全文获取类型
收费全文 | 612篇 |
免费 | 39篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 25篇 |
妇产科学 | 6篇 |
基础医学 | 76篇 |
口腔科学 | 24篇 |
临床医学 | 79篇 |
内科学 | 111篇 |
皮肤病学 | 18篇 |
神经病学 | 24篇 |
特种医学 | 53篇 |
外科学 | 70篇 |
综合类 | 36篇 |
预防医学 | 44篇 |
眼科学 | 1篇 |
药学 | 56篇 |
中国医学 | 2篇 |
肿瘤学 | 53篇 |
出版年
2022年 | 6篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 9篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 16篇 |
2015年 | 7篇 |
2014年 | 12篇 |
2013年 | 22篇 |
2012年 | 19篇 |
2011年 | 23篇 |
2010年 | 27篇 |
2009年 | 18篇 |
2008年 | 32篇 |
2007年 | 27篇 |
2006年 | 24篇 |
2005年 | 28篇 |
2004年 | 17篇 |
2003年 | 27篇 |
2002年 | 25篇 |
2001年 | 19篇 |
2000年 | 14篇 |
1999年 | 16篇 |
1998年 | 25篇 |
1997年 | 35篇 |
1996年 | 21篇 |
1995年 | 15篇 |
1994年 | 15篇 |
1993年 | 6篇 |
1992年 | 11篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 9篇 |
1988年 | 14篇 |
1987年 | 9篇 |
1986年 | 13篇 |
1985年 | 8篇 |
1984年 | 13篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1969年 | 3篇 |
排序方式: 共有679条查询结果,搜索用时 593 毫秒
1.
2.
Marcel Bahro Earle Silber Paulette Box Trey Sunderland 《International journal of geriatric psychiatry》1995,10(10):871-874
For patients with Alzheimer's disease (AD), a recommendation to stop operating a motor vehicle can be a serious event complicated by a loss of self-esteem and personal dignity. Patients are often reluctant to give up an activity so essential, both practically and symbolically, to independent living. We describe here a patient with moderately progressed AD who lacked insight of his need to cease driving. Through an integrative treatment approach, combining behavioral and psychodynamic modalities, we helped him to formulate effective ways of coping with his loss of access to independent transportation. We favor a psychotherapeutic strategy that combines behavioral and managerial measures with dynamic patient interaction, thereby developing the patient's insight of the need to give up driving while fostering his sense of autonomy. 相似文献
3.
4.
反坦克武器击中坦克时舱室内有害气体测试方法的探讨 总被引:1,自引:1,他引:0
为探讨在模拟实验条件下,坦克受到反我武器攻击后舱室内有害气体的取样方法和分析方法,用3种武器发射3种弹药攻击坦克,在远距离控制取样设备,取样后在实验室进行坦克舱室内有害气体浓度分析,结果取样成功,坦克被击中后,一氧化碳气体含量有明显的增高,氮氧化物、二氧化硫增高幅度不大,氧含量无明显变化,说明对坦克舱室进行远距离现场控制气体采样是可行的;坦克的受反坦克武器打击后,除弹片和冲击波等致伤因素外,还会造成坦克内乘员一氧化碳中毒。 相似文献
5.
6.
P. M. Patel C. L. Flemming S. J. Russell I. A. McKay K. A. MacLennan G. M. Box S. A. Eccles M. K. Collins 《British journal of cancer》1993,68(2):295-302
Engineering of a variety of rodent tumour cells to secrete either interleukin 2 (IL-2), or interleukin 4 (IL-4), has been demonstrated to reduce their tumorigenicity. However the mechanisms of action of secreted IL-2 and IL-4 have not been compared in a single rodent tumour. Here we demonstrate that the weakly immunogenic murine fibrosarcoma FS29 had reduced growth rate and in some cases was rejected by syngeneic animals, when modified to secrete either IL-2 or IL-4, but not IL-5. Immunohistochemical analysis of tumour nodules undergoing regression showed stimulation of a largely lymphocytic infiltrate by IL-2 and a macrophage and granulocyte infiltrate, with a small number of lymphocytes by IL-4. Indeed, secretion of low levels of IL-2 and IL-4 in combination resulted in optimal rejection, suggesting that the two cytokines might mobilise different and complementary effector cell mechanisms. Both IL-2 and IL-4-secreting cells failed to induce the rejection of admixed, unmodified FS29 cells. The loss of cytokine secreting cells from such admixtures occurred more rapidly for IL-2-secreting cells. Injection of IL-4-secreting, but not IL-2-secreting FS29 cells could protect mice from a delayed challenge with unmodified FS29 cells. These data suggest that IL-4 secretion stimulates the better long-term host anti-tumour response. 相似文献
7.
8.
doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH) 总被引:12,自引:0,他引:12
des Portes V; Francis F; Pinard JM; Desguerre I; Moutard ML; Snoeck I; Meiners LC; Capron F; Cusmai R; Ricci S; Motte J; Echenne B; Ponsot G; Dulac O; Chelly J; Beldjord C 《Human molecular genetics》1998,7(7):1063-1070
Subcortical laminar heterotopia (SCLH), or 'double cortex', is a cortical
dysgenesis disorder associated with a defect in neuronal migration.
Clinical manifestations are epilepsy and mental retardation. This disorder,
which mainly affects females, can be inherited in a single pedigree with
lissencephaly, a more severe disease which affects the male individuals.
This clinical entity has been described as X- SCLH/LIS syndrome. Recently
we have demonstrated that the doublecortin gene, which is localized on the
X chromosome, is implicated in this disorder. We have now performed a
systematic mutation analysis of doublecortin in 11 unrelated females with
SCLH (one familial and 10 sporadic cases) and have identified mutations in
10/11 cases. The sequence differences include nonsense, splice site and
missense mutations and these were found throughout the gene. These results
provide strong evidence that loss of function of doublecortin is the major
cause of SCLH. The absence of phenotype-genotype correlations suggests that
X-inactivation patterns of neuronal precursor cells are likely to
contribute to the variable clinical severity of this disorder in females.
相似文献
9.
10.
Stein TP; Oram-Smith JC; Leskiw MJ; Wallace HW; Long LC; Leonard JM 《The American journal of physiology》1976,230(5):1321-1325