全文获取类型
收费全文 | 2782篇 |
免费 | 105篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 26篇 |
妇产科学 | 44篇 |
基础医学 | 306篇 |
口腔科学 | 25篇 |
临床医学 | 146篇 |
内科学 | 515篇 |
皮肤病学 | 25篇 |
神经病学 | 242篇 |
特种医学 | 432篇 |
外科学 | 496篇 |
综合类 | 17篇 |
预防医学 | 137篇 |
眼科学 | 27篇 |
药学 | 200篇 |
中国医学 | 7篇 |
肿瘤学 | 224篇 |
出版年
2023年 | 7篇 |
2022年 | 16篇 |
2021年 | 46篇 |
2020年 | 19篇 |
2019年 | 28篇 |
2018年 | 61篇 |
2017年 | 42篇 |
2016年 | 69篇 |
2015年 | 47篇 |
2014年 | 62篇 |
2013年 | 109篇 |
2012年 | 142篇 |
2011年 | 196篇 |
2010年 | 93篇 |
2009年 | 74篇 |
2008年 | 165篇 |
2007年 | 188篇 |
2006年 | 163篇 |
2005年 | 179篇 |
2004年 | 178篇 |
2003年 | 169篇 |
2002年 | 182篇 |
2001年 | 42篇 |
2000年 | 52篇 |
1999年 | 51篇 |
1998年 | 49篇 |
1997年 | 35篇 |
1996年 | 35篇 |
1995年 | 39篇 |
1994年 | 36篇 |
1993年 | 22篇 |
1992年 | 35篇 |
1991年 | 38篇 |
1990年 | 25篇 |
1989年 | 27篇 |
1988年 | 31篇 |
1987年 | 19篇 |
1986年 | 16篇 |
1985年 | 24篇 |
1984年 | 14篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1980年 | 11篇 |
1979年 | 7篇 |
1977年 | 3篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1969年 | 4篇 |
1968年 | 3篇 |
排序方式: 共有2900条查询结果,搜索用时 15 毫秒
1.
2.
3.
Transluminal angioplasty of the vertebral and basilar artery 总被引:4,自引:0,他引:4
R T Higashida G B Hieshima F Y Tsai V V Halbach D Norman T H Newton 《AJNR. American journal of neuroradiology》1987,8(5):745-749
Transluminal angioplasty of brachiocephalic vessels for atherosclerotic lesions is now being performed in selected cases. We have thus far treated 17 cases of vertebral artery stenosis and one case of basilar artery stenosis by intravascular balloon dilatation techniques. Clinical presenting symptoms included vertebral basilar insufficiency, repeated transient ischemic attacks (TIAs), and multiple strokes. We performed successful transluminal angioplasty in 16 patients with marked narrowing (greater than 70%) of the dominant vertebral artery from atherosclerosis. One patient with basilar artery stenosis with tandem atherosclerotic lesions was also treated by angioplasty techniques. Repeat angiography at 3- to 12-month intervals has revealed continued patency at the angioplasty site. Complications occurred in our one patient with basilar artery angioplasty, who suffered a brainstem infarction after treatment, and in one patient who had a TIA after bilateral vertebral artery angioplasty. Two other patients had residual vertebral stenosis but remained asymptomatic after the procedure. All other patients who had successful dilatation were asymptomatic at 6 months to 2 years (mean, 15 months) of follow-up. These initial studies indicate that vertebral artery angioplasty may be effective for treating high-grade atherosclerotic lesions and for improving blood flow to the posterior circulation. Angioplasty of the basilar artery is technically more difficult and has a higher degree of risk because of the many perforating branches supplying the brainstem. 相似文献
4.
Carotid cavernous fistulae: indications for urgent treatment 总被引:5,自引:0,他引:5
V V Halbach G B Hieshima R T Higashida M Reicher 《AJR. American journal of roentgenology》1987,149(3):587-593
Angiographic and clinical data from 155 patients with carotid cavernous fistulae were retrospectively reviewed to determine angiographic features associated with increased risk of morbidity and mortality. These features included presence of a pseudoaneurysm, large varix of the cavernous sinus, venous drainage to cortical veins, and thrombosis of venous outflow pathways distant from the fistula. Clinical signs and symptoms that characterized a hazardous carotid cavernous fistula included increased intracranial pressure, rapidly progressive proptosis, diminished visual acuity, hemorrhage, and transient ischemic attacks. Cortical venous drainage from the carotid cavernous fistula is secondary to occlusion or absence of the normal venous outflow pathways and is associated with signs and symptoms of increased intracranial pressure and an increased risk of intraparenchymal hemorrhage. Angiographic demonstration of a cavernous sinus varix, with extension of the sinus into the subarachnoid space, is associated with an increased risk of fatal subarachnoid hemorrhage. Identification of these high-risk features provides a basis for making decisions about treatment. 相似文献
5.
Shinji Hirai Yoshiharu Hamanaka Norimasa Mitsui Masahiko Morifuji Miwa Sutoh 《Annals of thoracic and cardiovascular surgery》2005,11(2):139-141
A 64-year-old man was referred to our hospital with Methicillin-resistant Staphylococcus aureus (MRSA) infection following infrainguinal arterial reconstruction. As repeated MRSA sepsis occurred, we decided to remove the infected graft with distal revascularization via circuitous graft tunneling to avoid serious infections and allow limb salvage. An iliofemoro bypass was performed via an extra-anatomical bypass, from just below the iliac crest into the musculus quadriceps femoris using an 8 mm-ringed polyester gelatin polypropylene tube graft, with complete debridement of a groin infection. Postoperative 3-dimentional CT angiography revealed that the prostheses was patent and the patient had an uneventful postoperative course. We concluded that this extra-anatomical bypass was a safe procedure and an excellent option for patients with an infected vascular prosthetic graft in the groin after previous revascularization, like in our case with no available autogeneous vein grafts. 相似文献
6.
7.
Chieko Nakamura Yoshiharu Kawaguchi Hirokazu Ishihara Hiroshi Sainoh Tomoatsu Kimura 《Journal of orthopaedic science》2004,9(6):629-634
We report two cases of rheumatoid arthritis (RA) with upper thoracic myelopathy and a review of the literature. Clinical data of a 47-year-old woman (case 1) and a 54-year-old woman (case 2) are described. Case 1 showed a transverse-type myelopathy at the T2 segment level of the spinal cord and case 2 had the same type of myelopathy at the T4 segment level. Case 1 had anterior vertebral subluxation of C7 due to marked vertebral collapse and Case 2 had subluxation of T2 with vertebral destruction. These two patients had the mutilating type of RA with multilevel spontaneous fusion in the cervical spine. The lesions in the thoracic spine might be caused by the severe destructive inflammation that is characteristic in mutilating disease. The vertebral collapse might lead to subluxation of the upper thoracic vertebra, resulting in spinal cord compression. Upper thoracic subluxation might be caused by vertebral collapse due to RA and the increased motion as a compensation for decreased mobility caused by spontaneous fusion in the cervical spine. 相似文献
8.
To elucidate the mechanisms of the intracellular signal transduction elicited with bradykinin in NG108-15 neuroblastoma x glioma hybrid cells, we examined the activation of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) by bradykinin stimulation. When the extract of NG108-15 cells was immunoprecipitated with the affinity-purified antibody to brain CaM kinase II, a 50-kDa protein in the immunoprecipitate mainly became autophosphorylated in a Ca2+/calmodulin-dependent manner. The results suggest that the 50-kDa protein is the subunit of CaM kinase II in NG108-15 cells. The Ca2+/calmodulin-independent activity (autonomous activity) of the enzyme increased twice within 10 s by stimulation with 1 microM bradykinin in the cells. The increase in the autonomous activity of the enzyme had two phases: the transient early-peak phase and the long late-plateau phase. The former was abolished by the pretreatment of the cells with 10 mM caffeine or 20 microM BAPTA-AM, and the latter was abolished by the removal of the extracellular Ca2+ with 1 mM EGTA or by the pretreatment with 1 microM nifedipine. Stimulation of 32P-labeled NG108-15 cells with 1 microM bradykinin increased the autophosphorylation of CaM kinase II and this increase was abolished by pretreatment with caffeine or BAPTA-AM. These results suggest that CaM kinase II is activated via the inositol phospholipid signaling pathway induced with bradykinin in NG108-15 cells. 相似文献
9.
Shigenori Inao Yoshiharu Takemitsu H. Edward Conrad 《Journal of orthopaedic science》1996,1(6):369-375
Monolayer cultures of 12-day chick embryo chondrocytes from the regions of dividing (zone 1), elongated (zone 2), and hypertrophied
(zone 3) chondrocytes in the tibial cpiphyseal growth plate were analyzed for their capacity to synthesize types II, IX, X,
and XI collagens. Synthesis of types II and IX collagens was markedly elevated in the zone 2 culture, while type X collagen
synthesis was maximal in zone 3. Type XI collagen was synthesized at low rates in all cultures, with some elevation of its
rate in zones 2 and 3. In terms of mol percent of total collagen synthesis, types II and IX collagens decreased from zone
1 to zone 3, while type X collagen increased progressively. Thus, the composition of the extracellular collagens produced
by the different zones changed markedly during chondrocyte differentiation. In addition, type X collagen was released exclusively
into the culture medium, whereas type XI collagen was retained in the extracellular cell-associated matrix. In contrast, types
II and IX collagens were found in both the culture medium and the cell matrix pools. Although types II and IX collagens showed
similar changes during differentiation, the synthetic molar ratios of these two collagens varied from 3 to 18 in different
cultures, suggesting that the synthesis of these two products is not tightly coupled in these cells. 相似文献
10.
Yoshiharu Kikawa Akio Nakai Yosuke Shigematsu Masakatsu Sudo Kimitaka Kato Shinichi Haruki 《Pediatric nephrology (Berlin, Germany)》1990,4(4):343-344
Leukotriene B4 (LTB4) production in polymorphonuclear leucocytes (PMN) was examined in ten children with steroid-responsive nephrotic syndrome (SRNS) before, during, and after steroid administration. Comparison of LTB4 production was made in 14 children with non-inflammatory disease who were not receiving steroid therapy. No significant change was noted in PMN LTB4 biosynthesis in children with SRNS throughout any phase of the disease. Furthermore, there was no significant difference in LTB4 biosynthesis in PMN between SRNS patients before steroid therapy and patients with non-inflammatory disease. These findings suggest that inhibition of LTB4 production is not involved in the mechanism underlying steroid action in SRNS. 相似文献