全文获取类型
收费全文 | 464篇 |
免费 | 21篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 11篇 |
妇产科学 | 2篇 |
基础医学 | 82篇 |
口腔科学 | 11篇 |
临床医学 | 22篇 |
内科学 | 63篇 |
神经病学 | 15篇 |
特种医学 | 17篇 |
外科学 | 27篇 |
综合类 | 11篇 |
预防医学 | 29篇 |
眼科学 | 3篇 |
药学 | 54篇 |
中国医学 | 1篇 |
肿瘤学 | 70篇 |
出版年
2022年 | 7篇 |
2021年 | 5篇 |
2020年 | 8篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 4篇 |
2014年 | 10篇 |
2013年 | 12篇 |
2012年 | 19篇 |
2011年 | 18篇 |
2010年 | 10篇 |
2009年 | 18篇 |
2008年 | 19篇 |
2007年 | 20篇 |
2006年 | 15篇 |
2005年 | 20篇 |
2004年 | 29篇 |
2003年 | 9篇 |
2002年 | 20篇 |
2001年 | 19篇 |
2000年 | 20篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 5篇 |
1995年 | 6篇 |
1994年 | 3篇 |
1992年 | 15篇 |
1991年 | 17篇 |
1990年 | 21篇 |
1989年 | 6篇 |
1988年 | 10篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 2篇 |
1969年 | 2篇 |
排序方式: 共有485条查询结果,搜索用时 15 毫秒
1.
The measurement of energies and intensities of fluorescent X-rays emitted from a given material when atoms are bombarded with suitable projectiles like electrons, protons, α-particles or protons has been successfully used for non-destructive elemental analysis. Use of radioisotopes as a source of exciting radiation in combination with high resolution semiconductor detectors in X-ray fluorescence has found wide applications in elemental analysis. Energy dispersive X-ray fluorescence is useful in multi-elemental analysis, and thus finds a wide variety of applications. A radioisotope excited X-ray fluorescence spectrometer consisting of a 30 mm2 × 3 mm Si(Li) detector having a resolution of 200 eV at 5.9 keV coupled to a System 100 Canberra multichannel analyser has been used. A side source geometry using 20 mCi 109Cd source together with PC AXIL software have been used for the study of environmental and geological samples in Botswana. 相似文献
2.
3.
H Sidransky E Verney C N Murty 《Laboratory investigation; a journal of technical methods and pathology》1976,34(3):291-297
The effect of tryptophan on the disaggregation of hepatic polyribosomes and on the inhibition of hepatic protein synthesis in rats due to the administration of hypertonic NaCl solutions was studied. Overnight-fasted rats were given by stomach tube or intraperitoneally hypertonic (6.2 to 10.7 per cent) NaCl alone or with 30 mg. of L-tryptophan and were killed 30 minutes later. The hypertonic NaCl treated rats revealed marked hepatic polyribosomal disaggregation and inhibition of hepatic protein synthesis (in vitro incorporation of 14C-leucine into proteins). Rats that received tryptophan alone or in a complete amino acid mixture in addition to hypertonic NaCl revealed a marked improvement in the patterns of hepatic polyribosomes and an increase in in vitro hepatic protein synthesis over that in hypertonic NaCl treated rats. The incorporation of 14C-orotate in hepatic messenger RNA (peak appearing between the 4 S and 18 S RNA fractions) associated with hepatic polyribosomes was studied. Administration of hypertonic NaCl alone caused a decrease in incorporation into hepatic messenger RNA whereas administration of hypertonic NaCl plus tryptophan caused an increase in incorporation into hepatic messenger RNA. Thus, tryptophan appears to cause an increase in hepatic messenger RNA as well as to prevent to a great extent the hepatic polyribosomal disaggregation and the inhibition of hepatic protein synthesis due to hypertonic NaCl. 相似文献
4.
Herschel Sidransky Ethel Verney Challakonda N. Murty 《Experimental and molecular pathology》1981,35(1):124-136
Female inbred Buffalo rats bearing intrahepatically transplanted hepatoma 5123 were subjected intraperitoneally to the acute administration of hypertonic NaCl or CCl4 followed by a tube-feeding of l-tryptophan. The responses in terms of changes in polyribosomal aggregation and protein synthesis (in vitro) of host liver and hepatoma were evaluated. While treatment with hypertonic NaCl or CCl4 caused disaggregation of polyribosomes and inhibition of protein synthesis in both host liver and hepatoma, the subsequent administration of tryptophan caused some improvement in both parameters in host liver but not in hepatoma. Administration of hypertonic NaCl alone caused a decrease in [14C]orotate incorporation into poly(A)-mRNA of host liver and hepatoma, whereas administration of tryptophan after hypertonic NaCl caused a significant improvement in host liver alone. Following the tryptophan administration, the activities of nuclear DNA-dependent RNA polymerases I and II, and of nuclear-envelope nucleoside triphosphatase, as well as labeled nuclear RNA release in vitro were slightly elevated in host liver but not in hepatoma. Tryptophan-related compounds, 5-hydroxy-dl-tryptophan, 5-fluorotryptophan, indole, and 3-hydroxyanthranilic acid, when administered in place of l-tryptophan, did not appreciably affect polyribosomal aggregation or protein synthesis in vitro in host liver or hepatoma. 相似文献
5.
Matthias Szabolcs Megan Keniry Laura Simpson Latarsha J. Reid Susan Koujak Sarah C. Schiff Giselle Davidian Scott Licata Sofia Gruvberger-Saal Vundavalli V.V.S. Murty Subhadra Nandula Argiris Efstratiadis Jake A. Kushner Morris F. White Ramon Parsons 《The American journal of pathology》2009,174(1):276-286
Mutations in the phosphatase and tensin homologue (PTEN)/phosphatidylinositol-3 kinase-α (PI3K) signaling pathway are frequently found in human cancer. In addition, Pten+/− mice develop tumors in multiple organs because of the activation of the PI3K signaling cascade. Because activation of PI3K signaling leads to feedback inhibition of insulin receptor substrate-2 (IRS2) expression, an upstream activator of PI3K, we therefore anticipated that IRS2 expression would be low in tumors that lack PTEN. Surprisingly, however, an elevation of IRS2 was often detected in tumor samples in which PTEN levels were compromised. To determine the potential contribution of Irs2 to tumor progression, Pten+/− mice were crossed with Irs2+/− mice. Deletion of Irs2 did not affect the initiation of neoplasia found in Pten+/− mice but suppressed cancer cell growth, proliferation, and invasion through the basement membrane. Deletion of Irs2 also attenuated the expression of Myc in prostatic intraepithelial neoplasia in Pten+/− mice. In addition, the expression levels of IRS2 and MYC were highly correlated in human prostate cancer, and IRS2 could stimulate MYC expression in cultured cells. Our findings provide evidence that the PI3K-activating adaptor Irs2 contributes to tumor progression in Pten+/− mice by stimulating both Myc and DNA synthesis. 相似文献
6.
Challakonda N. Murty PhD Ruth Hornseth BS Ethel Verney MS Herschel Sidransky MD 《Alcoholism, clinical and experimental research》1982,6(1):80-88
The effect of a single feeding of ethanol on hepatic ornithine decarboxylase (ODC) activity in rats was investigated. Ethanol (7.5 g/kg body weight) was tube-fed to overnight-fasted rats as a 50% (v/v) solution in water 1, 2, 3, 4, 8, 12, or 24 hr before sacrifice. The levels of ODC activity in the livers were assayed in vitro by measuring the release of 14 C02 from 0L-1-14 C-ornithine. Hepatic ODC activities were significantly stimulated by ethanol (7.5 g/kg body weight) beginning at 1 hr and reaching a peak at 4 hr (more than a 16-fold increase over zero time controls). Single feedings of varying doses of ethanol (2.5, 5.0, or 7.5 g/kg body weight) to overnight-fasted rats 3 hr before sacrifice also exhibited significant increases (3 to 13-fold) in the hepatic ODC activities. In vitro 14 C-leucir>e incorporation into protein using hepatic microsomes of ethanol-treated rats was decreased in comparison with that of controls. The ethanoMnduced stimulation of hepatic ODC activity was not abolished by pretreatment with pyrazoie, an inhibitor of ethanol metabolism. However, the stimulation of hepatic ODC activity by ethanol was suppressed by actinomycin D or cycloheximide, indicating that the enhancement is attributable to the synthesis of new enzyme protein. Furthermore, abolition of the stimulation of hepatic ODC activity due to ethanol by prior adrenalectomy suggests that the induced increase is probably mediated through stimulation of adrenal hormones. These studies demonstrate that a single dose of ethanol per os can significantly enhance in the rat the activity of hepatic ODC, a key enzyyme in the biosynthesis of polyamines, and that the effect is indirect, via adrenal hormones. 相似文献
7.
Jacqueline Soraru Nicole Isbel Germaine Wong Patrick Toby Coates Murty Mantha Abu Abraham Rajiv Juneja Danny Hsu Fiona Brown Bhadran Bose David Mudge Robert Carroll Joshua Kausman Peter Hughes Thomas Barbour Anne Durkan Peter Mount Darren Lee Nicholas Larkins Dwarakanathan Ranganathan Wai H. Lim 《Nephrology (Carlton, Vic.)》2020,25(9):683-690
8.
Uppuluri Venkata Mallavadhani Laxmidhar Sahoo Koochana Pranay Kumar Upadyayula Suryanarayana Murty 《Medicinal chemistry research》2014,23(6):2900-2908
As a part of our program to generate some novel flavonoid frameworks substituted with higher alkyl groups as possible antimicrobial agents, we have in total synthesized twelve novel chalcones (11–16) and their corresponding flavanones (17–22) substituted with either nonyl or dodecyl chains in ring B in very good to excellent yields. The synthesized compounds have been screened for their antimicrobial potential against six bacterial and four fungal strains. The tested compounds, in general, showed significant antibacterial and comparable antifungal activities. While the chalcone (16) with a dodecyl chain showed highly promising antibacterial activity against almost all the organisms tested, the chalcone (13) with nonyl chain showed promising antifungal activity against Candida rugosa and Aspergillus niger strains. 相似文献
9.
Characterization of the promoter region of the gene for the rat neutral and basic amino acid transporter and chromosomal localization of the human gene. 总被引:2,自引:1,他引:2
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.
Christopher B. Anderson Michael Lipsky Subhadra V. Nandula Christopher E. Freeman Thomas Matthews Caitlin E. Walsh Gen Li Matthias Szabolcs Mahesh M. Mansukhani James M. McKiernan Vundavalli V. Murty 《Genes, chromosomes & cancer》2020,59(1):6-12
The cytogenetic alterations in renal oncocytoma (RO) are poorly understood. We analyzed 130 consecutive RO for karyotypic alterations. Clonal chromosome abnormalities were identified in 63 (49%) cases, which could be categorized into three classes of mutually exclusive cytogenetic categories. Class 1 (N = 20) RO had diploid karyotypes with characteristic 11q13 rearrangement in balanced translocations with 10 or more different chromosome partners in all cases. We identified recurrent translocation partners at 5q35, 6p21, 9p24, 11p13‐14, and 11q23, and confirmed that CCND1 gene rearrangement at 11q13 utilizing fluorescence in situ hybridization (FISH). Class 2 RO (N = 25) exhibited hypodiploid karyotypes with loss of chromosome 1 and/or losses of Y in males and X in females in all cases. The class 3 tumors comprising of 18 cases showed diverse types of abnormalities with the involvement of two or more chromosomes exclusive of abnormalities seen in classes 1 and 2 tumors. Furthermore, karyotypically uninformative cases were subjected to FISH analysis to identify classes 1 and 2 abnormalities. In this group, we found similar frequencies of CCND1 rearrangement, loss of chromosome 1 or Y as with karyotypically abnormal cases. We validated our results against 91 tumors from the Mitelman database. Correlation of clinical data with all the three classes of ROs showed no clear evidence of overall patient survival. Our findings support the hypothesis that RO exhibit three principal cytogenetic categories, which may have different roles in initiation and/or progression. These cytogenetic markers provide a key tool in the diagnostic evaluation of RO. 相似文献