全文获取类型
收费全文 | 3282篇 |
免费 | 351篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 55篇 |
妇产科学 | 116篇 |
基础医学 | 421篇 |
口腔科学 | 66篇 |
临床医学 | 463篇 |
内科学 | 812篇 |
皮肤病学 | 17篇 |
神经病学 | 235篇 |
特种医学 | 161篇 |
外科学 | 411篇 |
综合类 | 73篇 |
一般理论 | 4篇 |
预防医学 | 416篇 |
眼科学 | 34篇 |
药学 | 198篇 |
肿瘤学 | 111篇 |
出版年
2023年 | 21篇 |
2022年 | 32篇 |
2021年 | 63篇 |
2020年 | 40篇 |
2019年 | 59篇 |
2018年 | 68篇 |
2017年 | 47篇 |
2016年 | 36篇 |
2015年 | 45篇 |
2014年 | 72篇 |
2013年 | 141篇 |
2012年 | 195篇 |
2011年 | 161篇 |
2010年 | 117篇 |
2009年 | 108篇 |
2008年 | 151篇 |
2007年 | 189篇 |
2006年 | 157篇 |
2005年 | 149篇 |
2004年 | 138篇 |
2003年 | 132篇 |
2002年 | 149篇 |
2001年 | 84篇 |
2000年 | 100篇 |
1999年 | 84篇 |
1998年 | 28篇 |
1997年 | 32篇 |
1996年 | 37篇 |
1995年 | 33篇 |
1994年 | 32篇 |
1993年 | 36篇 |
1992年 | 57篇 |
1991年 | 40篇 |
1990年 | 67篇 |
1989年 | 49篇 |
1988年 | 47篇 |
1987年 | 42篇 |
1986年 | 37篇 |
1985年 | 29篇 |
1984年 | 40篇 |
1983年 | 35篇 |
1982年 | 30篇 |
1981年 | 36篇 |
1980年 | 37篇 |
1979年 | 37篇 |
1978年 | 25篇 |
1977年 | 33篇 |
1976年 | 30篇 |
1975年 | 20篇 |
1966年 | 22篇 |
排序方式: 共有3642条查询结果,搜索用时 312 毫秒
1.
Suchi Raghunathan Corey L. Reynolds Robert J. Schwartz M. David Stewart Bradley K. McConnell 《Fundamental & clinical pharmacology》2019,33(1):25-30
Inbred mouse strains are the most widely used mammalian model organism in biomedical research owing to ease of genetic manipulation and short lifespan; however, each inbred strain possesses a unique repertoire of deleterious homozygous alleles that can make a specific strain more susceptible to a particular disease. In the current study, we report dystrophic cardiac calcinosis (DCC) in C.B‐17 SCID male mice at 10 weeks of age with no significant change in cardiac function. Acquisition of DCC was characterized by myocardial injury, fibrosis, calcification, and necrosis of the tissue. At 10 weeks of age, 38% of the C.B‐17 SCID mice from two different commercial colonies exhibited significant calcinosis on the ventricular epicardium, predominantly on the right ventricle. The frequency of calcinosis was more than 50% for mice obtained from Taconic's Cambridge City colony and 25% for mice obtained from Taconic's German Town colony. Interestingly, the DCC phenotype did not affect cardiac function at 10 weeks of age. No differences in echocardiography or electrocardiography were observed between the calcinotic and non‐calcinotic mice from either colony. Our findings suggest that C.B‐17 SCID mice exhibit DCC as early as 10 weeks of age with no significant impact on cardiac function. This strain of mice should be cautiously considered for the study of cardiac physiology. 相似文献
2.
3.
4.
5.
6.
G. Bradley Schaefer James N. Thompson John B. Bodensteiner James M. McConnell William J. Kimberling Charles T. Gay William D. Dutton David C. Hutchings Stanton B. Gray 《Annals of neurology》1996,39(3):382-385
There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dys- genesis likely to be solely responsible for clinical autistic behaviors. 相似文献
7.
Syntheses of several tripeptide analogues of leupeptin containing C-terminal argininal, lysinal, or ornithinal units are presented. The synthetic analogues were tested as inhibitors of trypsin, plasmin, and kallikrein. (Benzyloxycarbonyl)-L-leucyl-L-leucyl-L-argininal (2a) was significantly less effective as an inhibitor of trypsin and plasmin activity than leupeptin. (Benzyloxycarbonyl)-L-leucyl-L-leucyl-L-lysinal (2e) and (benzyloxycarbonyl)-L-leucyl-L-leucyl-L-ornithinal (2i) display different inhibition characteristics than (benzyloxycarbonyl)-L-leucyl-L-leucyl-L-argininal (2a). While (benzyloxycarbonyl)-L-leucyl-L-leucyl-L-argininal (2a) showed moderate inhibition of all three enzymes tested, (benzyloxycarbonyl)-L-leucyl-L-leucyl-L-lysinal (2e) was less effective as an inhibitor of trypsin and plasmin activity. Of the three enzymes tested, (benzyloxycarbonyl)-L-leucyl-L-leucyl-L-ornithinal (2i) showed significant inhibition of kallikrein activity only. Modifications made in the composition and sequence of the P2 and P3 amino acids also resulted in variations in the inhibitory activity of the analogues. In general, plasmin showed a strong preference for inhibitors which contain an L-phenylalanyl-L-leucyl or an L-leucyl-L-valyl unit in the P2 and P3 positions. 相似文献
8.
9.
10.
Serum and peritoneal dialysate thyroid hormone levels in patients on continuous ambulatory peritoneal dialysis 总被引:1,自引:0,他引:1
Thyroid function tests were performed on 16 clinically euthyroid patients with end-stage renal failure undergoing regular haemodialysis or continuous ambulatory peritoneal dialysis and compared with 8 healthy subjects. The patient groups were carefully matched, especially regarding relative duration of dialysis (mean of 24 months). Total serum thyroxine, total triiodothyronine, free thyroxine, free triiodothyronine and reverse triiodothyronine were significantly lower in both patient groups than control. The thyrothrophin response to the standard thyrotrophin-releasing hormone test was delayed and blunted. Using a novel concentration technique we measured loss of T4 in peritoneal dialysate effluent and found it to be approximately 10% of daily thyroidal T4 release. 相似文献