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1.
Objective To investigate the role of inflammatory cytokines in the pathogenesis of chronic non-bacterial prostatitis/chronic pelvic pain syndrome (CAP/CPPS) patients. Methods The 38 cases with CAP/CPPS patients (18 cases of CAP and 20 cases of CPPS) and 20 cases of healthy controls were selected. The differential expressions of 40 kinds of inflammatory cytokines were detec-ted by antibody arrays in prostate fluid. Results The inflammatory cytokines which increased more than 1.5 times expression have been found. There were seven kinds in CAP including monocyte che-moattractant protein (MCP)-1, solution tumor necrosis factor receptor Ⅱ(s TNF R Ⅱ), platelet-de-rived growth faetor-BB (PDGF-BB), interleukin (IL)-β, IL-11、IL-6、MCP-2 and five kinds in CPPS groups including MCP-1、PDGF-BB、MCP-2、s TNF R Ⅱ、It-11 respectively, compared with healthy control group. The cluster analysis results showed that protein expression of Monocyte chemoattrac-tant protein 1 (MCP-1)and platelet-derived growth factor BB (PDGF-BB) were significantly increased in CAP (3.47 and 2.07 times) and CPPS (2.25 and 2.19 times) compared with healthy control group and were the final polymerization of inflammatory cytokines. The protein expression of interleukin 1 β (IL-1 β), MCP-1 and soluble tumor necrosis factor Ⅱ (s TNF R Ⅱ) in CAP group was increased more than 1.85,1.55,1.67 times compared with CPPS group. Conclusions Elevated expression of inflammatory cytokines may play an important role in the course of CAP/CPPS disease. The extent of the inflammatory response of CAP was higher than CPPS. The inflammatory factors of MCP-1 and PDGF-BB could serve as a novel diagnostic marker. 相似文献
2.
最近,30多岁的陈先生查出患了痛风,服用了很多药后发现自己出现勃起功能障碍.痛风会影响男性性功能吗?
1.什么是痛风?
痛风是一种由于嘌呤生物合成代谢增加,尿酸产生过多或因尿酸排泄不良而致血中尿酸升高,尿酸盐结晶沉积在关节滑膜、滑囊、软骨及其他组织中引起的反复发作性炎性疾病.本病以关节液和痛风石中可找到有双折光性的单水尿酸钠结晶为特点. 相似文献
3.
目的:观察三橘荔核汤对CAP/CPPS患者前列腺液MCP-1、PDGF-BB表达的影响。方法:将符合CAP/CPPS(气滞血瘀型)诊断标准的患者70例随机分为治疗组和对照组各35例,治疗组采用三橘荔核汤口服,对照组采用前列腺汤口服,均以10 d为1个疗程,共3个疗程。观察两组患者临床疗效、NIH-CPSI积分及前列腺液中细胞因子MCP-1、PDGF-BB水平的变化。结果:两组治疗后综合疗效比较,差异有统计学意义(P0.05);NIH-CPSI积分比较,差异有统计学意义(P0.05);MCP-1、PDGF-BB的表达,差异均有统计学意义(P0.05)。结论:三橘荔核汤治疗CAP/CPPS患者临床疗效显著,其作用机理可能是通过调控炎症因子MCP-1、PDGF-BB的表达从而达到免疫调节作用。 相似文献
4.
PPH术与Milligan-Morgan 术治疗重度混合痔的疗效比较 总被引:1,自引:0,他引:1
目的:比较PPH术与Milligan-Morgan术治疗重度混合痔的疗效。方法:将84例重度混合痔患者随机分为PPH术组与Milligan-Morgan术组各42例。分别采用吻合器痔上黏膜环形切除术(procedure for prolapse and hemorrhoids,PPH)和Milligan-Morgan术。观察两组手术时间、住院天数、疼痛、出血、尿潴留、直肠黏膜下血肿、肛门狭窄、肛门失禁、痔脱垂、肛缘水肿、肛门坠胀等情况。结果:两组在上述指标方面均有统计学意义(P<0.05);仅尿潴留方面比较差异无统计学意义(P>0.05)。结论:吻合器痔上黏膜环形切除术治疗重度混合痔疗效显著。 相似文献
5.
6.
目的 观察益肾通癃颗粒对人前列腺癌PC3细胞荷瘤裸鼠Wnt/β-catenin信号通路的干预作用。方法 利用人前列腺癌骨转移细胞PC3建立前列腺癌荷瘤裸鼠模型,将其随机分为模型对照组、阳性药物组、益肾通癃颗粒低剂量组、益肾通癃颗粒中剂量组、益肾通癃颗粒高剂量组和联合用药组,给予相应的药物干预,连续4周。给药结束后处死动物获取皮下移植瘤瘤体组织样本,分别进行HE染色观察病理变化,免疫组化检测细胞增殖情况,TUNEL检测细胞凋亡情况,Western blot及免疫组织化学法检测Wnt信号通路相关基因蛋白的表达水平。结果 益肾通癃颗粒可以有效改善荷瘤裸鼠皮下移植瘤瘤体组织的病理改变,可以显著抑制肿瘤细胞的增殖,促进细胞凋亡的发生,药效呈浓度依赖性。益肾通癃颗粒还可以下调Wnt/β-catenin信号通路相关基因Wnt1、Wnt3a、β-catenin、APC蛋白的表达(P<0.01),上调Wnt/β-catenin信号通路相关基因GSK-3β蛋白的表达(P<0.01),降低p-GSK-3β蛋白的活性(P<0.01),药效与剂量呈正相关性,与Wnt信号通路阻断剂ICG联合时效... 相似文献
7.
目的:探讨安糖通痹方治疗大鼠糖尿病周围神经病变作用机制.方法:用小剂量链脲佐菌素(STZ)诱导的方法建立2型DPN大鼠模型,选取健康大鼠50只,随机分为正常组、安糖通痹方小剂量组、大剂量组和VitB12组,分别测定造模前后ET水平及NO水平,进行对比分析.结果:造模成功后各用药组血清NO水平明显低于正常组(P<0.05),ET水平明显高于正常组(P<0.05);经治疗后,安糖通痹方大剂量组的大鼠血清NO显著升高(与小剂量组、VitB12组比较,P<0.05),大鼠血浆ET显著降低(与小剂量组、VitB12组比较,P<0.05).结论:安糖通痹方可以升高血清NO水平,降低ET含量,具有对周围神经和血管的保护作用,且大剂量组效果优于小剂量组. 相似文献
8.
9.
目的探讨肿瘤坏死因子—α(TNF-α)基因启动子-308位多态性与慢性非细菌性前列腺炎,慢性骨盆疼痛综合征中医证型的相关性。方法采用PCR-R FLP技术结合ELISA法。对115例CPPS患者和21例非CPPS健康人群前列腺液TNF-α水平及启动子-308位基因多态性进行检测。并对其与中医证型的相关性进行了分析。结果CPPS组TNF-α2等位基因型频率显著高于健康对照组,OR=6.286(95%CI1.471-26.850,P〈0.01)。中医证型中。湿热蕴阻证、湿热挟瘀证与TNF—α基因启动子308-2基因型相关。与气滞血瘀证及健康对照组比较差异显著(P〈0.05)。结论TNF-α2等位基因可能与CPPS的易感性相关,并可能是CPPS中医证型中湿热蕴阻证、湿热挟瘀证的易感基因。 相似文献
10.
Objective To investigate the role of inflammatory cytokines in the pathogenesis of chronic non-bacterial prostatitis/chronic pelvic pain syndrome (CAP/CPPS) patients. Methods The 38 cases with CAP/CPPS patients (18 cases of CAP and 20 cases of CPPS) and 20 cases of healthy controls were selected. The differential expressions of 40 kinds of inflammatory cytokines were detec-ted by antibody arrays in prostate fluid. Results The inflammatory cytokines which increased more than 1.5 times expression have been found. There were seven kinds in CAP including monocyte che-moattractant protein (MCP)-1, solution tumor necrosis factor receptor Ⅱ(s TNF R Ⅱ), platelet-de-rived growth faetor-BB (PDGF-BB), interleukin (IL)-β, IL-11、IL-6、MCP-2 and five kinds in CPPS groups including MCP-1、PDGF-BB、MCP-2、s TNF R Ⅱ、It-11 respectively, compared with healthy control group. The cluster analysis results showed that protein expression of Monocyte chemoattrac-tant protein 1 (MCP-1)and platelet-derived growth factor BB (PDGF-BB) were significantly increased in CAP (3.47 and 2.07 times) and CPPS (2.25 and 2.19 times) compared with healthy control group and were the final polymerization of inflammatory cytokines. The protein expression of interleukin 1 β (IL-1 β), MCP-1 and soluble tumor necrosis factor Ⅱ (s TNF R Ⅱ) in CAP group was increased more than 1.85,1.55,1.67 times compared with CPPS group. Conclusions Elevated expression of inflammatory cytokines may play an important role in the course of CAP/CPPS disease. The extent of the inflammatory response of CAP was higher than CPPS. The inflammatory factors of MCP-1 and PDGF-BB could serve as a novel diagnostic marker. 相似文献