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目的 运用数据挖掘技术分析国内外针灸治疗阿尔茨海默病的选穴规律。方法 检索建库至2020年12月31日中国期刊全文数据库(CNKI)、维普中文期刊服务平台(VIP)、万方数据知识服务平台(Wanfang)、Web of Science、Pubmed、Embase、Cochrane Library数据库收录的针灸治疗阿尔茨海默病的相关文献,采用Microsoft Excel 2019建立针灸处方数据库,对腧穴、经脉进行频数统计,并运用IBM SPSS Modeler 18.0软件对腧穴、经脉进行关联规则分析。结果 共纳入182篇文献,包括308个针灸处方、96个腧穴,腧穴使用总频次为1 928次。其中,主要选取的经脉为督脉及足三阳经;腧穴主要分布于头面、下肢和上肢;累计应用频次最高的腧穴为百会、四神聪、足三里;特定穴多使用交会穴;腧穴配伍以大椎→百会最为常见。结论 国内外针灸治疗阿尔茨海默病重视督脉及足三阳经的使用;取穴以近部取穴及远近配穴为主;重视特定穴使用,尤其是交会穴。 相似文献
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ObjectiveTo compare the clinical effects of body acupuncture, moxibustion, and body acupuncture plus moxibustion in the treatment of post-stroke shoulder hand syndrome (SHS).MethodsA total of 90 SHS patients after stroke were randomly divided into the body acupuncture group, the moxibustion group, and the body acupuncture plus moxibustion group, with 30 cases in each. On the basis of rehabilitation and routine treatment, the patients in different groups were treated with body acupuncture, moxibustion, and body acupuncture plus moxibustion respectively. Treatment was given once a day, 5 times a week, and 4 weeks in all. The visual analogue scale (VAS) scores, edema grading scores, and simplified Fugl-Meyer assessment (FMA) scores were evaluated before and after treatment, and the therapeutic effects of patients were evaluated as well.ResultsAfter treatment, the VAS and edema grading scores of the three groups were all lower and the FMA scores were all higher than those before treatment, with statistically significant differences (all P<0.05). The VAS and edema grading scores of the acupuncture plus moxibustion group were lower and the FMA score was higher than those of the body acupuncture group and the moxibustion group, with statistically significant differences (all P<0.05). The total effective rate of the acupuncture plus moxibustion group was 96.7%, higher than 80.0% of the body acupuncture group and 83.3% of the moxibustion group, with statistically significant differences (both P<0.05).ConclusionBody acupuncture, moxibustion, and body acupuncture plus moxibustion are all effective for post-stroke SHS, while the effect of acupuncture plus moxibustion is the best in relieving the pain and swelling, and improving effectively the joint movement of post-stroke SHS patients, which should be popularized in clinical practice. 相似文献
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Objective To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods By searching journal literature on chronic gastritis treated with acupuncture and moxibustion in recent 10 years, with data mining, the acupoints screened from literature were analyzed.Results A total of 803 articles were included finally. Conception vessel, stomach meridian and bladder meridian were mostly selected, the acupoints were selected from the abdomen, the thigh/crus, the back and the arms. The top 5 aucpoints with high frequency were Zúsānl? (足三里ST36), Zhōngw?n (中脘CV12), Wèishū (胃俞BL21) (332), Píshū (脾俞BL20) and Nèiguān (内关PC6). The top 5 acupoint combinations with high frequency included CV12 combined with ST36, BL21 with CV12, BL21 with ST35 and BL20 with CV12. The mostly used specific points were front-mu point, he-sea point, crossing point and back-shu point.Conclusion In treatment of chronic gastritis with acupuncture and moxibustion, conception vessel, stomach meridian and bladder meridian are particularly selected in combination and the specific points with duplicate effect are mostly selected, especially focusing on the application of front-mu point. 相似文献
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目的:观察电针大肠俞募穴天枢大肠俞对慢传输型便秘(STC)大鼠肠道传输功能的改善情况,通过检测大鼠结肠组织胶质细胞源性神经营养因子(GDNF)的表达以及GDNF基因启动子区CpG岛甲基化状态,探讨电针治疗STC的可能机制。方法:雄性SD大鼠随机分为正常组、盐水组、模型组和电针组,每组16只。采用15 mg/mL复方地芬诺酯混悬液灌胃(10 mL·kg-1·d-1)复制STC大鼠模型。盐水组予同等剂量的0.9%氯化钠溶液灌胃。电针组电针双侧天枢大肠俞,每次15 min, 1次/d,连续14 d。观察大鼠排便情况并检测大鼠肠道传输功能;采用透射电镜观测结肠组织Cajal间质细胞(ICC)超微结构;Western blot法、实时荧光定量PCR法检测结肠组织中GDNF蛋白、mRNA的表达;重亚硫酸盐测序法检测结肠组织GDNF基因启动子区CpG岛甲基化状态。结果:与正常组、盐水组比较,模型组大鼠24 h排便量下降(P<0.01),粪便性状评分降低(P<0.05),小肠推进率下降(P<0.01),ICC形态结构遭到破坏... 相似文献
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目的:分析胰腺导管腺癌患者转化生长因子(TGF)-β/SMAD4信号通路中基因突变的情况及对生存的影响。方法:回顾性分析天津医科大学总医院普通外科2016年7月—2019年9月共19例胰腺导 管腺癌患者的临床资料,NGS检测患者基因突变情况,查询dbSNP及COSMIC数据库关键基因突变位点的临床意义。结果:19例胰腺导管腺癌患者中最常见的基因突变是 KRAS(84.2%)、TP53(68.4%)、 SMAD4(26.3%)、CDKN2A(26.3%)、CREBBP(15.8%)、RNF43(15.8%)、BRAF(15.8%)等。具有TGF-β/SMAD4信号通路相关基因突变的患者有7例(36.8%),其中SMAD4基因突变组中位生存时间5.0个 月,无SMAD4基因突变组中位生存时间14.0个月,差异有统计学意义(P=0.032)。结论: TGF-β/SMAD4信号通路中具有SMAD4基因突变患者的临床预后相较于无基因突变患者的临床预后更差,此通路中 具有多个基因突变其预后相对更差。 相似文献