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外用中药瘢痕膏对兔耳瘢痕模型表皮生长因子及局部愈合的影响 总被引:1,自引:2,他引:1
目的:瘢痕膏由对抑制瘢痕、止痒有效地验方配制而成,且已经临床证实对增生性瘢痕有防治作用。观察瘢痕膏对创面是否有促进愈合作用。方法:实验于2007-01在广西医科大学实验室完成。①实验分组:选用新西兰大耳白兔12只,体质量2kg左右,随机数字表法分为实验组、对照组和空白组,每组8只兔耳。②实验方法:适应性喂养24h,制备兔耳瘢痕模型,每只兔耳建立6个创面,即每组48个创面。实验组和对照组于瘢痕模型建立后24h开始用药,实验组采用瘢痕膏涂抹创面(瘢痕膏为一种外用中药制剂,其主要成分为丹参酮、积雪甙、黄芪甙、甘草酸、苦参碱等,按3∶3∶2∶2∶1的比例加基质制作而成);对照组采用湿润烧伤膏涂抹;空白组涂抹基质;连续用药30d。③实验评估:用药第6,12,18,24天观察各组瘢痕组织颜色、质地的变化及创面愈合情况;用药第7,14,21天检测各组标本白细胞计数及生长因子(表皮生长因子、碱性成纤维细胞生长因子)的表达。结果:纳入实验兔12只(24只耳),中途无脱失。①用药后第14天,实验组圆形创面局部稍隆起,对照组和空白组也有如上表现,3组瘢痕在外观形态上无明显差别;用药第28天,实验组瘢痕略高于兔耳皮肤表面,颜色稍红,触之质软;其余两组明显高于兔耳皮肤表面,颜色较红,质地硬。②用药第24天,实验组兔耳的创面愈合情况要好于其他两组。③用药第14天和第28天,3组间创面的白细胞计数无显著差异(P>0.05)。④用药第21天,实验组和对照组表皮生长因子的表达差异无显著性意义(P>0.05),但两组都高于空白组(P<0.05);第7,14,21天的数据显示,实验组和对照组碱性成纤维细胞生长因子的表达亦无显著差异(P>0.05),但都高于空白组(P<0.05)。结论:此外用中药在创伤早期应用,对创面的愈合具有促进作用。 相似文献
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丹参总酮对体外模拟人增生性瘢痕的作用 总被引:1,自引:0,他引:1
增生性瘢痕是创伤及深度烧伤后常见的病理性愈合现象.寻求有效防治增生性瘢痕的方法是创伤修复领域的重要课题.中药治疗增生性瘢痕历史悠久[1],其毒性作用及不良反应轻微,但机制不明.丹参广泛用于心血管疾病、皮肤病及胶原代谢疾病等领域,也常用于治疗或预防增生性瘢痕及瘢痕疙瘩,有文献报道其疗效显著[2].本研究中,笔者选择丹参总酮为研究用药,将其用于体外人增生性瘢痕三维模型,观察其抑制瘢痕增生的效果,以期为临床上防治增生性瘢痕提供实验依据. 相似文献
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Objective To study the effect of hirudin on the function of human hyperplastic scar fi-broblasts (HSFBs). Methods HSFBs were cultured in vitro. Hirudin solution in the concentration of 1, 10, and 50 kU/L was respectively added into DMEM culture medium to form 1, 10, and 50 kU/L hirudin groups, with 9 wells in each group. HSFBs cultured without hirudin were set up as control group. Cell inhi-bition rate, secretion level of TGF-β1 from cells, and expression levels of mRNA of type Ⅰ and Ⅲ precolla-gem were determined at 24, 48, and 72 h after culture. Results Inhibition rates of HSFBs growth was re-spectively ( 29.3 ± 0.9) % , ( 30.1 ± 0.3 ) % , and (45.2 ± 1.9 ) % when cultured with 10 kU/L hirudin for 24, 48, and 72 hs, which were higher than those in control group [ (0.0±0.0)% , P <0.05]. There was statistically significant difference between control group and 1 and 50 kU/L hirudin groups in the inhibition rates of HSFBs at some time points ( P <0.05). Secretion level of TGF-β1 of HSFBs in 1, 10, 50 kU/L hirudin groups was respectively (228.5±1.8), (210.5±11. 1), and (168.5±14.1) pg/mL when cul-tured for 48 hs, of which the last 2 figures were significantly lower than that of control group [ (265.0±1.5) pg/mL, P < 0.05 ]. Hirudin in the concentration of 10 and 50 kU/L could inhibit the expression of mRNA of type Ⅰ and Ⅲ precollagen in HSFBs. Conclusions Hirudin solution in the concentration of 10 and 50 kU/L can inhibit the proliferation of HSFBs and secretion of TGF-β1 and collagen in certain degree. 相似文献
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目的:研究水蛭素对体外人增生性瘢痕模型的收缩能力,成纤维细胞的增殖、胶原分泌等功能的影响。方法:体外培养人增生性瘢痕成纤维细胞(HSFB),建立含增生性瘢痕成纤维细胞的胶原网架系统(FPCL),用1、10、50U/ml的水蛭素溶液干预该模型,测定凝胶块收缩指数,利用MTT染色计数活细胞,逆转录多聚酶链式反应(RT-PCR)法检测细胞Ⅰ、Ⅲ型前胶原mRNA表达。结果:浓度为10U/ml和50U/ml水蛭素溶液能够抑制HSFB的活力,使FPCL收缩指数降低,抑制FPCL中HSFBⅠ、Ⅲ型前胶原mRNA的表达(P<0.05)。结论:水蛭素溶液可抑制体外人增生性瘢痕三维模型的收缩功能和成纤维细胞增殖、分泌胶原功能。 相似文献
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患儿男,11个月。发热11天、右臀部出现红肿9天。皮损渐扩大加重,出现腰背、臀部、右大腿皮肤片状坏死,质硬呈黑色。皮损组织病理符合坏死性筋膜炎。全麻下行坏死创面清除并予植皮,20天后治愈出院。 相似文献
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