全文获取类型
收费全文 | 6020篇 |
免费 | 251篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 106篇 |
妇产科学 | 39篇 |
基础医学 | 856篇 |
口腔科学 | 73篇 |
临床医学 | 334篇 |
内科学 | 1533篇 |
皮肤病学 | 62篇 |
神经病学 | 574篇 |
特种医学 | 259篇 |
外科学 | 1228篇 |
综合类 | 19篇 |
预防医学 | 172篇 |
眼科学 | 89篇 |
药学 | 344篇 |
中国医学 | 5篇 |
肿瘤学 | 577篇 |
出版年
2023年 | 34篇 |
2022年 | 63篇 |
2021年 | 124篇 |
2020年 | 74篇 |
2019年 | 92篇 |
2018年 | 107篇 |
2017年 | 90篇 |
2016年 | 106篇 |
2015年 | 116篇 |
2014年 | 165篇 |
2013年 | 225篇 |
2012年 | 381篇 |
2011年 | 392篇 |
2010年 | 197篇 |
2009年 | 171篇 |
2008年 | 343篇 |
2007年 | 394篇 |
2006年 | 390篇 |
2005年 | 403篇 |
2004年 | 384篇 |
2003年 | 396篇 |
2002年 | 357篇 |
2001年 | 63篇 |
2000年 | 55篇 |
1999年 | 79篇 |
1998年 | 98篇 |
1997年 | 95篇 |
1996年 | 89篇 |
1995年 | 77篇 |
1994年 | 64篇 |
1993年 | 61篇 |
1992年 | 58篇 |
1991年 | 46篇 |
1990年 | 57篇 |
1989年 | 50篇 |
1988年 | 29篇 |
1987年 | 36篇 |
1986年 | 31篇 |
1985年 | 27篇 |
1984年 | 34篇 |
1983年 | 33篇 |
1982年 | 33篇 |
1981年 | 16篇 |
1980年 | 25篇 |
1979年 | 10篇 |
1978年 | 12篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1974年 | 15篇 |
1972年 | 11篇 |
排序方式: 共有6293条查询结果,搜索用时 62 毫秒
1.
Toshihiro Yoshitake Akira Takeda Kensaku Ohki Yuko Inoue Takanori Yamawaki Saori Otsuka Minekatsu Akimoto Mitsuru Nemoto Yasuhito Shimakura Akio Sato 《The Journal of dermatology》2015,42(7):735-738
Finasteride is standard medical treatment for androgenetic alopecia; however, no large studies with 5 years or more of follow up have been performed in Japan. The authors followed Japanese men with androgenetic alopecia treated with finasteride for 5 years to evaluate long‐term treatment efficacy. Of 903 men treated with finasteride (1 mg/day), 801 patients were evaluated over 5 years by modified global photographic assessment. Although the proportion of improvement was high (99.4%), modified global photographic assessment scores after 5 years of treatment were lower in patients with more advanced disease as measured by the modified Norwood–Hamilton scale. After separating patients into “sufficient” and “insufficient” efficacy groups according to the modified global photographic assessment score after 5 years (scores ≥6 and <6, respectively), multivariate analysis showed that independent risk factors of insufficient efficacy were age at start of treatment of 40 years or more (P = 0.021) and classification on the modified Norwood–Hamilton scale (P < 0.001), whereas presence of stress at start of treatment was a negative predictor (P = 0.025). In conclusion, continuous finasteride treatment for 5 years improved androgenetic alopecia with sustained effect among Japanese. Younger age and less advanced disease at start of treatment were the key predictors of higher finasteride efficacy. 相似文献
2.
3.
Xin Mei Jiang Akio Ohnishi Tatsunori Yamamoto Yoshiyuki Murai Akira Awaya Masato Ikeda 《Acta neuropathologica》1995,90(2):130-134
One of the pyrimidine compounds, 2-piperadino-6-methyl-5-oxo-5,6-dihydro(7H)pyrrolo[3,4-d]pyrimidine (MS-818), has neurotropic effects in vitro. Therefore, we studied the effect of MS-818 on the regeneration of the peroneal nerve in C57BL/6J mice after a crush injury. Two test groups, which received a daily intraperitoneal injection of 5 mg/kg or 10 mg/kg MS-818, respectively, were compared with controls, which received daily intraperitoneal injections of physiological saline, over a 14-day period. The maximum foot-width ratio (crushed side/uncrushed side) was obtained on days 1, 8 and 14 after the crush injury, and the various morphometric parameters were evaluated at both 5 and 10 mm distal to the proximal portion of the crush site. The significant effects of MS-818 included a larger maximum foot width (P<0.04) and a greater number of unmyelinated axons per nerve at both levels (P<0.003) in both test groups than in controls. MS-818 had no significant effects on body weight, the increase of total transverse fascicular area after the crush injury, the total number of myelinated fibers with their size distributions, or the number of nuclei of Schwann cells and macrophages. Therefore, we conclude that MS-818 promotes axonal sprouting and elongation after a crush injury in mice. 相似文献
4.
The effect of intraosseous graft length on tendon-bone healing in anterior cruciate ligament reconstruction using flexor tendon 总被引:1,自引:1,他引:0
Shuji Yamazaki Kazunori Yasuda Fumihisa Tomita Akio Minami Harukazu Tohyama 《Knee surgery, sports traumatology, arthroscopy》2006,14(11):1086-1093
The current study was performed to understand the relationship between graft length placed within the bone tunnel and intraosseous graft healing in anterior cruciate ligament (ACL) reconstruction. Twenty-four adult beagle dogs were divided into two groups of 12 animals each. In each animal, ACL reconstruction using a 4-mm diameter autogenous flexor tendon graft was done in the left knee. In groups I and II, the graft having a length of 15 and 5 mm, respectively, was placed within the tibial tunnel. The proximal end of the graft was placed through the over-the-top route in all animals. In each group, five animals were sacrificed immediately after surgery, and the remaining seven were sacrificed at 6 weeks postoperatively. Biomechanical and histologic evaluations were performed. In pull out testing, the ultimate failure load and the linear stiffness of the graft-tibia complex harvested at 6 weeks were significantly greater than those harvested at the time-zero period. There were no significant differences in those parameters between groups I and II at 6 weeks. In each group, the perpendicular collagen fibers connecting the tendon to the bone tunnel wall were observed only in the narrow area located close to the intra-articular tunnel outlet. In conclusion, excessively long placement of the flexor graft within the bone tunnel does not result in an additional increase of anchoring strength and stiffness of the graft in ACL reconstruction. 相似文献
5.
Akio Suzumura 《Nihon shinkei seishin yakurigaku zasshi》2005,25(5):239-243
Microglia are only one type of professional immune cells in the central nervous system, functioning as scavenger cells that remove pathogens, and as antigen presenting cells that present brain-specific antigens to invading T cells. They also play a critical role in the pathophysiology of various CNS disorders as effector cells to destroy neural cells by secreting inflammatory cytokines, radicals, and glutamate. At the same time, they can protect neural functions by producing neurotrophic factors. Thus, to study the mechanisms for regulation of microglial functions may be useful for understanding the etiology and future therapeutic strategy for intractable neurological disorders. 相似文献
6.
H Iwanami M Saitoh K Narita M Tachibana K Hasegawa M Sakonzi E Tuboi 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(3):211-214
Of 200 lung cancer lesions resected in our hospital, there were 15 cases (7.5%) with middle lobe origin. The histological types were adenocarcinoma in 13 patients (4 patients with alveolar cell carcinoma), squamous cell carcinoma in one and large cell carcinoma in one. These patients were classified into two groups according to the type of operation they received and each group was evaluated. Group I (resection of the middle lobe) included 8 patients. Each one of Stage IIIB and Stage IV received the operation to improve their symptoms. The six patients of Stage I received only middle lobectomy as absolute curable cases. Group II (resection of the middle and lower lobes) included 7 patients, who had preoperative diagnosis of stage III. Two of them were postoperatively found to be cases of Stage I and Stage II. Although it was still short-term, the follow-up evaluation proved that these patients survived without local recurrence and distant metastasis, except for two with pleural dissemination and one with cerebral metastasis, who had received lobectomy as palliative operation. No difference was observed between the two groups receiving different types of operation. 相似文献
7.
Yawata Ayumi; Kanzaki Akio; Gilsanz Florinda; Delaunay Jean; Yawata Yoshihito 《Blood》1997,90(6):2471-2481
8.
9.
Masato Sasaki Seiya Hirai Masakazu Kawabe Takahiko Uesaka Kouichi Morioka Akio Ihaya Kuniyoshi Tanaka 《European journal of cardio-thoracic surgery》2005,27(2):307-312
OBJECTIVE: The baseball-diamond principle is generally used for trocar placement during video-assisted thoracic surgery; however, we are unable to treat all peripheral lung lesions using this principle. Therefore, we have developed another method for determining trocar placement based on a modification of the conventional principle. We have termed this method the triangle target principle. This report describes the instrument positioning that we now use for many video-assisted thoracic surgical procedures. METHODS: We position 3 trocars in an equilateral triangle, with the target lesion at the apex. One vertex of the base becomes the site of the first trocar placement for introduction of the thoracoscopic camera. Another vertex of the base becomes the site for the second trocar for forceps or the endoscopic stapler. The third trocar is for forceps and is inserted to create the vicinity of target lesion. Four types of the triangle target principle were developed according to sites of the target lesion. RESULTS: Between January 2000 and December 2002, we used this principle for 161 patients who underwent video-assisted thoracic surgery and all intrathoracic lesions were accessible except in 3 patients requiring intraoperative modifications. CONCLUSIONS: We conclude that video-assisted thoracic surgery by this principle is more effective and easier than the conventional principle to treat intrathoracic disease. 相似文献