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Dietary polyamines promote the growth of azoxymethane-induced aberrant crypt foci in rat colon 总被引:1,自引:1,他引:1
We have examined whether dietary polyamines influence the formation and
initial growth of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in
rat colon. Effects of a combination of dietary polyamines at three dose
levels (putrescine: 50, 280, 740 nmol/g; spermidine: 10, 261, 763 nmol/g;
spermine: 1, 31, 91 nmol/g) in the polyamine-poor AIN-76A diet were studied
in animals in two different experimental situations: animals treated with
AOM alone and animals treated with AOM + difluoromethylornithine (DFMO), a
specific inhibitor of endogenous polyamine synthesis. In both experimental
situations, dietary polyamines enhanced the growth of ACF, expressed as the
number of large ACF (foci with three or more aberrant crypts, ACF > or =
3), whereas the formation of ACF, expressed as the number of ACF, was
apparently not altered. In animals treated with AOM alone, maximal growth
enhancing effect on ACF was nearly obtained with the median level of
dietary polyamine. In rats fed a low polyamine diet, basic AIN-76A, DFMO
reduced the growth of AOM-induced ACF by 83%. This inhibitory effect of
DFMO was counteracted by dietary polyamines in a dose- dependent manner,
and it was abolished at the highest level of polyamines. In conclusion, it
was demonstrated that dietary polyamines are able to enhance the growth of
AOM-induced ACF. Further, dietary polyamines reversed the DFMO-caused
inhibition of ACF growth, probably by compensating for the DFMO-reduced
endogenous polyamine synthesis.
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I. VANČOVÁ V. HAJNICKÁ M. SLOVÁK P. KOCÁKOVÁ G. C. PAESEN P. A. NUTTALL 《Parasite immunology》2010,32(6):460-463
Ticks exploit many evasion mechanisms to circumvent the immune control of their hosts including subversion of the communication language between cells of the immune system provided by chemokines and other cytokines. One subversive molecule secreted in the saliva of Rhipicephalus sanguineus is Evasin‐3, a structurally unique 7 kDa protein that selectively binds the neutrophil chemoattractants, CXCL8 and (with lower affinity) CXCL1. We compared anti‐human CXCL8 and anti‐mouse CXCL1/KC activities in salivary gland extracts prepared from adult Amblyomma variegatum, Rhipicephalus appendiculatus and Dermacentor reticulatus ticks during blood‐feeding. Both anti‐CXCL8 activity and anti‐CXCL1 activity were detected in all species and in both adult females and males, with consistently higher activity levels against CXCL8. These results suggest that Evasin‐3‐like activity is common amongst metastriate ixodid tick species, and provide further evidence of the importance to ticks in controlling neutrophils during blood‐feeding. As such, Evasin‐3 offers a new target for anti‐tick vaccine development. 相似文献
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目的了解β地中海贫血(地贫)CD41-42(-TCTT)杂合子(β41-42杂合子)复合缺失型α地贫双重杂合子在本地区β41-42杂合子个体中的检出情况及其临床血液学表现.方法分别采用单管多重PCR与反向点杂交法检测缺失型α地贫与β地贫基因,常规进行血细胞分析及其它地贫筛查试验.结果 144例β41-42杂合子有8例同时复合缺失型α地贫杂合子,其中7例(4.9%)携带有α地贫1基因(αα/--SEA),1例(0.69%)携带有缺失型HbH基因(-α3.7/--SEA).7例复合α地贫1患者的MCV均都高于另外136例单纯的β41-42杂合子的MCV平均值(63.53fl); 而对携带有HbH基因的样本进行pH8.6与6.5的血红蛋白电泳时都无法找到HbH区带.结论诊断β41-42杂合子复合α地贫双重杂合子的患者时,如只依赖其临床表现和常规的实验室检查结果作为筛查诊断的指标,容易会出现有病患的α或β地贫基因漏诊的情况. 相似文献
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Berdiugina OV Berdiugin KA 《Zhurnal voprosy ne?rokhirurgii imeni N. N. Burdenko》2007,(4):16-20; discussion 20
Adequacy of diagnostic actions, choice, on their basis, of a treatment for patients with vertebral fractures and spinal cord injury, improvement of the results of surgical treatment are anactual problem of modern traumatology and neurosurgery. The purpose of the study was to define the role of immunological monitoring in the evaluation of patients' condition in the presence of spinal damage. Blood was tested in 111 patients during two-stage surgical treatment for spinal damages: 1) osteosynthesis by an external fixation device and 2) anterior spinal fusion. The results of general clinical blood checks, lymphocytic phenotyping, determination of neutrophilic functional and metabolic activity, the levels of circulating immune complexes and immunoglobulins, the concentrations of cytokines (IL-1alpha, IL-1beta, IL-1ra, IL-8, tumor necrosis factor-alpha) and acute-phase proteins were estimated before surgery and in different periods up to 6 months inclusive. Statistical studies were conducted using the STATISTICA program. Examination of three groups of patients (two of which had postoperative complications, the other was a control group) has ascertained that immunological monitoring in the treatment of spinal injure may be used to predict postoperative complications, such as delayed consolidation and impaired formation of a bone block in the vertebral segment, be made in different management periods (before surgery and on follow-up days 2 or 10), and include prognostic tests, by taking into account the capacities of a laboratory service. 相似文献
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There was noted a reaction of the immune system to big-joint replacements, which developed both as a stereotype acute-phase response to the surgical intervention and a moderate immunosuppression, and as a response to the functioning of the implant (beginning from month 6 after surgery), when a mild phagocytes' activity and moderate changes in the acute-phase proteins were registered. Later, the monocyte-lymphocyte reaction of blood involving a higher production of osteoresorptive IL-1 and TNF were observed during the shaping resorption of osseous tissue. Complications can be prognosticated on the basis of the below: contents of leukocytes' main populations; activity of cytoplasm cation proteins; and concentration of the main classes of immunoglobulins and of IL-1. 相似文献
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Index
SOFFCO, Montpellier 31 mai–2 juin 2012 Index des auteurs 相似文献10.