1960-2000年加拿大人非黑色素瘤皮肤癌的发病趋势

非黑色素瘤皮肤癌(NM SC)是高加索人群中特别常见的皮肤恶性肿瘤。但是在加拿大人群中的发病率却少有报道。作者选择了1960-2000年所有马尼托巴省首次报道的N M SC病例,对其发病率和危险性的历史变迁进行了研究。得到了NM SC的发病率和终生危险性。皮肤基底细胞癌(BCC)是NM SC一个主要类型,大约占到79%。从20世纪70年代至2000年,40岁以上人群中,BCC和鳞状细胞癌的发病率每年以2.4%的速度递增。与20世纪60年代相比,20世纪90年代NM SC的终生危险性增加了2～3倍。作者认为,由于NM SC对资源利用和治疗成本有较大影响,以及其容易预防…     

表现为荨麻疹样斑块和嗜酸性细胞增多症的急性成淋巴细胞性白血病患儿1例

作者报道 1例既往健康的 10岁女孩,发现有荨麻疹样 斑块和 轻度的食 欲不振 ,初步 实验室 检查发现其增高的白细胞数达 30000/μL,外周血嗜酸细胞计数22500/μL。皮肤活组织检察显示明显的高敏组织反应,具有丰富的嗜酸粒细胞。粪便中进一步的外周嗜酸性粒细胞检查发现兰伯贾第虫。尽管用抗寄生虫药物呋喃唑酮治疗,患者的荨麻疹样斑块、白细胞计数和外周嗜酸细胞计数仍保持不变,骨髓活检证实为急性成淋巴细 胞 性白 血 病 (A LL )。 伴 有嗜 酸 细 胞增 多 症的 A L L(A L L /E o)是 A LL 很少见的一种亚型,文献报道有 30多例。文章讨…     

皮肤科门诊患者就诊期间是否对其生活质量进行过充分讨论?

背景:皮肤科医生评估皮肤病如何影响患者的生活质量,对临床决策非常重要。然而目前还没有关于门诊患者生活质量(QoL)问题讨论频率的资料。目的:研究皮肤科门诊患者就诊期间QoL相关问题讨论频率与疾病对患者当前生活影响之间的关系。患者和方法:在一个教学性皮肤科门诊部收集238     

Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma

Melanoma consists 4-5 % of all skin cancers, but it contributes to 71-80 % of skin cancers deaths. UV light affects cell and tissue homeostasis due to its damaging effects on DNA integrity and modification of expression of a plethora of genes. DNA repair systems protect cells from UV-induced lesions. Several animal models of melanoma have been developed (Xiphophorus, Opossum Monodelphis domestica, mouse models and human skin engrafts into other animals). This review discusses possible links between UV and genes significantly related to melanoma but does not discuss melanoma genetics. These include oncogenes, tumor suppressor genes, genes related to melanocyte-keratinocyte and melanocyte-matrix interaction, growth factors and their receptors, CRH, ACTH, α-MSH, glucocorticoids, ID1, NF-kappaB and vitamin D3.     

Stroke Care in 2006,Did We Make Any Progress?

As it was in the past, stroke care made exciting progress but at the same time, there was disappointment in 2006. Although many clinical trials have published their results in the areas ranging from stroke risk factor management, stroke prevention, acute stroke intervention, complication management to rehabilitation, very few conclusions can be applied to our clinical practice. While we continue to gain knowledge on the risk factor management, such as the need to aggressively lowering cholesterol, we need more data on the efficacy and safety of carotid artery stenting. The search for more effective therapies to treat acute ischemic strokes and intracerebral hemorrhages continues.As it was in the past, stroke care made exciting progress but at the same time, there was disappointment in 2006. Although many clinical trials have published their results in the areas ranging from stroke risk factor management, stroke prevention, acute stroke intervention, complication management to rehabilitation, very few conclusions can be applied to our clinical practice. While we continue to gain knowledge on the risk factor management, such as the need to aggressively lowering cholesterol, we need more data on the efficacy and safety of carotid artery stenting. The search for more effective therapies to treat acute ischemic strokes and intracerebral hemorrhages continues.     

Immunochemical studies on blood groups; the methylpentose contents of hog and human blood group A and O substances and their relationship to cross-reactivity with type XIV antipneumococcus horse serum

It has been possible, by employing a new color reaction for methylpentoses, to determine the fucose content of individual hog and human blood group A, B, and O substances. The data indicate an inverse correlation between fucose content of the hog A and O substances and ability to cross-react with Type XIV antipneumococcus serum. The human A, B, and O substances display no correlation between their fucose content and ability to cross-react with Type XIV antipneumococcus serum.