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1.
E A Zillmer C Waechtler B Harris F Khan P C Fowler 《Archives of clinical neuropsychology》1992,7(1):29-40
An exploratory maximum likelihood factor analysis of the inter-correlations among the 11 subtests of the WAIS-R was undertaken for 167 patients who had a primary diagnoses of cerebrovascular accident (right hemisphere, n = 79; left hemisphere, n = 55; diffuse or multifocal, n = 33). On the WAIS-R, this sample performed below normative standards (average scaled score = 7.1), but demonstrated a pattern of variability among subtests similar to the normative groups. Interestingly, VIQ-PIQ discrepancy analyses revealed V > P profiles for patients with lesions in either or both hemispheres. The best fit for the WAIS-R matrix was an oblique two-factor model comprised of the Verbal and Performance subtests. This factor solution, which was moderately correlated (.52), accounted for 58.8% of the total variance. The stability of a two-factor structure in this neurologic impaired population suggests that the WAIS-R is a robust measure, even when used within such a rehabilitation population. Only two of the eleven subtests (i.e., Comprehension and Picture Arrangement), however, were related to lesion site. Rehabilitation settings may need to rely more on neuropsychological procedures that measure the more "fluid" areas of neurocognitive ability, in contrast to the WAIS-R which appears less sensitive to the neurological impairment associated with stroke. 相似文献
2.
Lars T. Sørensen MD ; Lars N. Jorgensen MD DMSc ; Rikke Zillmer PhD ; Jakob Vange MSc ; Ulla Hemmingsen RN ; Finn Gottrup MD DMSc 《Wound repair and regeneration》2006,14(3):247-251
Cigarette smokers deposit less collagen, expressed as hydroxyproline, in granulation tissue than nonsmokers. We studied the effect of abstinence from smoking and transdermal nicotine patches on deposition of hydroxyproline, proline, type I procollagen, and total proteins. Fifty-four healthy smokers were studied during 10 days of smoking and again from days 10 to 20 following smoking cessation. After the first 10 days of abstinence they were randomized to double-blind treatment with transdermal nicotine patches of 25 mg/day or placebo for a period of 10 days. During this period and during smoking, an expanded polytetrafluoroethylene tube was implanted into the subcutis. Following removal of the implant, total amino acids and peptides were extracted. Hydroxyproline and proline were analyzed by high-pressure liquid chromatography, type I procollagen was analyzed by enzyme-linked immunoassay, and total proteins were determined colorimetrically. In the 39 subjects who complied with the study protocol, abstinence from smoking did not affect the deposition of hydroxyproline, proline, type I procollagen, or total protein in the implants. During abstinence, the type I procollagen level increased by 18% in the transdermal nicotine patches group and decreased by 10% in the placebo group (p<0.05). We conclude that 20 days of abstinence from smoking does not affect collagen deposition in granulation tissue. However, in abstinent smokers, transdermal nicotine patches appears to increase type I collagen synthesis. 相似文献
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Ziemke P. Fraenckel Panse Weimann Jendralski Vorschütz Wachholz B. Mueller Giese Schwarz Hans Strauss Hecht Wietrich Urechia Kurt Mendel F. Stern Ostertag Tietze Kehrer Einar Sjövall G. Michelsson v. Neureiter Klestadt Ruge Kappus Zillmer Reisner Otte H. Merkel 《International journal of legal medicine》1933,21(2-3):85-100
Ohne Zusammenfassung 相似文献
5.
Zillmer R Trøstrup H Karlsmark T Ifversen P Agren MS 《Archives of dermatological research》2011,303(8):601-606
Wound fluid collected from chronic wounds may be used as a simple gauge of the processes taking place in the tissue. There
is lack of information on the optimal conditions for wound fluid procurement. We have studied possible diurnal variations
and duration of wound fluid accumulation using retentive hydrophobic foam on the levels of prototypic cytokines [interleukin
(IL)-1α, IL-1β], a chemokine (IL-8) and proteinases [matrix metalloproteinase (MMP)-9] in 23 chronic venous leg ulcer patients.
Bioactivity of 1 and 24 h wound fluids, and serum was also compared. There were no significant temporal changes in the levels
of the above-mentioned four proteins, when comparing three consecutive 8-h intervals starting from 0800 that in turn did not
differ significantly with the 24-h collection levels. IL-1α, IL-1β and IL-8 levels were higher (p < 0.05) in 24 h compared with 1 h wound fluids, whereas MMP-9 levels were insensitive to the length of collection. The 24 h
wound fluids did not elicit DNA synthesis in adult human dermal fibroblasts in contrast to the 1 h wound fluids (p = 0.046) and serum (p = 0.036). The polyurethane foam alone had no significant effects on the concentration of the examined analytes. The length
of collection is critical when monitoring cytokine/chemokine and bioactivity levels of chronic wound fluid. The removal of
accumulating unfavorable factors in chronic wound fluid may be important in wound management. 相似文献
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7.
In the current study, the Tower of London (Shallice, 1982) was modified to enhance its clinical utility as a measure of childhood executive functioning. The Tower of London-Drexel (TOL(DX)) was administered to normal control (NC; N = 56) and attention-deficit hyperactivity disorder (ADHD; N = 99) children (ages 7 to 12) to determine whether age-related changes in performance were evident, to gather normative data, and to evaluate the test-retest reliability and criterion-validity of the measure. The results revealed age-related changes in score performance, age-group normative data, an acceptable level of reliability and significant differences in performance of NC and ADHD subjects. Further, discriminant analysis classification rates determined that the TOL(DX) was sensitive and highly specific to ADHD. Implications and limitations of the study are discussed. 相似文献
8.
G. Michelsson Gg. Strassmann Wachholz Marx Weimann C. E. Jancke Zillmer B. Mueller Arthur Schlesinger Autoreferat H. Scholz Breitenecker Schönberg Kittel F. Klauber Kurt Mendel Ranzenhofer Max Michael Jendralski Walcher Schwarz Brieger Fr. Klages Mickenfelder H. Merkel Frenzel 《International journal of legal medicine》1933,21(5):204-216
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10.
Fukutin-related protein localizes to the Golgi apparatus and mutations lead to mislocalization in muscle in vivo 总被引:1,自引:0,他引:1
Keramaris-Vrantsis E Lu PJ Doran T Zillmer A Ashar J Esapa CT Benson MA Blake DJ Rosenfeld J Lu QL 《Muscle & nerve》2007,36(4):455-465
Mutations in the fukutin-related protein gene (FKRP) are associated with a spectrum of diseases from mild limb-girdle muscular dystrophy type 2I to severe congenital muscular dystrophy type 1C, muscle-eye-brain disease (MEB), and Walker-Warburg syndrome (WWS). The effect of mutations on the transportation of the mutant proteins may constitute the underlying mechanisms for the pathogenesis of these diseases. Here we examined the subcellular localization of mouse and human normal and mutant FKRP proteins in cells and in muscle in vivo. Both normal human and mouse FKRPs localize in part of the Golgi apparatus in muscle fibers. Mutations in the FKRP gene invariably altered the localization of the protein, leading to endoplasmic reticulum retention within cells and diminished Golgi localization in muscle fibers. Our results therefore suggest that an individual missense point mutation can confer at least two independent effects on the protein, causing (1) reduction or loss of the presumed glycosyltransferase activity directly and (2) mislocalization that could further alter the function of the protein. The complexity of the effect of individual missense point mutations may partly explain the wide variation of the FKRP-related myopathies. 相似文献