全文获取类型
收费全文 | 2986篇 |
免费 | 227篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 94篇 |
妇产科学 | 160篇 |
基础医学 | 350篇 |
口腔科学 | 59篇 |
临床医学 | 226篇 |
内科学 | 658篇 |
皮肤病学 | 73篇 |
神经病学 | 308篇 |
特种医学 | 81篇 |
外科学 | 344篇 |
综合类 | 71篇 |
一般理论 | 3篇 |
预防医学 | 234篇 |
眼科学 | 51篇 |
药学 | 249篇 |
中国医学 | 18篇 |
肿瘤学 | 213篇 |
出版年
2023年 | 18篇 |
2022年 | 23篇 |
2021年 | 60篇 |
2020年 | 45篇 |
2019年 | 40篇 |
2018年 | 40篇 |
2017年 | 41篇 |
2016年 | 40篇 |
2015年 | 45篇 |
2014年 | 71篇 |
2013年 | 129篇 |
2012年 | 208篇 |
2011年 | 209篇 |
2010年 | 106篇 |
2009年 | 99篇 |
2008年 | 151篇 |
2007年 | 176篇 |
2006年 | 196篇 |
2005年 | 190篇 |
2004年 | 193篇 |
2003年 | 164篇 |
2002年 | 158篇 |
2001年 | 56篇 |
2000年 | 64篇 |
1999年 | 66篇 |
1998年 | 31篇 |
1997年 | 20篇 |
1996年 | 28篇 |
1995年 | 33篇 |
1994年 | 28篇 |
1993年 | 22篇 |
1992年 | 29篇 |
1991年 | 15篇 |
1990年 | 20篇 |
1989年 | 19篇 |
1988年 | 31篇 |
1987年 | 24篇 |
1986年 | 24篇 |
1985年 | 28篇 |
1984年 | 25篇 |
1983年 | 18篇 |
1982年 | 15篇 |
1981年 | 22篇 |
1980年 | 12篇 |
1979年 | 16篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1976年 | 22篇 |
1974年 | 11篇 |
1966年 | 9篇 |
排序方式: 共有3223条查询结果,搜索用时 15 毫秒
1.
Basil D'Souza George Dimitroulis 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(4):e59-e61
This is a case study of a patient with recurrent synovial chondromatosis. It shows some relevant images. It also provides possibilities for why this patient may have had a recurrence and how this was managed. 相似文献
2.
Dozent Dr. Walther Gros Dr. Basil Roussoulis 《Journal of molecular medicine (Berlin, Germany)》1940,19(35):885-887
Zusammenfassung Die von uns angegebene Flockungsprobe im Serum mit Hayemscher Lösung zur Diagnose der atrophischen Lebercirrhose und zur einfachen Erkennung der meisten Takata-positiven und Takata-negativen Seren eignet sich auch zur Untersuchung von Ascites bezüglich seiner Genese. Auf Zusatz von Hayemscher Lösung zeigt der Ascites bei Lebercirrhose ein wesentlich anderes Verhalten als der Ascites bei Carcinom, Nephrose oder Herzinsuffizienz. Die einfache und rasch ausführbare Untersuchung des frischen Ascites mit Hayemscher Losung gestattet daher einen Ascites bei Lebercirrhose von solchen anderer Genese in kurzer Zeit zu differenzieren. 相似文献
3.
4.
5.
Basil A. Stoll Lars J. Vatten Stener Kvinnsland 《Acta oncologica (Stockholm, Sweden)》1994,33(2):171-176
Earlier onset of menarche and tallness in adult women are mainly confirmed as risk markers for breast cancer. Recent disparate case-control studies have reported abdominal-type obesity and higher circulating levels of insulin, testosterone and insulin-like growth factor 1, to be further risk markers for breast cancer. There is evidence that abdominal-type obesity is recognisable in girls even before puberty, and disparate studies have shown it to be correlated with earlier onset of menarche, insulin resistance leading to hyperinsulinaemia, and an abnormal sex steroid profile. The implications are that earlier onset of puberty in a subset of girls can lead to more prolonged exposure of developing breast tissue to an abnormal sex steroid profile and also to a higher circulating level of insulin. It is postulated that these metabolic/endocrine concomitants of abdominal-type obesity could play a role in promoting mammary carcinogenesis at a young age, particularly if genetic predisposition is present. 相似文献
6.
Basil Lee 《Journal of the Royal Society of Medicine》1994,87(8):485-486
7.
8.
Vig PJ Lopez ME Wei J D'Souza DR Subramony S Henegar J Fratkin JD 《Journal of neurological sciences (Turkish)》2006,23(3):166-174
Spinocerebellar ataxia-1 (SCA1) is caused by the expansion of a polyglutamine repeat within the disease protein, ataxin-1. The overexpression of mutant ataxin-1 in SCA1 transgenic mice results in the formation of cytoplasmic vacuoles in Purkinje neurons (PKN) of the cerebellum. PKN are closely associated with neighboring Bergmann glia. To elucidate the role of Bergmann glia in SCA1 pathogenesis, cerebellar tissue from 7 days to 6 wks old SCA1 transgenic and wildtype mice were used. We observed that Bergmann glial S100B protein is localized to the cytoplasmic vacuoles in SCA1 PKN. These S100B positive cytoplasmic vacuoles began appearing much before the onset of behavioral abnormalities, and were negative for other glial and PKN marker proteins. Electron micrographs revealed that vacuoles have a double membrane. In the vacuoles, S100B colocalized with receptors of advanced glycation end-products (RAGE), and S100B co-immunoprecipated with cerebellar RAGE. In SCA1 PKN cultures, exogenous S100B protein interacted with the PKN membranes and was internalized. These data suggest that glial S100B though extrinsic to PKN is sequestered into cytoplasmic vacuoles in SCA1 mice at early postnatal ages. Further, S100B may be binding to RAGE on Purkinje cell membranes before these membranes are internalized. 相似文献
9.
Models are intellectual constructs that pattern selected relationships among the elements of one system to correspond in some way to elements of a second system. In pharmacokinetics, physiological models provide a clearly articulated, rational, explanatory basis for the integration of empirical data; they do this by partitioning the biological system into relevant components (tissues, organs, etc.) and linking them together through the circulatory system. Unlike conventional mammillary compartment models, there is a clear correspondence between model system elements and physiological entities. By virtue of their high degree of physical and biochemical relevance, these models can help provide deep insight into structure, function and mechanism. Pharmacokinetic (and potentially pharmacodynamic) response-time relationships can thus be understood in terms of interconnections and behavior of constituent subsystems. At their worst, these models provide stale or infertile views of reality and thus frustrate and alienate us with the triviality of their insights. At their best, they allow us to understand the accumulation of thought in pharmacokinetics and pharmacodynamics, and help with the integration of data and improvement of experimental design. 相似文献
10.
Glycine site of the excitatory amino acid N-methyl-D-aspartate receptor in neonatal and adult brain.
The N-methyl-D-aspartate (NMDA) receptor complex in brain is a glutamate receptor subtype with several recognition sites including a glycine site that is able to modulate and activate allosterically the receptor. This receptor may be important in the regulation of developmental synaptic plasticity. The release of glutamate and consequent overstimulation of NMDA receptors that follows hypoxia-ischaemia leads to brain damage. Brain tissue obtained at necropsy was studied in a total of 16 term infants aged less than 1 week to 22 weeks and in four adults aged from 66 to 84 years. Glycine sites were determined in brain sections by the binding of the selective ligand [3H]5,7-dichloro-kynurenic acid and measured by autoradiography. In infant brains the amount of binding to the glycine site was higher in temporal cortex and hippocampus than in basal ganglia and was also higher than in comparable areas of adult brain. The amount of glycine site binding in infant cortex increased with postnatal age. The data suggest that infant brain acquires a relatively high density of NMDA receptors in temporal lobe due to postnatal proliferation of glutamatergic synapses. These findings have therapeutic implications as drugs that reduce NMDA receptor function by blocking the glycine modulatory site would be pertinent to preventing brain damage after hypoxia-ischaemia. 相似文献