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排序方式: 共有97条查询结果,搜索用时 15 毫秒
1.
LI-FERN HSU PIERRE JAÏS MÉLÈZE HOCINI PRASHANTHAN SANDERS MARTIN ROTTER YOSHIHIDE TAKAHASHI CHRISTOPHE SCAVÉE FREDERIC SACHER JACQUES CLÉMENTY MICHEL HAÏSSAGUERRE 《Pacing and clinical electrophysiology : PACE》2005,28(S1):S94-S98
The differentiation of pulmonary vein (PV) electrograms from atrial far-field signals during PV isolation (PVI) for atrial fibrillation (AF) may be difficult. In addition, owing to highly variable PV ostial sizes, current fixed-diameter circular PV mapping catheters may not yield optimal electrograms. We evaluated an expandable, circular 15–25 mm diameter, 20-pole mapping catheter for PV mapping during sustained AF in 25 patients. After selective PV angiography to define the ostial position and size, the catheter was introduced into each PV and withdrawn to the most stable proximal position, with optimal wall contact ensured by progressive loop expansion. At each PV ostium, electrograms recorded at high resolution (HR) were compared with those recorded at a resolution similar to that of a standard 10-pole Lasso catheter. After PVI performed during ongoing AF, the presence of residual far-field potentials (FFP) under both set-ups was compared. We mapped 97 PV, including 4 pairs with common ostia. In the HR recordings, the PV potentials had greater amplitude (0.5 ± 0.1 vs 0.3 ± 0.1 mV, P = 0.001) and fragmentation, whereas left atrial FFP were minimized. After successful isolation of all PV, FFP were observed in 33% of left superior and 28% of left inferior PV on the HR recordings, compared to 66% and 61%, respectively under normal resolution. Catheter stability and optimal wall contact, in combination with HR electrograms can optimize circumferential PV mapping during AF and improve the discrimination of FFP postablation. 相似文献
2.
PHILIPPE KIRSTETTER CHRISTOPHE PILETTE RICHARD MOREAU STEPHANE CAILMAIL VACLAV SAFKA THIERRY SOUPISON DIDIER LEBREC 《Journal of gastroenterology and hepatology》1996,11(3):230-235
The haemodynamic effects of nitrovasodilators and their mechanisms of action on portal hypertension remain unclear. The splanchnic and systemic haemodynamic response to the infusion of isosorbide dinitrate (100 μg/kg per min), a nitrovasodilator, was investigated in cirrhotic rats. The role of the conscious state in the haemodynamic response to isosorbide dinitrate was examined using rats that were anaesthetized with pentobarbitone. The role of sympathetic tone in the haemodynamic response to isosorbide dinitrate was examined using rats pretreated with the ganglion blocker hexamethonium. Isosorbide dinitrate had no haemodynamic effects in conscious, unblocked normal and cirrhotic rats. Isosorbide dinitrate had no haemodynamic effects in normal and cirrhotic rats treated with hexamethonium. In normal anaesthetized rats, isosorbide dinitrate significantly decreased systemic vascular resistance (414±25 vs 290±26 dyn.s/cm5 per 100 g). In cirrhotic anaesthetized rats, isosorbide dinitrate significantly decreased mean arterial pressure (98±6 vs 79±7 mmHg), systemic vascular resistance (318±30 vs 207±10 dyn.s/cm5 per 100 g), portal pressure (14.0±1.0 vs 11.3±0.9 mmHg) and portal territory vascular resistance (1362±163 vs 1031±182 dyn.s/cm5 per 100 g). In conclusion, this study shows that the portal hypotensive effects of isosorbide dinitrate depend upon the alterations of vascular tone by pentobarbitone. 相似文献
3.
ALAIN PATAT MICKEL CERCLE SUZANNE TROCHERIE GUYLAINE PEYTAVIN CHRISTOPHE POTIN HERV ALLAIN JEAN-MARC GANDON 《Human psychopharmacology》1996,11(4):321-335
Mefenorex is an indirect sympathomimetic amine which acts as an anorectic drug and is used in combination with low diet to treat excess weight. The central nervous system (CNS) effects of mefenorex were assessed in a randomized, double-blind, three-way cross-over, placebo-controlled study involving nine healthy young male volunteers. They received either a single oral dose of mefenorex 80 mg (twice the recommended dose) or d-amphetamine sulfate 18 mg or a placebo at 1-week intervals. CNS pharmacodynamic measurements consisted of subjective evaluation (visual analogue scales and the Addiction Research Centre inventory (ARCI)), EEG, psychomotor performance and attention (tracking, simple and choice reaction times, tapping, continuous performance task, DSST, body sway) and memory (working memory and recall of a word list). d-Amphetamine produced a typical psychostimulant EEG profile (significant decrease in slow delta waves and increase in fast beta activities), significantly increased amphetamine, benzedrine and morphine–benzedrine scores of ARCI and significantly decreased body sway compared to placebo and mefenorex. A trend in favour of a stimulant effect occurred for all other parameters (particularly speed of reaction) and no changes of memory were noticed. In contrast, mefenorex did not produce an amphetamine-like EEG profile, neither significantly changed ARCI scores nor significantly modified psychomotor and memory performance compared to the placebo, although it induced a decrease in body sway. In conclusion, the present results indicate that a single oral dose of mefenorex, at twice the recommended daily dose, does not possess amphetamine-like subjective and EEG stimulant effects or sensations of well-being, often encountered with drugs of abuse liability potential, in a healthy young population. 相似文献
4.
5.
RUKSHEN WEERASOORIYA M.B.B.S. † PIERRE JAIS M.D. NICOLAS LELLOUCHE M.D. MATTHEW WRIGHT M.D. SEBASTIEN KNECHT M.D. ISABELLE NAULT M.D. SHINSUKE MIYAZAKI M.D. FREDERIC SACHER M.D. MELEZE HOCINI M.D. CHRISTOPHE SCAVEE M.D. LAURENT MACLE M.D. MICHEL HAISSAGUERRE M.D. 《Journal of cardiovascular electrophysiology》2009,20(3):349-351
6.
Incidence and Prevention of Cardiac Tamponade Complicating Ablation for Atrial Fibrillation 总被引:4,自引:0,他引:4
LI-FERN HSU PIERRE JAÏS MÉLÈZE HOCINI PRASHANTHAN SANDERS CHRISTOPHE SCAVÉE FREDERIC SACHER YOSHIHIDE TAKAHASHI MARTIN ROTTER JEAN-LUC PASQUIE JACQUES CLÉMENTY MICHEL HAÏSSAGUERRE 《Pacing and clinical electrophysiology : PACE》2005,28(S1):S106-S109
Cardiac tamponade complicating catheter ablation of atrial fibrillation (AF) occurs in approximately 1% of pulmonary vein isolation (PVI), and up to 6% of linear ablation procedures. We reviewed 348 consecutive AF ablation (including repeat) procedures over 1 year, which all included PVI, with additional linear lesions at the mitral isthmus in 73%, and cavotricuspid isthmus (CTI) in 76%. An irrigated-tip ablation catheter was used, with power limited to 25–35 W for PVI and 45–60 W for linear lesions. Tamponade occurred in seven men and three women (2.9% of the population) during the creation of linear ablation lesions. Mechanical perforations occurred in two patients, and "popping" during radiofrequency (RF) energy delivery at the mitral isthmus in six, and at the CTI in two patients. Peak RF power was significantly higher in patients with than without tamponade (53 ± 4 W vs 48 ± 7 W; P = 0.02), and was greater than 48 W in all cases of "popping." In the following year, RF power for linear ablation was limited to ≤42 W. Among 398 procedures, tamponade occurred in four patients (1.0%; P = 0.047 vs first year), three from "popping" and one from mechanical trauma. Procedural success rate remained the same despite reduction of power. Risk of tamponade was highest during linear ablation, mainly associated with high energy delivery and "popping." Reducing the energy limited, though did not eliminate this complication. 相似文献
7.
Cardiac Resynchronization Therapy is an Important Advance in the Management of Congestive Heart Failure 总被引:1,自引:0,他引:1
CHRISTOPHE LECLERCQ M.D. Ph .D. J. CLAUDE DAUBERT M.D. 《Journal of cardiovascular electrophysiology》2003,14(S9):S27-S29
Cardiac resynchronization therapy (CRT) is an emerging therapy that improves symptoms and exercise tolerance in patients with advanced heart failure, left ventricular systolic dysfunction, and intraventricular conduction delay. By correcting the AV, interventricular, and intraventricular dyssynchrony induced by conduction disorders, controlled studies have shown that CRT improved functional status, decreased heart failure hospitalization rate, and might have a positive effect on left ventricular remodeling. Recent and preliminary data from the COMPANION trial suggest that CRT alone or in association with defibrillator capacity significantly reduced total mortality and hospitalization and that total mortality was significantly reduced only in the CRT plus implantable cardioverter defibrillator (ICD) group. Many questions remain unanswered, particularly the selection of responder patients. (J Cardiovasc Electrophysiol, Vol. 14, pp. S27-S29, September 2003, Suppl.) 相似文献
8.
Atrial Fibrillation in a Dual‐Chamber ICD Recipient with Activation of the Ventricular Intrinsic Preference Algorithm: What Is the Mechanism?
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9.
Changes in Implantation Patterns and Therapy Rates of Implantable Cardioverter Defibrillators over Time in Ischemic and Dilated Cardiomyopathy Patients
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10.