银杏提取物对外周动脉阻塞性病人的血液流变学和行走的研究

AIM: To study the effects of Ginkgo biloba extract 761 (GbE) from the points of view of hemorheology for patients of peripheral arterial occlusive diseases (PAOD). METHODS: The treatment with GbE (240 mg.d-1, po) and the pain-free walking distance (PFWD) were carried out for 24 PAOD patients (12 nondiabetic, ND and 12 diabetic, D) over 48 wk. The parameters erythrocyte stiffness (ES) and relaxation time (RT), the blood plasma viscosity (eta), the plasma fibrinogen concentration (Cf) and the blood sedimentation rate (BSR), the PFWD, and maximal walking distance (MWD) were determined at 6 wk before treatment (-6), at the beginning of the treatment (0), and after 6, 11, 16, and 48 wk of treatment. RESULTS: At wk -6, ES and RT of both the ND- and D-group were not significantly different from a healthy control group. At wk 0, stiffness and RT were significantly higher than healthy control, and the mean PFWD was only 111 m. The eta value was significantly elevated and Cf and BSR were enhanced. Throughout 11 wk of treatment ES, RT, eta, and Cf decreased gradually and PFWD improved. Between 16 and 48 wk, ES, and RT were no longer significantly different from the controls, whereas eta and Cf decreased gradually but remained higher than normal, BSR decreased, and the PFWD improved by a factor of 3.8 times (D) and 3.3 times (ND). CONCLUSION: GbE gives therapeutic effects in PAOD patients.     

Hemorheology and walking of peripheral arterial occlusive diseases patients during treatment with Ginkgo biloba extract

Ｉｎｐｅｒｉｐｈｅｒａｌａｒｔｅｒｉａｌｏｃｌｕｓｉｖｅｄｉｓｅａｓｅｓ（ＰＡＯＤ），ｅｌｅｖａｔｅｄｂｌｏｄｖｉｓｃｏｓｉｔｙ，ｉｎｃｒｅａｓｅｄｐｌａｓｍａｆｉｂｒｉｎｏｇｅｎｌｅｖｅｌｓ，ａｌｔｅｒｅｄｅｒｙｔｈｒｏｃｙｔｅａｇｇｒｅｇａｔｉｏ...     

两种微创融合术治疗退行性腰椎滑脱的比较

[目的]比较内镜经椎间孔腰椎间融合术（endoscopic transforaminal lumbar interbody fusion, E-TLIF）与斜外侧腰椎椎间融合术（oblique lumbar interbody fusion, OLIF）治疗退行性腰椎滑脱（degenerative spondylolisthesis, DS）的临床效果。[方法]2019年4月—2021年1月本院手术治疗82例DS患者。根据术前医患沟通结果，41例行E-TLIF术，41例行OLIF术。比较两组围手术期指标、随访及影像资料。[结果]两组患者均顺利完成手术，均未发生严重并发症。OLIF组手术时间、切口总长度、术中失血量、术中透视次数、下地行走时间、住院时间均显著优于E-TLIF组（P<0.05）。OLIF组术后1d时ESR、PCT、β-EP均显著低于E-TLIF组（P<0.05）。随着时间推移，两组VAS评分、ODI评分均显著减少（P<0.05）,JOA评分均显著增加（P<0.05），术后1周、术后3个月时OLIF组VAS评分均显著低于E-TLIF组（P<0.0...