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Khani Tahereh Alamzadeh Zahra Sarikhani Abolfazl Mousavi Mahdie Mirrahimi Mehri Tabei Mousa Irajirad Rasoul Abed Ziaeddin Beik Jaber 《Lasers in medical science》2022,37(5):2387-2395
Lasers in Medical Science - The combination of multiple therapeutic and diagnostic functions is fast becoming a key feature in the area of clinical oncology. The advent of nanotechnology promises... 相似文献
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Steroid withdrawal and donor-specific hyporeactivity after cadaveric renal allotransplantation on maintenance triple therapy 总被引:1,自引:1,他引:0
Background. Even in low doses, long-term steroid
immunosuppression is known to cause serious complications. However, the
safety of steroid withdrawal has not been proven in randomized clinical
trials. This study examines donor-specific hyporesponsive transplant
recipients before and after steroid withdrawal, to see if reduction in
immunosuppression was associated with consistent changes in antidonor
immunological reactivity. Methods. Using limiting
dilution assays, the circulating precursor frequency of donor and
third-party-reactive helper T lymphocytes (HTLpf) were determined in 21
consecutive cadaveric renal allograft recipients on standard triple
therapy, before (pre-tx) and at different time points after transplantation
(post-tx). Patients were selected for steroid withdrawal by clinical
criteria (stable graft function and no or only one very mild rejection
episode). Results. Of 21 patients studied, steroids
were successfully withdrawn in nine (steroid withdrawn group, SWG) for at
least 187 days (mean: 380±168.5), and were not withdrawn in 12
patients (steroid continued group, SCG). In the SWG seven of nine patients
developed at least fivefold reduction of post-tx donor-reactive HTLpf
(range 5-17), relative to pre-tx, as compared to two of twelve patients in
the SCG, P=0.01. In both groups, the third-party-reactive HTLpf in most of
these patients remained largely unchanged throughout the study period. In
the SWG, no significant difference of serum creatinine level was found
before and at 6 months after steroid withdrawal (mean: 138±24
versus 132±40, P=0.45).
Conclusions. Patients who developed donor-specific
hyporeactivity as evidenced by low donor-reactive HTLpf had stable graft
function and stable HTLpf levels after complete steroid withdrawal. 相似文献
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Ohne Zusammenfassung 相似文献
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H Schmechel P Beiküfner G Panzram 《Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete》1984,39(18):453-457
In 243 diabetics of different duration of the disease the prognostic value of an initial estimation of plasma fibrinogen for life expectancy and development of macroangiopathy was controlled over a period of ten years. Diabetics with a cardiovascular cause of death showed at the beginning with 3.68 in contrast to 3.24 g/l weakly significantly higher fibrinogen values than the surviving patients. In analogy to this in the surviving patients the diabetics with a meanwhile appearing myocardial infarction, chronic ischaemic heart disease or manifest disturbances of the peripheral blood supply differed by higher fibrinogen concentrations from test persons without manifest macroangiopathy. There was a close correlation between plasma fibrinogen level and development of hypertension. The increase of plasma fibrinogen is apparently associated with the atherogenesis without rendering a secure prognosis in the individual case on account of a critical limiting value. 相似文献
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H. Ghaffari J. Beik A. Talebi S. R. Mahdavi H. Abdollahi 《Clinical & translational oncology》2018,20(12):1502-1521
Cancer stem cells (CSCs) have been identified as the main center of tumor therapeutic resistance. They are highly resistant against current cancer therapy approaches particularly radiation therapy (RT). Recently, a wide spectrum of physical methods has been proposed to treat CSCs, including high energetic particles, hyperthermia (HT), nanoparticles (NPs) and combination of these approaches. In this review article, the importance and benefits of the physical CSCs therapy methods such as nanomaterial-based heat treatments and particle therapy will be highlighted. 相似文献
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Effects of unilatral‐ and bilateral inhibition of rostral ventral tegmental area and central nucleus of amygdala on morphine‐induced place conditioning in male Wistar rat
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Zahra Mohammadian Hedayat Sahraei Gholam Hossein Meftahi Hengameh Ali‐Beik 《Clinical and experimental pharmacology & physiology》2017,44(3):403-412
The rostral ventral tegmental area (VTAR) and central nucleus of amygdala (CeA) are considered the main regions for induction of psychological dependence on abused drugs, such as morphine. The main aim of this study was to investigate the transient inhibition of each right and left side as well as both sides of the VTAR and the CeA by lidocaine (2%) on morphine reward properties using the conditioned place preference (CPP) method. Male Wistar rats (250±20 g) 7 days after recovery from surgery and cannulation were conditioned to morphine (7.5 mg/kg) in CPP apparatus. Five minutes before morphine injection in conditioning phase, lidocaine was administered either uni‐ or bilaterally into the VTAR (0.25 μL/site) or CeA (0.5 μL/site). The results revealed that lidocaine administration into the left side, but not the right side of the VTAR and the CeA reduced morphine CPP significantly. The reduction was potentiated when lidocaine was injected into both sides of the VTAR and the CeA. The number of compartment crossings was reduced when lidocaine was injected into both sides of the VTAR and the CeA as well as the left side. Rearing was reduced when lidocaine was injected into the right, but not the left side of the VTAR. Sniffing and rearing increased when animals received lidocaine in the right side and reduced in the group that received lidocaine in the left side of the CeA. It was concluded that the right and the left side of VTAR and the CeA play different roles in morphine‐induced activity and reward. 相似文献
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