The epidemiology of cancer of the bladder in Canada: 1931 to 1985

Morbidity patterns during 1970 to 1982 and mortality patterns during 1941 to 1985, in Canada, for carcinoma of the bladder were examined. Morbidity rates in both males and females have risen, on average, by 0.39 and 0.14 additional new cases per 100,000 population per year, respectively (p≤0.015(. Analysis of age-specific morbidity rates over time revealed that these increases are associated with corresponding significant increases for six of the eight age groups studied in males (0.09 to 6.96 additional new cases per year, p≤0.035) and four of the eight age groups studied in females (0.29 to 1.59 additional new cases per 100,000 population per year, p≤0.035). Although age-standardized mortality rates for males have not changed significantly (p=0.70), rates for the six youngest age groups studied have declined significantly whereas rates for the other two (oldest) age groups have risen significantly (p≤0.030). In females, standardized mortality rates have declined by approximately 45% (p≤0.0001) with significant declines noted for six of the eight age groups studied (p≤0.025).     

3,5-甾二烯化合物的合成及抗早孕活性

以18-甲基-17β-羟基-17α-乙炔基-雌甾-4-烯-3-酮(18-甲基炔诺酮),17β-羟基-17α-乙缺基-雌甾-4-烯-3-酮(炔诺酮),17β-羟基-17α-乙炔基-雄甾-4-烯-3-酮(妊娠素)和17a-羟基孕甾-4-烯-3,20二酮(17α-羟基黄体酮)为原料,经NaBH,还原、脱水、双键转位和酯化等反应合成一系列3,5-甾二烯化合物,用¹HNMR和MS证明了它们的结构。动物筛选结果表明,17β-丙酰氧基-17α-乙炔基-雌甾-3,5-二烯(IV_b2有明显的抗早孕活性。中断早期妊娠的作用似与其雌激素活性有关。     

The epidemiology of malignant neoplasia of the larynx in Canada: 1931-1984

Canadian patterns of morbidity and mortality from laryngeal carcinoma were examined for the periods 1970-1980 and 1931-1984, respectively. Age-standardized morbidity rates had risen significantly in both males and females (P = 0.0001 and 0.0116) during 1970-1980 with rates for males increasing by more than 0.28 additional cases per 100,000 population per year since 1970. Analysis of age-specific rates over time indicates that the rise in standardized rates is attributable to significant increases in rates for males aged 45-54, 55-64 and 65-74 (P less than 0.006) and females aged 45-54, 55-64, and 75-84 (P less than 0.045). Rates for males aged 55-64 demonstrated the most dramatic rate of change of any age group at over 1.8 additional new cases per 100,000 population per year since 1970. Analysis of age-standardized mortality rates reveals that rates for males have risen significantly during the period 1931-1984 whereas rates for females have declined significantly (P = 0.0001 and 0.005, respectively). The rise in age-standardized mortality rates for males is associated with corresponding significant rates of increase in age-specific rates for males aged 45-54, 55-64, 65-74, 75-84 and 85 + (P less than 0.02) whereas the decline in rates for females is associated with significant declines in rates for women aged 35-44, 45-54, and 75-84 (P less than 0.05). Males aged 75-84 had the greatest rate of change at 0.20 additional new deaths per 100,000 population per year since 1931.     

Evaluation of encephalic ventricular volume from the magnetic resonance imaging scans of thirty-eight human subjects

Summary Accurate volume determination of the encephalic ventricles is of importance in several clinical conditions, including Alzheimer's presenile dementia, schizophrenia, and benign intracranial hypertension. Previous studies have investigated the accuracy with which magnetic resonance imaging (MRI) can be used in clinical practice to evaluate the encephalic ventricles. However, adequate evaluation of pathological conditions depends on a sufficient amount of morphometric data from normal subjects. To begin establishing this data base for normal subjects, we evaluated the MRI scans of 38 subjects found to have no apparent pathology and calculated the ventricular volume in each case by using methods previously developed in our laboratory. The results were then compared with published volumes determined from studies that used either ventricular casts or computerized tomographic scans. The average total ventricular volume for all 38 subjects was 17.4 cm³, while that for males was 16.3 cm³ and that for females was 18.0 cm³. A small but significant correlation was found between age of subject and ventricular volume, with ventricular size increasing with age.

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Evaluation du volume des ventricules cérébraux à partir des images obtenues en résonance magnétique nucléaire chez 38 sujets humains

Résumé La détermination exacte du volume des ventricules cérébraux est importante en clinique comme par exemple dans la démence présénile d'Alzheimer, la schizophrénie et l'hypertension intracrânienne bénigne. Des études antérieures ont étudié la fiabilité de la résonance magnétique nucléaire en pratique clinique pour évaluer le volume des ventricules cérébraux. Toutefois une évaluation correcte dans les conditions pathologiques implique une bonne connaissance des données morphométriques du sujet normal. Pour établir ces données sur « le sujet normal », nous avons étudié les coupes obtenues en IRM chez 38 sujets apparemment indemnes de toute pathologie; nous avons calculé le volume ventriculaire dans chaque cas en utilisant des méthodes mises au point auparavant dans notre laboratoire. Les résultats ont été ensuite comparés avec ceux obtenus par d'autres études utilisant soit des moules ventriculaires, soit des coupes tomographiques computérisées. Le volume ventriculaire total moyen chez 38 sujets est de 17,4 cm³, mais il est chez les sujets masculins de 16,3 cm³ et chez les sujets de sexe féminin de 18 cm³. Une corrélation faible mais significative a été trouvée entre l'âge du sujet et le volume ventriculaire, étant entendu que la taille du ventricule augmente avec l'âge.

     

Congenital pulmonary atresia with ventricular septal defect: angiographic and surgical correlates

Of 181 patients with severe congenital pulmonary atresia and ventricular septal defect or "type IV truncus" (an obsolete term), all but 11% had true central pulmonary arteries. These arteries were demonstrable by large serial biplane angiograms using multiple selective injections into collateral vessels, frequent photographic subtraction, and occasional pulmonary vein-wedge angiograms. These techniques are extremely important for accurate diagnosis and in planning corrective or palliative surgery, which was done in 77% of patients with pulmonary arteries.     

GD2抗体达妥昔单抗β治疗神经母细胞瘤的临床应用专家共识（2021年版）

神经母细胞瘤(neuroblastoma,NB)是儿童最常见的颅外实体肿瘤,临床表现及预后具有高度异质性。低危患儿预后较好,高危患儿即使接受化疗、放疗、手术、造血干细胞移植等多种方法的综合治疗,长期存活率仍不足50%。探索潜在的治疗靶点对于提高高危患者的生存率具有重要意义。双唾液酸神经节苷脂抗原GD2在NB细胞高表达,达妥昔单抗β可与NB细胞膜表面过表达的GD2特定靶点结合,触发抗体依赖性细胞介导的细胞毒性作用和补体依赖的细胞毒性效应,通过双重免疫机制而发挥抗肿瘤作用。通过总结国外多项关键临床研究,并结合在海南和天津医疗先行区的上市前初步应用经验,我们对达妥昔单抗β的安全性、有效性、适用人群及使用方法进行总结和推荐,提出本共识,旨在为临床医师提供指导与帮助。