全文获取类型
收费全文 | 1209篇 |
免费 | 142篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 72篇 |
妇产科学 | 13篇 |
基础医学 | 156篇 |
口腔科学 | 56篇 |
临床医学 | 167篇 |
内科学 | 233篇 |
皮肤病学 | 14篇 |
神经病学 | 78篇 |
特种医学 | 283篇 |
外科学 | 118篇 |
综合类 | 20篇 |
预防医学 | 55篇 |
眼科学 | 7篇 |
药学 | 53篇 |
肿瘤学 | 52篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 11篇 |
2019年 | 12篇 |
2018年 | 25篇 |
2017年 | 12篇 |
2016年 | 14篇 |
2015年 | 22篇 |
2014年 | 28篇 |
2013年 | 23篇 |
2012年 | 33篇 |
2011年 | 27篇 |
2010年 | 44篇 |
2009年 | 30篇 |
2008年 | 28篇 |
2007年 | 44篇 |
2006年 | 42篇 |
2005年 | 30篇 |
2004年 | 28篇 |
2003年 | 38篇 |
2002年 | 23篇 |
2001年 | 27篇 |
2000年 | 21篇 |
1999年 | 25篇 |
1998年 | 65篇 |
1997年 | 74篇 |
1996年 | 82篇 |
1995年 | 51篇 |
1994年 | 40篇 |
1993年 | 47篇 |
1992年 | 23篇 |
1991年 | 20篇 |
1990年 | 33篇 |
1989年 | 47篇 |
1988年 | 44篇 |
1987年 | 40篇 |
1986年 | 36篇 |
1985年 | 40篇 |
1984年 | 11篇 |
1983年 | 15篇 |
1982年 | 17篇 |
1981年 | 11篇 |
1980年 | 13篇 |
1979年 | 4篇 |
1978年 | 6篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 8篇 |
1973年 | 6篇 |
1969年 | 3篇 |
排序方式: 共有1379条查询结果,搜索用时 15 毫秒
1.
Isolated patellofemoral arthritis is an increasingly recognized entity, and is usually associated with previous patellofemoral dysplasia or instability. Patellofemoral arthroplasty (PFA) has evolved significantly in recent years, both in terms of implant design and importantly in the understanding of appropriate patient selection. This review outlines the indications and investigations for PFA, provides a brief history of the development of contemporary implants, and presents the clinical outcomes for the prostheses most commonly used in the UK. In addition, it provides a detailed surgical technique for implantation of an onlay implant, with tips on how to optimize patellofemoral biomechanics and thus achieve a consistently good outcome. 相似文献
2.
3.
Sonoelasticity imaging of prostate cancer: in vitro results 总被引:2,自引:0,他引:2
4.
5.
6.
7.
Michael F. Maguire Janet A. Latter Ravi Mahajan F. David Beggs John P. Duffy 《European journal of cardio-thoracic surgery》2006,29(6):873-879
Objective: Our aim was to investigate the prevalence of intra-operative nerve damage and its association with chronic pain. Methods: Our prospective study of 33 patients used nerve conduction studies to assess intercostal nerve function during elective thoracic surgical procedures. We used two methods to study nerve conduction: pre-operative magnetic stimulation (in 10 patients) and intra-operative nerve conduction studies (in all patients) We correlated these findings with specific intra-operative parameters, pain and psychological questionnaires pre-op and 3 month post-op and altered cutaneous sensation. Results: Magstim (magnetic stimulation) assessments were not reliable and were therefore abandoned. Intraoperative intercostal nerve studies revealed two distinct patterns of nerve injury and also that nerve injury was less in those cases where a rib was not resected. However, intercostal nerve damage detected at the time of operation is not associated with chronic pain or altered cutaneous sensation at 3 months post-op. Conclusions: The study findings suggest that either the amount of intra-operative intercostal nerve damage is not indicative of long-term nerve damage or that there is a more significant cause for chronic pain other than intercostal nerve injury. 相似文献
8.
Edward Black Jason Niamat Srikanth Boddu Antonio Martin-Ucar John P Duffy William Ellis Morgan Francis David Beggs 《European journal of cardio-thoracic surgery》2006,29(2):244-247
OBJECTIVE: There are limited and conflicting data available concerning the incidence of inadvertent splenectomy and its impact on the outcome in patients who have undergone oesophagectomy. The aim of this study is to identify the factors associated with a likelihood of inadvertent splenectomy and its influence on early and long-term outcome in patients having oesophagectomy for oesophageal carcinoma. METHODS: A consecutive series of 738 oesophagectomies performed between 1991 and 2004 was analysed. In our practice, the spleen was removed only if damaged intraoperatively. Routine chemo- and immunoprophylaxis would subsequently be used. Multivariate analysis with logistic and Cox models determined significant variables. RESULTS: Of the 738 oesophagectomies, 48 (6.5%) had splenectomy. Neoadjuvant chemotherapy was administered to a minority of patients; none subsequently had splenectomy. There were significant differences between types of operation (Ivor-Lewis 18 (9.0%), left thoracolaparotomy 14 (9.9%) and left thoracophrenotomy 15 (3.9%), p=0.01). Splenectomy was more common with advanced N stage disease (OR=0.44 [0.20-0.95]; p=0.04). Splenectomy resulted in more blood transfusions (median, 2 units vs 0 units; p=0.03) more anastomotic leaks (7 [14.6%] vs 42 [6.1%]; p=0.02) but not an increase in pulmonary complications (p=0.64) or in-hospital mortality (1 [4.6%] vs 37 [5.4%]; p=0.30). Splenectomy did not significantly affect median survival (551 [332-770] days vs 627 [554-700] days; p=0.63). CONCLUSION: Although inadvertent splenectomy increased the morbidity of oesophagectomy, it did not impair survival. Type of operation and advanced N stage are important risks for splenectomy. Though best avoided, most of the consequences of splenectomy can be managed. An unexpected relationship between splenectomy and anastomotic leaks needs further investigation. 相似文献
9.
10.
Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in their transfusion response. All patients were receiving multiple platelet transfusions without achieving 1-hour corrected count increments (CCIs) > or = 7500. Eight patients had antibodies that reacted with platelets and were directed against HLA class I antigens, ABO antigens, and/or platelet-specific alloantigens. Plasma (500-2000 mL) from each patient was passed over a protein A silica gel column and then returned to the patient. Patients received from 1 to 14 treatments. A positive response to protein A therapy was defined as at least a doubling of the pretreatment platelet count and/or two successive 10- to 120-minute posttransfusion CCIs > or = 7500. Following plasma treatments, 6 of 10 patients responded with daily platelet counts that averaged 48 +/− 11 × 10(9) per L as compared with counts of 16 +/− 7 × 10(9) per L (p < 0.0005) before treatment. Posttransfusion CCI values determined in four of these patients averaged 2480 +/− 810 and 10,010 +/− 3540 (p < 0.005) before and after treatment, respectively. In contrast, among the four unresponsive patients, platelet counts averaged 10 +/− 9 and 13 +/− 10 × 10(9) per L (p = NS), respectively, while posttransfusion CCIs were 700 +/− 1410 and 1520 +/− 2460 (p = NS), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献