全文获取类型
收费全文 | 11236篇 |
免费 | 526篇 |
国内免费 | 78篇 |
专业分类
耳鼻咽喉 | 102篇 |
儿科学 | 194篇 |
妇产科学 | 154篇 |
基础医学 | 1390篇 |
口腔科学 | 361篇 |
临床医学 | 819篇 |
内科学 | 2821篇 |
皮肤病学 | 150篇 |
神经病学 | 1062篇 |
特种医学 | 336篇 |
外科学 | 1963篇 |
综合类 | 67篇 |
一般理论 | 1篇 |
预防医学 | 352篇 |
眼科学 | 342篇 |
药学 | 814篇 |
中国医学 | 29篇 |
肿瘤学 | 883篇 |
出版年
2023年 | 61篇 |
2022年 | 117篇 |
2021年 | 202篇 |
2020年 | 101篇 |
2019年 | 157篇 |
2018年 | 196篇 |
2017年 | 156篇 |
2016年 | 211篇 |
2015年 | 210篇 |
2014年 | 244篇 |
2013年 | 273篇 |
2012年 | 499篇 |
2011年 | 557篇 |
2010年 | 363篇 |
2009年 | 278篇 |
2008年 | 461篇 |
2007年 | 504篇 |
2006年 | 508篇 |
2005年 | 521篇 |
2004年 | 486篇 |
2003年 | 486篇 |
2002年 | 496篇 |
2001年 | 397篇 |
2000年 | 345篇 |
1999年 | 367篇 |
1998年 | 157篇 |
1997年 | 113篇 |
1996年 | 122篇 |
1995年 | 96篇 |
1994年 | 88篇 |
1993年 | 96篇 |
1992年 | 280篇 |
1991年 | 222篇 |
1990年 | 192篇 |
1989年 | 223篇 |
1988年 | 197篇 |
1987年 | 222篇 |
1986年 | 185篇 |
1985年 | 181篇 |
1984年 | 134篇 |
1983年 | 111篇 |
1979年 | 123篇 |
1978年 | 60篇 |
1975年 | 61篇 |
1974年 | 69篇 |
1972年 | 58篇 |
1970年 | 73篇 |
1969年 | 55篇 |
1968年 | 64篇 |
1967年 | 62篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
2.
3.
Taichi Goto Gojiro Nakagami Takeo Minematsu Sanai Tomida Masamichi Shinoda Koichi Iwata Hiromi Sanada 《Experimental dermatology》2019,28(9):1010-1016
Cutaneous wound pain causes physical and psychological stress for patients with wounds. Previous studies reported that stress induces hyperalgesia and deteriorates wound healing. However, the effect of the stress response such as in hypothalamic‐pituitary‐adrenal (HPA) axis on local wound area is unclear. We aimed to investigate the effects of a stress response on the mechanical withdrawal threshold in the local wound area and describe the identification of a wound pain exacerbation. We topically injected adrenocorticotropic hormone (ACTH) into the granulation tissue of full‐thickness cutaneous wound model rats on the fifth day postwounding and measured the mechanical withdrawal thresholds, cytochrome P450 2Bs levels and concentration of 5,6‐epoxyeicosatrienoic acid in wound exudate. We found that ACTH induced mechanical hypersensitivity at 4 and 6 hours after injection (P = .004 and .021, respectively), and increased gene expression of cytochrome P450 2B12 expression (P = .046). Concentration of 5,6‐EET in the wound exudate was moderately correlated with the mechanical withdrawal threshold (r = ?.630). Finally, the mechanical withdrawal threshold in the 5,6‐EET group was significantly lower than that in the control group at 2 hours after the injection (P = .015). We propose that 5,6‐EET is one of the most promising contributors to the wound pain exacerbation. These findings could guide clinical wound and pain management. 相似文献
4.
5.
6.
7.
Sachiko Goto Akiyoshi Tsuji Teiko Murai Minoru Nishida Hiroko Tsukano Haruo Watanabe 《Journal of infection and chemotherapy》1998,4(1):16-19
Although there are effective antibacterial agents against plague, newer antibacterial agents have been developed which show
more potent activity against other bacterial organisms, but have not been tested againstYersinia pestis. A strain ofYersinia pestis was selected (no. 22; National Institute of Infectious Diseases, Tokyo, Japan) that caused a systemic infection in mice.Y. pestis no. 22 was intraperitoneally inoculated into DDY-strain mice, and 13 oral or 6 injectable antibacterial drugs given to the
infected mice at varying doses 1 and 24 hours after infection. Levofloxacin, sparfloxacin and ofloxacin were the most effective
oral agents against the infection, and prulifloxacin and pazufloxacin were also effective but to a lesser extent. Also, gentamicin
and arbekacin were the most potent injectable antibacterial agents againstY. pestis. These results suggest that there are several new drugs, both oral and injectable, which exert excellent in vivo antibacterial
activity against a mouse infection model and may be useful for the clinical treatment of plague. 相似文献
8.
9.
The effects of newly synthesized 5-imidazoline derivatives on the dose-response relationship to norepinephrine were investigated in the normal and denervated vasa deferentia of the rat. Three derivatives (K-3827, K-4011 and K-4300) exerted alpha-antagonistic action, the potency of which was similar to that of tolazoline. The pA2 values of these derivatives and currently known alpha-antagonists (tolazoline, phentolamine and prazosin, but not yohimbine) in the denervated tissue were slightly but significantly larger than those in the normal tissue. All imidazoline derivatives and alpha-antagonists produced an increase in the maximum response to norepinephrine in the normal vas deferens. In the denervated tissue, however, K-3827, K-4011 and alpha-antagonists caused only a rightward shift of the dose-response curve to norepinephrine, but not an increase in the maximum response, i.e., relatively pure alpha-antagonism. In contrast, the other 3 imidazoline derivatives, K-4299 and K-6342 which exhibited neither alpha-agonistic nor antagonistic action and K-4300, increased the maximum response to norepinephrine even after denervation. Their effects were nonspecific in that they also potentiated acetylcholine-induced contractions in both normal and denervated tissues. These 3 imidazoline derivatives antagonized the action of diltiazem. The effects of imidazoline derivatives and alpha-antagonists were discussed in relation to those of denervation, and the drug enhancement by 3 imidazoline derivatives was analyzed from the viewpoint of calcium movement. 相似文献
10.
A case of Ullrich disease was presented. The patient was a 3-year-old girl with torticollis, generalized muscle weakness and acroatonia since birth. High-arched palate, protruded calcaneus, and mild contracture of proximal joints were also recognized. Intellectual development was normal. Serum level of CPK was slightly increased. In histological and histochemical examinations of quadriceps femoris muscle, proliferated connective tissue, marked variation in the muscle fiber diameter, and a lot of degenerated and regenerated fibers were recognized. Minimal injury easily causes subcutaneous hemorrhage, but no abnormality was found in the structure of collagen. 相似文献