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微粉化乌贝分散片工艺研究及药效验证 总被引:1,自引:0,他引:1
目的筛选微粉化乌贝分散片的处方和制备工艺,对剂型改变前后的药效进行比较。方法按照《中国药典》2005年版附录对分散片的要求,以休止角、硬度、外观、脆碎度、分散均匀性做为考察指标筛选处方和工艺,采用小鼠利血平胃溃疡模型考察两种剂型药效变化。结果按优选处方制备微粉化乌贝分散片,可在3min内完全崩解,且同等剂量下药效优于散剂。结论微粉化乌贝分散片服用、携带及药效明显优于散剂。 相似文献
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目的:对观察风府刺血疗法改善脑卒中后口腔期吞咽障碍的临床疗效,为临床脑卒中后吞咽障碍患者提供一种新方法。方法:将符合脑卒中诊断标准并伴有口腔期吞咽障碍的68例脑卒中患者,采用随机单盲平行对照和患者自身前后对照的研究方法分为治疗组与对照组,每组34例,两组按洼田饮水试验进行评估,两组给予相同的背景治疗,治疗组在对照组基础治疗上加用风府刺血疗法,每周2次,4周为1个疗程,1个疗程结束后再按洼田饮水试验进行评估,比较两组治疗方法对脑卒中口腔期吞咽障碍影响的差异。结果:治疗组和对照组的吞咽障碍在治疗后均有明显改善,组间比较有明显差异(P<0.05)。结论:风府刺血法可以提高脑卒中后口腔期吞咽障碍疗效。 相似文献
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目的研究肌电触发电刺激疗法对脑卒中患者手功能的影响。方法脑卒中患者40例分为肌电触发电刺激疗法组(肌电触发组)19例,神经肌肉电刺激疗法组21例(NMES组),比较两组治疗前后Fugl-Meyer上肢功能评分、改良Barthel指数、腕背伸主动关节活动度。结果两组患者治疗后各项评分均有显著提高(P<0.001);与NMES组比较,肌电触发组各项评分均有提高(P<0.05)。结论肌电触发电刺激疗法可有效改善偏瘫患者手功能障碍,疗效优于神经肌肉电刺激疗法。 相似文献
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中医康复学是一门研究、应用传统中医方法结合各种运动治疗技术促进伤病患者身心功能恢复的学科.它以“中医整体观念”为指导思想,突出应用传统中医疗法,在伤病的早期介入,以恢复功能为目的,促进患者最大限度地回归社会.中医康复学是临床型学科,以培养临床实用型人才为教育的主要目标. 相似文献
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BACKGROUND: Different training methods have different effects on primary knee osteoarthritis.
OBJECTIVE: To compare the effects of uphill or downhill running on articular cartilage degeneration and inflammatory responses of knee osteoarthritis rats.
METHODS: 108 female Sprague-Dawley rats were randomly divided into six groups: normal control group, ovariectomized group, uphill running group (run & up), downhill running group (run & down), uphill running model group (model & up), downhill running model group (model & down). The rats in the normal control group were raised routinely with no treatment; rats in the ovariectomized group were ovarientomized and raised in routine way; rats in the run & up group and run & down group were subjected to uphill running training on the slop +15° or downhill running training on the slop -15°; rats in the model & up group and model & down group were subjected to uphill running training on the slop +15°or downhill running training on the slop -15° after ovarientomized. Training programs were as follows: 28 m/min, 60 minutes per day, 6 days per week.
RESULTS AND CONCLUSION: Compared with the other five groups, in the model & up group, the Mankin’s score was significantly increased, indicating that articular cartilage degeneration occurred, and the peak of carboxy-terminal telopeptide of type II collagen contained in the urine had passed, at 4 weeks after modeling. At 6 weeks, the Mankin’s score of the model & down group was increased to reach the degeneration standard, but it was still lower than that of the model & up group; the expression levels of tumor necrosis factor-α and interleukin-1β in the synovial fluid were significantly higher in the model & up and model & down groups than the other four groups. At 8 weeks, the Mankin’s score and the expression levels of tumor necrosis factor-α and interleukin-1β were further increased in the model & up and model & down groups, especially in the model & up group. These results indicate that treadmill running exercise after ovariectomized can result in articular cartilage injury and local inflammatory responses; compared with the downhill running training, the uphill running training can cause cartilage injury earlier and more efficiently. 相似文献
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目的:建立联合酶联免疫的微量病毒中和法(ELISA-MVN法),用于大流行流感疫苗流感病毒中和抗体效价的检测,并进行方法学验证。方法:采用4种羊抗流感病毒血清参考品,与人感染禽流感H5N1病毒疫苗株(A/Vietnam/1194/2004-NIBRG-14)病毒液,分别于37℃孵育18 h后,固定细胞,ELISA检测细胞内流感病毒核蛋白表达,确定其中和抗体效价,考察该方法的特异性;通过对高中低不同抗体滴度的血清样本的多次平行检测来评价该方法的重复性;通过ELISAMVN法和血凝抑制试验(HI试验)分别检测大流行流感疫苗接种者血清样本,比较2种方法的灵敏性和相关性。结果:ELISA-MVN结果显示羊抗H5N1的血清中和抗体检测滴度为5 120,其他3种血清的中和抗体滴度小于10,该方法特异性良好;采用ELISA-MVN法对3种不同滴度的血清进行重复检测,组内重复性试验的6次平行试验结果的RSD为3.5%。组间重复性5次结果,RSD为4.8%~8.6%。2种方法测定疫苗接种者血清样本抗体效价的结果具有显著相关性(P<0.001),相关系数r=0.932。ELISA-MVN法检测结果的几何平均滴度高于HI试验检测结果,该方法较HI试验在检测大流行流感疫苗血清样本灵敏度高。结论:ELISA-MVN可满足大流行流感疫苗血清学检测的要求,并可用于评价大流行流感疫苗的免疫效果。 相似文献
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表面肌电可以在运动过程中记录神经电信号,反映肌肉活动,被应用于观察慢性腰痛患者躯干和下肢肌肉活动。通过对比腰痛患者与正常人在不同活动下的不同肌电信号特征,可以为慢性腰痛的发病机制、诊疗研究提供新思路。 相似文献