全文获取类型
收费全文 | 3171篇 |
免费 | 189篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 69篇 |
妇产科学 | 77篇 |
基础医学 | 349篇 |
口腔科学 | 64篇 |
临床医学 | 222篇 |
内科学 | 617篇 |
皮肤病学 | 53篇 |
神经病学 | 82篇 |
特种医学 | 307篇 |
外科学 | 368篇 |
综合类 | 332篇 |
一般理论 | 3篇 |
预防医学 | 194篇 |
眼科学 | 300篇 |
药学 | 154篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 193篇 |
出版年
2023年 | 30篇 |
2022年 | 45篇 |
2021年 | 101篇 |
2020年 | 45篇 |
2019年 | 61篇 |
2018年 | 71篇 |
2017年 | 50篇 |
2016年 | 65篇 |
2015年 | 52篇 |
2014年 | 90篇 |
2013年 | 129篇 |
2012年 | 147篇 |
2011年 | 154篇 |
2010年 | 86篇 |
2009年 | 95篇 |
2008年 | 166篇 |
2007年 | 157篇 |
2006年 | 137篇 |
2005年 | 146篇 |
2004年 | 132篇 |
2003年 | 121篇 |
2002年 | 113篇 |
2001年 | 121篇 |
2000年 | 104篇 |
1999年 | 93篇 |
1998年 | 57篇 |
1997年 | 53篇 |
1996年 | 54篇 |
1995年 | 41篇 |
1994年 | 33篇 |
1993年 | 27篇 |
1992年 | 44篇 |
1991年 | 41篇 |
1990年 | 43篇 |
1989年 | 47篇 |
1988年 | 54篇 |
1987年 | 43篇 |
1986年 | 43篇 |
1985年 | 40篇 |
1984年 | 14篇 |
1983年 | 21篇 |
1982年 | 28篇 |
1981年 | 18篇 |
1980年 | 20篇 |
1979年 | 14篇 |
1978年 | 22篇 |
1977年 | 20篇 |
1976年 | 23篇 |
1975年 | 11篇 |
1972年 | 11篇 |
排序方式: 共有3396条查询结果,搜索用时 15 毫秒
1.
Xin Yi Wong Andrew Qi Jun Lim Qianyu Shen John Whay Kuang Chia Min Hoe Chew Wah Siew Tan 《Current medical research and opinion》2020,36(10):1677-1686
Abstract
Objective
Ras wild-type metastatic colorectal cancers (mCRC) may be treated with anti-vascular endothelial growth factor (VEGF) or anti-epidermal growth factor receptor (EGFR) agents. We aim to estimate patients’ preferences for mCRC treatment and relative importance of cost, efficacy improvement, avoidance of side effects and therapy convenience, and relative uptake between profiles that resemble Bevacizumab (anti-VEGF) and Cetuximab (anti-EGFR), two commonly prescribed mCRC targeted therapies. 相似文献2.
3.
4.
S Gunasti† SS Marakli† I Tuncer‡ N Ozpoyraz§ VL Aksungur† 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):811-817
BACKGROUND: We have seen several patients with itchy lichenified plaques located bilaterally on the elbows and/or knees and have named this condition 'psoriatic neurodermatitis' (PN). OBJECTIVE: The purpose of this study was to compare clinical and histopathological characteristics of these patients to those of patients with typical lichen simplex chronicus (LSC). METHODS: Nineteen patients with PN and 34 patients with typical LSC were included. Besides clinical dermatological evaluation, the prick test was carried out on 49 patients; the Phadiatop test on 40 patients; the patch test with European standard series on 47 patients; histopathological evaluation on 39 patients; and clinical psychiatric examination on 38 patients. RESULTS: Almost exclusively, PN was seen in females and was located on the extremities. It caused more plaques than typical LSC did. In PN, the plaques were smaller, sharper, more keratotic and less excoriated, and had fewer lichenoid papules around them. Itching was usually more severe in the evening, while resting and in a hot environment in typical LSC, but not in PN. In plaques of PN, microabscesses in the horny layer, hypogranulosis, regular acanthosis and thinning of the suprapapillary plates were more frequent, and hyperpigmentation in the basal layer was less. In patients with PN, depressive disorder was found more frequently; and generalized anxiety disorder or psychosomatic characteristics, less. There were no significant differences in the results of prick, Phadiatop and patch tests between patients with PN and those with typical LSC. CONCLUSION: In our opinion, it is most likely that the so-called PN is itchy psoriasis superimposed by LSC. 相似文献
5.
6.
Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in their transfusion response. All patients were receiving multiple platelet transfusions without achieving 1-hour corrected count increments (CCIs) > or = 7500. Eight patients had antibodies that reacted with platelets and were directed against HLA class I antigens, ABO antigens, and/or platelet-specific alloantigens. Plasma (500-2000 mL) from each patient was passed over a protein A silica gel column and then returned to the patient. Patients received from 1 to 14 treatments. A positive response to protein A therapy was defined as at least a doubling of the pretreatment platelet count and/or two successive 10- to 120-minute posttransfusion CCIs > or = 7500. Following plasma treatments, 6 of 10 patients responded with daily platelet counts that averaged 48 +/− 11 × 10(9) per L as compared with counts of 16 +/− 7 × 10(9) per L (p < 0.0005) before treatment. Posttransfusion CCI values determined in four of these patients averaged 2480 +/− 810 and 10,010 +/− 3540 (p < 0.005) before and after treatment, respectively. In contrast, among the four unresponsive patients, platelet counts averaged 10 +/− 9 and 13 +/− 10 × 10(9) per L (p = NS), respectively, while posttransfusion CCIs were 700 +/− 1410 and 1520 +/− 2460 (p = NS), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
7.
Lumbosacral nerve root avulsion 总被引:7,自引:0,他引:7
8.
9.
10.
Solitary bronchioloalveolar carcinoma: CT criteria 总被引:14,自引:0,他引:14
Kuhlman JE; Fishman EK; Kuhajda FP; Meziane MM; Khouri NF; Zerhouni EA; Siegelman SS 《Radiology》1988,167(2):379-382
The computed tomographic (CT) scans of 30 patients with solitary bronchioloalveolar carcinoma were reviewed. Common features at CT included the peripheral or subpleural location of a pulmonary mass (25 cases), pseudocavitation (18 cases), heterogeneous attenuation (17 cases), irregular margins forming a star pattern (22 cases), and pleural tags (21 cases). Using these CT criteria, four independent observers attempted to identify cases of bronchioloalveolar carcinoma from a larger sample of lung cancers and benign lesions by categorizing a series of test cases into four probability categories. Although the bronchioloalveolar carcinomas were correctly ranked in the two highest probability categories 75% of the time (in 45 of 60 cases), there was considerable overlap with other lung lesions, particularly with adenocarcinoma and large cell undifferentiated carcinoma. However, even though the typical features of bronchioloalveolar carcinoma are not invariable or highly specific, they are characteristic enough to suggest the diagnosis. 相似文献