创伤性隔疝12例的诊疗体会

创伤性膈疝在胸腹部创伤中发生率不高 ,但伤情及症状复杂 ,易被延误诊治。 1 987年 3月至 1 998年 5月我院共收治 1 2例 ,现报告如下。1　临床资料1 .1　一般资料 :1 2例中男 1 0例 ,女 2例 ,年龄 1 8～ 50岁 ,30岁以下 9例。闭合性挤压伤 1 0例 ,开放性锐器伤 2例。左侧膈疝 1 1例 ,右侧膈疝 1例。1 1例伤后即有不同程度胸腹痛及进行呼吸困难、心悸、紫绀 ,于 2 4小时内来诊 ,1例伤后 5月始出现食欲不振、恶心、腹胀、胸腹痛方来诊。伴患侧肩背部放射痛 6例 ,患侧胸部隆起 5例 ,叩诊鼓音 3例 ,浊音 3例 ,听诊有肠鸣音 3例 ,胸穿出出胃内容…     

不同季节新生儿硬肿症分析比较

目的 了解新生儿硬肿症的发病与季节的关系,寻找不同季节的主要致病因素。方法 按春夏秋冬四季进行统计,找出各季节主要的致病因素。结果 总体上新生儿硬肿症的发病冬春季多于夏秋季,其比为３：２。早产为主要致病因素,在一年四季中均占有较高比例（６５．２３％）,感染和窒息是夏秋季新生儿硬肿症的主要致病因素之一,夏秋季硬肿症患儿合并感染或窒息的比例明显高于冬春季（Ｐ＞０．０５）。结论 寒冷损伤是新生儿硬肿症主     

高热惊厥合并抗利尿激素异常分泌综合征的研究

【目的】　探讨高热惊厥 (FC)是否会合并抗利尿激素异常分泌综合征 (SIADH) ,FC在 1次病程中再发惊厥是否与合并SIADH有关。　【方法】　测定 74例FC患儿 (其中在病程中无再发惊厥者 46例 ,有再发惊厥者 2 8例 )及 60例有发热但无惊厥的单纯上呼吸道感染者的血钠、尿钠、血和尿渗透压。　【结果】　在 74例FC患儿中检出合并SIADH者 18例 ,单纯上感组中未检出合并SIADH者。合并SIADH的FC患儿 66.67%发生再次惊厥 (12 /18) ,未合并SIADH的FC患儿发生再次惊厥者仅为 2 8.5 7% (16/5 6)。差异有非常显著性 (χ2 =8.40 46,P <0 .0 1)。　【结论】　高热惊厥可以合并SIADH ,合并SIADH的高热惊厥患儿在病程中发生再次惊厥的危险性高于未合并SIADH者。     

创伤性膈疝12例的诊疗体会

目的探讨创伤性膈疝的临床特点、诊断与治疗方法。方法回顾分析12例创伤性膈疝的诊断与不同手术路径的修复过程。结果10例治愈,2例死亡。结论X线检查是诊断的重要依据;手术有多种路径,其选择以能解除对病人生命最大威胁为原则。     

HACCP与GMP、ISO9000族质量保证体系在食品工业中的应用

认识食品安全性问题的诸多方面，理顺影响食品安全性链条上的各种关系，建立保证食品安全的有效监控管理体系，是包括生产者、经营者、消费者、管理者在内的全社会关注的焦点。传统的监管模式，对食品卫生的控制重点是放在对成品的监督检查上，对成品进行监督抽检是对上市销售产品的一种监管手段，可直接反映产品的安全性。     

Omi/HtrA2在窒息后血清诱导人近曲肾小管皮细胞凋亡中的作用

Objective To investigate the mechanism of inducing apoptosis of Omi/HtrA2 in renal tubular cells with postasphyxial serum of neonate. Methods Human renal proximal tubular cell line HK-2 cell was used as target cell. They were divided into three groups: control group, asphyxia group and Ucf-101 (Omi/HtrA2 special inhibitor) treated group. The challenge concentration of serum obtained from neonates 24 hours after asphyxia was 20%,and the treatment concentration of Ucf-101 was 10 μmol/L.The Omi/HtrA2 translocation in renal tubular cells was observed with confocal microscopy, and the rate of apoptosis was detected with flow cytometer. Results It was found that Omi/HtrA2 was translocated into cytoplasm in asphyxia group, and the rate of Omi/HtrA2 translocation in HK-2 cells of asphyxia group was significantly increased [(28. 1 % vs. (9.4±2.1)%, P<0. 01]. Compared with the control group, after being treated with postasphyxial serum, the rate of apoptosis of HK-2 cells in asphyxia group wa ssignificantly increased [(36. 3±4. 4)% vs. (12. 4±2. 9) %, P<0. 01]. Compared with asphyxia group, the rate of apoptosis in HK-2 cells in Ucf-101 treated group was significantly decreased [(27. 0± 3. 9)% vs. (36.3±4.4) %, P<0. 01]. Conclusion These experimental data demonstrates that postasphyxial serum of neonate can induce apoptosis of HK-2 cells, and translocation of Omi/HtrA2 from mitochondria into cyto-plasm may play an important role in its intracellular signal transduetion mechanism in induction of apoptosis.     

Omi/HtrA2在窒息后血清诱导人近曲肾小管皮细胞凋亡中的作用

Objective To investigate the mechanism of inducing apoptosis of Omi/HtrA2 in renal tubular cells with postasphyxial serum of neonate. Methods Human renal proximal tubular cell line HK-2 cell was used as target cell. They were divided into three groups: control group, asphyxia group and Ucf-101 (Omi/HtrA2 special inhibitor) treated group. The challenge concentration of serum obtained from neonates 24 hours after asphyxia was 20%,and the treatment concentration of Ucf-101 was 10 μmol/L.The Omi/HtrA2 translocation in renal tubular cells was observed with confocal microscopy, and the rate of apoptosis was detected with flow cytometer. Results It was found that Omi/HtrA2 was translocated into cytoplasm in asphyxia group, and the rate of Omi/HtrA2 translocation in HK-2 cells of asphyxia group was significantly increased [(28. 1 % vs. (9.4±2.1)%, P<0. 01]. Compared with the control group, after being treated with postasphyxial serum, the rate of apoptosis of HK-2 cells in asphyxia group wa ssignificantly increased [(36. 3±4. 4)% vs. (12. 4±2. 9) %, P<0. 01]. Compared with asphyxia group, the rate of apoptosis in HK-2 cells in Ucf-101 treated group was significantly decreased [(27. 0± 3. 9)% vs. (36.3±4.4) %, P<0. 01]. Conclusion These experimental data demonstrates that postasphyxial serum of neonate can induce apoptosis of HK-2 cells, and translocation of Omi/HtrA2 from mitochondria into cyto-plasm may play an important role in its intracellular signal transduetion mechanism in induction of apoptosis.     

凯时治疗急性脑梗死的近期疗效观察

目的：观察凯时治疗急性脑梗死的疗效。方法：选取急性期脑梗死患者，随机分为两组各30例。治疗组在常规治疗的基础上加用凯时，对照组只用常规治疗。采用全国第四届脑血管病学术会议通过“脑卒中患者临床神经功能缺损程度评分标准”进行疗效评定。结果：两周后评定临床神经功能缺损程度，结果凯时治疗急性脑梗死疗效优于对照组。结论：凯时治疗急性脑梗死疗效明显，副作用小，可作为治疗急性脑梗死的主要药物之一。     

丙泊酚、咪唑安定、硫喷妥钠用于全麻诱导复合用药对循环影响的观察

丙泊酚、咪唑安定和硫喷妥钠是全麻常用的诱导药，近年来常将其相互复合使用，以期降低气管插管应激反应，防止循环系的过度扰乱。我院采用的三种全麻诱导药复合使用方法，下文将三法对循环系影响的观察比较结果加以报道，以供临床选择参考。     

高雪氏病二例报告

高雪氏病较少见。本文报告2例均表现有肝脾肿大、贫血,骨髓涂片查到高雪氏细胞而确诊;一例脾脏切除作病检证实。切脾后半年随访,骨髓仍可查见高雪细胞,但症状明显好转。