全文获取类型
收费全文 | 266794篇 |
免费 | 11774篇 |
国内免费 | 707篇 |
专业分类
耳鼻咽喉 | 4990篇 |
儿科学 | 9782篇 |
妇产科学 | 6672篇 |
基础医学 | 35974篇 |
口腔科学 | 9451篇 |
临床医学 | 19410篇 |
内科学 | 52976篇 |
皮肤病学 | 7663篇 |
神经病学 | 23168篇 |
特种医学 | 11016篇 |
外国民族医学 | 28篇 |
外科学 | 40892篇 |
综合类 | 1744篇 |
一般理论 | 65篇 |
预防医学 | 18245篇 |
眼科学 | 6358篇 |
药学 | 18276篇 |
中国医学 | 1035篇 |
肿瘤学 | 11530篇 |
出版年
2023年 | 1520篇 |
2022年 | 2299篇 |
2021年 | 4706篇 |
2020年 | 2916篇 |
2019年 | 4255篇 |
2018年 | 6435篇 |
2017年 | 4651篇 |
2016年 | 5550篇 |
2015年 | 6114篇 |
2014年 | 7565篇 |
2013年 | 10400篇 |
2012年 | 15151篇 |
2011年 | 15257篇 |
2010年 | 8727篇 |
2009年 | 6975篇 |
2008年 | 12979篇 |
2007年 | 14086篇 |
2006年 | 13557篇 |
2005年 | 13976篇 |
2004年 | 13073篇 |
2003年 | 12615篇 |
2002年 | 12132篇 |
2001年 | 8543篇 |
2000年 | 8831篇 |
1999年 | 7405篇 |
1998年 | 2226篇 |
1997年 | 1875篇 |
1996年 | 1404篇 |
1995年 | 1182篇 |
1994年 | 1085篇 |
1993年 | 947篇 |
1992年 | 3098篇 |
1991年 | 2903篇 |
1990年 | 2863篇 |
1989年 | 2597篇 |
1988年 | 2303篇 |
1987年 | 2228篇 |
1986年 | 2062篇 |
1985年 | 1977篇 |
1984年 | 1493篇 |
1983年 | 1234篇 |
1979年 | 1617篇 |
1978年 | 1186篇 |
1975年 | 1183篇 |
1974年 | 1285篇 |
1973年 | 1161篇 |
1972年 | 1143篇 |
1971年 | 1131篇 |
1970年 | 1024篇 |
1969年 | 992篇 |
排序方式: 共有10000条查询结果,搜索用时 437 毫秒
1.
Georg Prokop Benedikt Wiestler Daniel Hieber Fynn Withake Karoline Mayer Jens Gempt Claire Delbridge Friederike Schmidt-Graf Nicole Pfarr Bruno Märkl Jürgen Schlegel Friederike Liesche-Starnecker 《International journal of cancer. Journal international du cancer》2023,153(9):1658-1670
Intratumor heterogeneity is a main cause of the dismal prognosis of glioblastoma (GBM). Yet, there remains a lack of a uniform assessment of the degree of heterogeneity. With a multiscale approach, we addressed the hypothesis that intratumor heterogeneity exists on different levels comprising traditional regional analyses, but also innovative methods including computer-assisted analysis of tumor morphology combined with epigenomic data. With this aim, 157 biopsies of 37 patients with therapy-naive IDH-wildtype GBM were analyzed regarding the intratumor variance of protein expression of glial marker GFAP, microglia marker Iba1 and proliferation marker Mib1. Hematoxylin and eosin stained slides were evaluated for tumor vascularization. For the estimation of pixel intensity and nuclear profiling, automated analysis was used. Additionally, DNA methylation profiling was conducted separately for the single biopsies. Scoring systems were established to integrate several parameters into one score for the four examined modalities of heterogeneity (regional, cellular, pixel-level and epigenomic). As a result, we could show that heterogeneity was detected in all four modalities. Furthermore, for the regional, cellular and epigenomic level, we confirmed the results of earlier studies stating that a higher degree of heterogeneity is associated with poorer overall survival. To integrate all modalities into one score, we designed a predictor of longer survival, which showed a highly significant separation regarding the OS. In conclusion, multiscale intratumor heterogeneity exists in glioblastoma and its degree has an impact on overall survival. In future studies, the implementation of a broadly feasible heterogeneity index should be considered. 相似文献
2.
Rizzo Manglio Miguel Bluthgen Mara Virginia Recondo Gonzalo Naveira Martin Perfetti Aldo Rizzi Florencia Kuzminin Alejandro Faura Victoria Cerini Matas Videla Alejandro Silva Carlos Lupinacci Lorena Minatta Nicols 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(6):1057-1064
International Journal of Clinical Oncology - Immune-checkpoint inhibitors (ICIs) are standard treatments for metastatic non-small cell lung cancer (NSCLC). Patients with poor performance status... 相似文献
3.
Vilar-Compte Mireya Gaitán-Rossi Pablo Félix-Beltrán Lucía Bustamante Arturo V. 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(1):65-77
Journal of Immigrant and Minority Health - COVID-19 has disproportionally affected underrepresented minorities (URM) and low-income immigrants in the United States. The aim of the study is to... 相似文献
4.
Esin Benli Küçük Ercan Kaydok Kürsad Ramazan Zor Gamze Yıldırım Biçer 《Topics in stroke rehabilitation》2020,27(8):630-635
ABSTRACT Objective: Dry eye is reported to be associated with several neurological diseases. The aim of this study is to evaluate the patients with hemiplegia after stroke for dry eye and compare their results with a control group. Materials and methods: Forty-five patients with hemiplegia and 45 individuals as the control group were included in the study. Tear function tests (Schirmer and tear breakup time) and a dry eye questionnaire for dry eye symptoms (ocular surface disease index) were performed and the results of the two groups were compared. Results: Schirmer test results were significantly lower in the post-stroke hemiplegia group compared to the control group (11.3 ± 8.2 mm and 20.6 ± 11.6 mm, respectively, p < .001). Tear breakup time results were significantly lower in the post-stroke hemiplegia group compared to the control group (7.9 ± 3.1 s and 12.1 ± 4.3 s, respectively, p < .001). Ocular surface disease index scores were not significantly different between hemiplegia and control groups (21.6 ± 20.0 and 19.8 ± 13.9, respectively, p = .635). Schirmer scores lower than 10 mm (60% and 30%, p < .001) and tear breakup time results lower than 10 s (65.6% and 28.9%, p < .001) were also higher in the hemiplegia group compared to control group. Conclusion: We found lower Schirmer test and tear breakup time results and similar OSDI scores in hemiplegia patients compared to controls. Hemiplegia patients may have dry eye without typical symptoms. This should be taken into consideration in the follow-up and rehabilitation of post-stroke hemiplegia patients. 相似文献
5.
6.
7.
María del Carmen Azorín Samper Marta Hernandorena Gonzlez Alberto Ibez Arias Sandra Díaz Sierra Marta Bertolo Domínguez Flix Checa Ayet 《The breast journal》2020,26(2):252-254
Breast pseudoaneurysms after a core needle biopsy are a rare complication with a low incidence. However, it is important to be aware of the possibility of complications that require treatment. 相似文献
8.
9.