全文获取类型
收费全文 | 5152篇 |
免费 | 232篇 |
国内免费 | 121篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 162篇 |
妇产科学 | 76篇 |
基础医学 | 541篇 |
口腔科学 | 61篇 |
临床医学 | 424篇 |
内科学 | 1436篇 |
皮肤病学 | 109篇 |
神经病学 | 405篇 |
特种医学 | 487篇 |
外国民族医学 | 1篇 |
外科学 | 575篇 |
综合类 | 45篇 |
预防医学 | 378篇 |
眼科学 | 66篇 |
药学 | 331篇 |
中国医学 | 3篇 |
肿瘤学 | 368篇 |
出版年
2023年 | 18篇 |
2022年 | 6篇 |
2021年 | 31篇 |
2020年 | 20篇 |
2019年 | 31篇 |
2018年 | 54篇 |
2017年 | 23篇 |
2016年 | 41篇 |
2015年 | 51篇 |
2014年 | 39篇 |
2013年 | 76篇 |
2012年 | 372篇 |
2011年 | 396篇 |
2010年 | 137篇 |
2009年 | 119篇 |
2008年 | 345篇 |
2007年 | 409篇 |
2006年 | 366篇 |
2005年 | 392篇 |
2004年 | 335篇 |
2003年 | 302篇 |
2002年 | 294篇 |
2001年 | 207篇 |
2000年 | 288篇 |
1999年 | 151篇 |
1998年 | 109篇 |
1997年 | 98篇 |
1996年 | 108篇 |
1995年 | 71篇 |
1994年 | 64篇 |
1993年 | 67篇 |
1992年 | 14篇 |
1991年 | 31篇 |
1990年 | 26篇 |
1989年 | 49篇 |
1988年 | 40篇 |
1987年 | 57篇 |
1986年 | 29篇 |
1985年 | 45篇 |
1984年 | 19篇 |
1983年 | 16篇 |
1982年 | 25篇 |
1981年 | 20篇 |
1980年 | 30篇 |
1979年 | 9篇 |
1978年 | 11篇 |
1977年 | 16篇 |
1976年 | 26篇 |
1975年 | 15篇 |
1970年 | 3篇 |
排序方式: 共有5505条查询结果,搜索用时 15 毫秒
1.
2.
Lucia Nogovà MD Volker Diehl MD Andreas Engert MD 《Current hematologic malignancy reports》2006,1(1):60-65
Lymphocyte-predominant Hodgkin’s lymphoma (LPHL) differs in histologic and clinical presentation from classical Hodgkin’s
lymphoma (cHL). Treatment of LPHL patients using standard Hodgkin’s lymphoma protocols leads to complete remission in more
than 95% of patients. Survival and freedom from treatment failure are substantially worse in advanced-stage patients than
for early-stage patients. Thus, patients in advanced stages and those in early stages with unfavorable risk factors should
be treated similar to those with cHL. In contrast, patients with early-stage LPHL without risk factors might be sufficiently
treated with reduced-intensity programs having less severe adverse effects. As a result, treatment of early LPHL is rather
heterogeneous, including radiotherapy using extended-fleld technique, involved-fleld radiotherapy (IF-RT), combined-modality
treatment, and, more recently, monoclonal antibodies. Watch-and-wait strategy plays an important role in pediatric oncology,
to avoid adverse effects associated with therapy. IF-RT seems to be emerging as a treatment of choice for patients with stage
IA LPHL; most larger study groups, such as the German Hodgkin Study Group and the European Organisation for Research and Treatment
of Cancer, have adopted IF-RT as the treatment of choice for these patients. 相似文献
3.
Summary— To investigate if the functional alterations observed in resistance arteries of spontaneously hypertensive rats (SHRs) were also present at the coronary level, in vitro experiments were performed in mesenteric resistance arteries (MRA) and in right (RIC) and left interventricular coronary (LIC) arteries taken from 15–25-week-old SHR and age-matched Wistar Kyoto rats WKYs. Using a passive extension protocol, internal diameters corresponding to 100 mmHg intraluminal pressure (D100) were determined and vessels were set up to a normalized internal diameter (0.9 D100). SHR mesenteric resistance arteries had a significantly smaller diameter compared to WKY arteries, whereas both types of SHR coronary arteries had a greater diameter compared to those of WKY rats. In arteries in the absence of contracting agonist, nitro-L-arginine (NOLA, 100 μM) induced a progressive rise in basal tone, which could be reversed by subsequent addition of L-arginine (100 μM) but not D-arginine (100 μM). When expressed as percent of maximal contractions induced by agonists (noradrenaline, NA [10 μM] in MRA; serotonin, 5-HT [10 μM], in RIC and LIC), these contractions were significantly stronger in WKY compared to SHR coronary and mesenteric resistance arteries. In NA-precontracted MRA and 5HT-precontracted coronary arteries in the presence of indomethacin (10 μM), the magnitude of acetylcholine-induced maximal relaxations (expressed as percent of maximal contractions induced by agonists) was greater in WKY compared to SHR arteries. After a 30-min incubation period, NOLA (100 μM) completely inhibited relaxations induced by acetylcholine (0.01–10 μM) in all types of precontracted arteries. Subsequent additions of sodium nitroprusside, (SNP, 10 μM) induced complete relaxations in all preparations. These results show that a basal release of NO or NO-like compound by endothelial cells is present in isolated mesenteric resistance and coronary arteries of WKY rats and SHRs. The contribution of endothelium-derived relaxing factor-nitric oxide (EDRF-NO) to arterial tone was lower in MRA compared to coronary arteries in both strains and in SHR compared to WKY arteries. In the SHR preparations, the impaired relaxation induced by acetylcholine appeared to be due to a functional alteration of the endothelium in the presence of normal reactivity of the smooth muscle cells. 相似文献
4.
5.
6.
表小檗碱对α受体的作用 总被引:2,自引:0,他引:2
表小檗碱(epiberberine,EB)是从湖北产黄连(Coptis chinensis Franch)中提取的一种生物碱,属苯喹嗪类原小檗碱,对其药理作用的研究资料甚少,未见其对α肾上腺素体作用的报道。资料表明,许多原小檗碱类化合物有α受体阻滞作用,为从该类化合物中选择 相似文献
7.
8.
9.
J M Escribà Jordana J Canela Soler M R Sala Farré A Orcau Palau 《Gaceta sanitaria / S.E.S.P.A.S》1992,6(33):257-262
In order to assess what different health care workers (mainly physicians and nursing staff) know about the reporting of communicable diseases, with special emphasis on diseases that must be urgently reported, four groups were interviewed about this health information system (91 persons, who took part in different Public Health Seminars during the periods 1989-90 and 1990-91). The total mean score was 16.6 +/- 5.2, in a quantitative scale ranging from 0 to 27 points. Cholera was the communicable disease with the highest percentage of correct answers concerning the knowledge of its reporting (100% in two groups), while typhus was the disease with the lowest percentage (23%). The diversity of the results within the study groups suggests that it is necessary to insist on a continuous training on epidemiological surveillance and communicable diseases within Public Health activities in Catalonia. 相似文献
10.