based on the electron spray ionization/mass spectrometry (ESI-MS) technique without preliminary
chromatographic separation and makes use of nibentan as the internal standard. A linear relationship between drug concentration
and the peak intensity of ions of the analyzed substance (m/z = 398) and the internal standard (m/z = 382) is established. The detection limit is 3 ng/(0.5 ml plasma). The method is linear from 3 to 25 ng/(0.5 ml plasma)
with a correlation coefficient of 0.98. The coefficient of variation was less than 7 %.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 3, pp. 45–48, March, 2007. 相似文献
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Neuroimaging in Pineal Tumors 总被引:4,自引:0,他引:4
F Reis MD AV Faria MD PhD VA Zanardi MD PhD JR Menezes MD F Cendes MD PhD LS Queiroz MD PhD 《Journal of neuroimaging》2006,16(1):52-58
BACKGROUND AND PURPOSE: The authors report radiological findings in 11 tumors in the pineal region, which were histologically diagnosed as germinomas, pineocytomas pineoblastomas, ependymomas, teratomas, and astrocytomas. METHODS: Computed tomography (CT) was performed in seven patients and magnetic resonance imaging (MRI) was performed in all patients. RESULTS: CT showed a solid or solid/cystic mass with variable contrast enhancement. MRI showed a heterogeneous mass, with hypointense signal on T1 and iso/hyperintense signal on T2-weighted images (WI) and gadolinium enhancement. Extension to adjacent structures occurred in five patients and spread through the cerebral spinal fluid (CSF) in two. CONCLUSIONS: Pineal region tumors have no pathognomonic imaging pattern. MRI and CT are complementary in diagnosis and are important to determine localization, extension, and meningeal spread. 相似文献
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A.V. Chistyakov J.F. Soustiel H. Hafner M. Elron M. Feinsod 《Acta neurochirurgica》1998,140(5):467-462
Summary
This study attempts to find out whether the motor evoked potential (MEP) elicited by single pulse and slow-rate (1 Hz) repetitive
transcranial magnetic stimulation (TMS) can disclose concealed subclinical impairments in the cerebral motor system of patients
with minor head injury.
The motor response to single pulse TMS (STMS) of the patient groups was characterized by significantly higher threshold compared
with that of the control group. The central motor conduction time, as well as the peripheral conduction time were normal in
all patients pointing to cortical impairment.
Two main patterns of MEP changes in response to repetitive TMS (RTMS) were observed in the patient group. A. – progressive
decrease of the MEP amplitude throughout the stimulation session to a near complete abolition. B. – irregularity of the amplitude
and the waveform of the MEP in a chaotic form. The MEP latency remained stable during the whole stimulation session. The MEP
abnormalities recovered gradually over the period of a few months.
The higher threshold of the motor response to STMS and the abnormal patterns of the MEP to RTMS seem to reflect transient
impairment of cortical excitability or “cortical fatigue” in patients who sustained minor head injures. Further study is needed
to evaluated the extent and the pathophysiological mechanisms of the central nervous system fatigue phenomenon following head
injury. 相似文献
8.
Myo-inositol transport in the central nervous system 总被引:18,自引:0,他引:18
9.
Labial adhesions are usually seen in early childhood or in the postmenopausal years, but this clinical entity is rarely seen in the reproductive years. We report a case of labial adhesion with acute urinary retention secondary to Bartholin's abscess in a reproductive‐aged woman with normal menstrual periods. We emphasize the possible occurrence of labial adhesion following Bartholin's abscess in the reproductive years with normal estrogen levels. 相似文献
10.
Warkentin TE; Hayward CP; Boshkov LK; Santos AV; Sheppard JA; Bode AP; Kelton JG 《Blood》1994,84(11):3691-3699
Heparin-induced thrombocytopenia is characterized by moderate thrombocytopenia and thrombotic complications, whereas quinine/quinidine-induced thrombocytopenia usually presents with severe thrombocytopenia and bleeding. Using flow cytometry and assays of procoagulant activity, we investigated whether sera from patients with these immune drug reactions could stimulate normal platelets to generate platelet-derived microparticles with procoagulant activity. Sera or purified IgG from patients with heparin-induced thrombocytopenia stimulated the formation of platelet-derived microparticles in a heparin-dependent fashion. Further studies showed that heparin-induced thrombocytopenia sera also produced a marked increase in procoagulant activity. In contrast, sera from patients with quinine- or quinidine-induced thrombocytopenia did not generate platelet-derived microparticles nor generate increased procoagulant activity. However, quinine/quinidine-induced thrombocytopenia sera produced a significant increase in the binding of IgG to platelets in a drug-dependent fashion, whereas sera from patients with heparin-induced thrombocytopenia demonstrated no drug-dependent binding of IgG to platelets. We also observed increased levels of circulating microparticles in patients with acute heparin-induced thrombocytopenia compared with control patients. Our observations indicate that the generation of procoagulant platelet-derived microparticles in vivo is a plausible explanation for the thrombotic complications observed in some patients with heparin-induced thrombocytopenia. 相似文献