全文获取类型
收费全文 | 6865篇 |
免费 | 319篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 223篇 |
妇产科学 | 14篇 |
基础医学 | 1062篇 |
口腔科学 | 230篇 |
临床医学 | 359篇 |
内科学 | 2036篇 |
皮肤病学 | 101篇 |
神经病学 | 418篇 |
特种医学 | 236篇 |
外科学 | 1030篇 |
综合类 | 15篇 |
预防医学 | 160篇 |
眼科学 | 61篇 |
药学 | 401篇 |
中国医学 | 14篇 |
肿瘤学 | 829篇 |
出版年
2023年 | 16篇 |
2022年 | 39篇 |
2021年 | 108篇 |
2020年 | 65篇 |
2019年 | 64篇 |
2018年 | 91篇 |
2017年 | 76篇 |
2016年 | 93篇 |
2015年 | 104篇 |
2014年 | 178篇 |
2013年 | 209篇 |
2012年 | 373篇 |
2011年 | 368篇 |
2010年 | 192篇 |
2009年 | 178篇 |
2008年 | 370篇 |
2007年 | 393篇 |
2006年 | 417篇 |
2005年 | 403篇 |
2004年 | 456篇 |
2003年 | 471篇 |
2002年 | 479篇 |
2001年 | 152篇 |
2000年 | 125篇 |
1999年 | 162篇 |
1998年 | 121篇 |
1997年 | 113篇 |
1996年 | 121篇 |
1995年 | 77篇 |
1994年 | 103篇 |
1993年 | 84篇 |
1992年 | 122篇 |
1991年 | 126篇 |
1990年 | 108篇 |
1989年 | 100篇 |
1988年 | 80篇 |
1987年 | 80篇 |
1986年 | 62篇 |
1985年 | 60篇 |
1984年 | 63篇 |
1983年 | 32篇 |
1982年 | 19篇 |
1981年 | 30篇 |
1980年 | 22篇 |
1979年 | 30篇 |
1978年 | 29篇 |
1977年 | 12篇 |
1976年 | 15篇 |
1975年 | 8篇 |
1973年 | 6篇 |
排序方式: 共有7221条查询结果,搜索用时 31 毫秒
1.
2.
Hidetaro Mori Keisuke Hiraoka Ryoichi Yorifuji Tohru Iwasaki Syuzo Gomikawa Ohshi Inagaki Seishi Inoue Yoshihiro Takamitsu Yoshikazu Fujita 《Artificial organs》1994,18(10):725-728
Abstract: The adsorptive characteristics of 5 dialysis membranes for recombinant human erythropoietin (EPO) were studied in vitro in a closed circuit system. For 120 min, EPO added with bovine serum was significantly adsorbed by polymethylmetacrylate (PMMA) and polyacry–lonitrile (PAN) membranes but not by Cuprophan, ethylene vinyl alcohol (EVAL), or polysulfone (PS) membranes. In addition the EPO adsorptive rate, as well as that of β2 –microglobulin (β2 –MG), was greater with a PMMA membrane than with a PAN membrane. EPO was not detected in the ultrafiltrate at 15 min with 5 membranes. These results indicate that EPO was eliminated by membrane adsorption only with some dialysis membranes. 相似文献
3.
Toru Takahashi Yutaka Hasegawa Kiyohiro Ohshima Taro Nameki Yasuo Morishita 《Annals of thoracic and cardiovascular surgery》2005,11(4):245-248
Although aortic valve replacement (AVR) is an effective treatment for patients with aortic valvular disease, the implantation of a small aortic prosthesis may result in residual left ventricular outflow stenosis and transvalvular gradient. In this study, the outcome in the long-term period of patients treated with a small aortic prosthesis was analyzed retrospectively. Twenty-four patients with AVR were divided into two groups, group A and group B. Group A consisted of 16 patients with 21 mm-sized prosthetic valves, and group B consisted of 8 patients with 19 or 16 mm-sized prosthetic valves. There were no significant differences in preoperative cardiac function or operative procedure in the two groups. The mean follow-up period (months) was 55.0 in group A and 51.3 in group B. RESULTS: One patient died of cerebral infarction in group A. There were no significant differences in cardiothoracic ratio (CTR), left ventricular ejection fraction (LVEF), and left ventricular mass index (LVMI) between the two groups. Postoperative physical activity according to the New York Heart Association (NYHA) classification showed no significant differences in the two groups. Despite using a small prostheses for AVR, the postoperative course was good in the long-term period, although careful follow-up is necessary. 相似文献
4.
R Hattori O Matsuura N Takeuchi J Hashimoto S Ohshima Y Ono S Yamada T Kinukawa K Miyake 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1991,82(5):810-815
As a prospective study on asymptomatic microhematuria, complete urological examinations including cystoscopy, IVP, ultrasound and urinary cytology were performed on 422 patients over 40 years old between January 1987 and December 1988 (group A). The results of group A was compared with that of retrospective study on 266 patients, who had incomplete urological examination between January 1984 and December 1985 (group B). Cystoscopy was performed on 321 patients (87.2%) in group A and on 108 patients (40.6%) in group B. Bladder tumor was found in 10 cases (2.4%) in group A, including 7 cases of male patients (5.7%), but in only 1 case (0.4%) in group B. Since the negative rate of abnormal urinary cytology was 50% and that of abnormal IVP was 90% in 10 cases of bladder tumor in group A, cystoscopy was considered to be an essential examination for the screening of patients with asymptomatic microhematuria over 40 years old patients. 相似文献
5.
Akira Ishih Toshio Miyase Tohru Suzuki Francis W. Muregi Mamoru Terada 《Journal of natural medicines》2007,61(2):213-216
Febrifugine and isofebrifugine alkaloid mixtures extracted from the leaves and buds of Hydrangea macrophylla var. Otaksa, collected during different months, in Japan, were quantified using high-performance liquid chromatography. Leaves collected
during the flowering season, namely from June to August, contained 0.16–0.31 mg/g of the alkaloid mixture, whereas those collected
from September to December had less than 0.03 mg/g of the mixture. However, extracts of buds harvested from October to February
contained a consistently larger amount (more than 0.49 mg/g) of the alkaloids. Hot-water extracts from the leaves and buds
collected during different seasons were evaluated for antimalarial activity against Plasmodium yoelii 17XL in mice. The extract of leaves collected in August demonstrated high antimalarial activity, and all mice that received
the extract survived the infection. In contrast, the extract of leaves collected in December showed little activity. The extract
of buds collected in December cleared parasites, but with subsequent mortality to mouse. The present results show that the
amount of antimalarial agent—febrifugine and isofebrifugine mixture—in H. macrophylla var. Otaksa is both part- and season-dependent, suggesting that the choice of plant parts and their harvesting season are important factors
worth considering in the pharmacological use of medicinal plants. 相似文献
6.
Benign schwannoma of the pancreas 总被引:2,自引:0,他引:2
Labile Togba Soumaoro Kenichi Teramoto Tohru Kawamura Noriaki Nakamura Takahiro Sanada Kenichi Sugihara Shigeki Arii 《Journal of gastrointestinal surgery》2005,9(2):288-290
Reported cases of intrapancreatic schwannomas have recently increased in the literature. However, none of these cases were
diagnosed clearly as schwannoma preoperatively. We herein describe the clinicopathologic findings of a solitary benign schwannoma
occurring in the head of the pancreas. Additionally, the differential diagnosis versus other cystic- and solid-appearing pancreatic
masses is briefly discussed. 相似文献
7.
Yukio Fukuyama Tohru Seki Chikaya Ohtsuka Hisao Miura Michiko Hara 《Brain & development》1996,18(6):144-484
Recent studies have shown that adequate medication can prevent the recurrence of febrile seizures (FS). It has also been clarified that the vast majority of, though not all, FS patients follow a benign course. Then, questions arise as to whether or not FS should be prevented, particularly in light of the risks of side effects from drugs. Which kinds of FS can be prevented, if necessary? The guidelines presented here are aimed primarily at helping general practitioners in considering how to manage FS most appropriately. The guidelines stress that judgements should be individualized, while referring to a few specific ‘warning factors’. The guidelines follow a ‘laissez-faire’ principle for the majority of FS cases, whereas intermittent therapy with diazepam and continuous medication with either phenobarbital or valproate are indicated in other limited cases meeting respective definite criteria. 相似文献
8.
M. Ohshima A. Yokoyama H. Ohnishi H. Hamada N. Kohno J. Higaki T. Naka 《Clinical and experimental allergy》2007,37(5):735-742
BACKGROUND: Enhanced expression of the suppressor of cytokine signalling (SOCS)-5 might be of therapeutic benefit for T-helper type 2 (Th2) dominant diseases, as its expression is reported to result in a reduction of Th2 differentiation in vitro due to the inhibition of IL-4 signalling. OBJECTIVE: To investigate the regulatory role of SOCS-5 in vivo, we explored the phenotype of an experimental asthma model developed in SOCS-5 transgenic (Tg) mice. METHODS: The SOCS-5 Tg mice or wild-type (WT) mice were sensitized and repeatedly challenged with ovalbumin (OVA). We examined bronchoalveolar lavage fluid (BALF), lung specimens, and airway hyperresponsiveness (AHR) to methacholine. RESULTS: The production of IFN-gamma by CD4(+) T cells from unprimed SOCS-5 Tg mice was significantly increased in comparison with unprimed wild-type mice, indicating that SOCS-5 Tg mice have a Th1-polarizing condition under natural conditions. However, in an asthma model, significantly more eosinophils in the airways and higher levels of IL-5 and IL-13 in BALF were observed in the SOCS-5 Tg than the wild-type mice. AHR in the asthma model of SOCS-5 Tg was also more enhanced than that of wild-type mice. OVA-stimulated CD4(+) T cells from the primed SOCS-5 Tg mice produced significantly more IL-5 and IL-13 than CD4(+) T cells from wild-type mice. CONCLUSION: Our results demonstrate that the overexpression of SOCS-5 does not inhibit Th2 response, but rather augments the phenotype of the asthma model in vivo. This finding throws into question the therapeutic utility of using enhancement of SOCS-5 expression for Th2-dominant disease. 相似文献
9.
10.
Usefulness of magnetic motor evoked potentials in the surgical treatment of hemiplegic patients with intractable epilepsy. 总被引:2,自引:0,他引:2
Tohru Kamida Hiroshi Baba Kenji Ono Masato Yonekura Minoru Fujiki Hidenori Kobayashi 《Seizure》2003,12(6):373-378
Five hemiplegic patients with intractable epilepsy were studied with transcranial magnetic stimulation (TMS) before and after various surgical treatments. These patients had unilateral widespread cerebral lesions acquired at various times, including congenital, infantile and childhood injury. Motor evoked potentials (MEPs) of the abductor pollicis brevis (APB) muscles were simultaneously recorded on both sides following TMS of the motor cortex in the respective hemisphere using a figure-8 or circular coil. In all patients with congenital disease, the abolition of motor function in the affected hemisphere was estimated by magnetic MEPs, and the hemiplegia did not deteriorate after functional hemispherectomy (HS) was performed in two of them. In two patients with acquired disease, HS was not performed because it was shown by magnetic maps that the motor function in the affected hemisphere remained. Furthermore, it was shown by electric MEPs using subdural electrodes that a patient who had had encephalitis in early childhood had a reorganised motor area in the parietal cortex of the affected hemisphere. The present findings indicate that magnetic MEPs are a very useful non-invasive method of assessing whether the motor area in the affected hemisphere can be resected in hemiplegic patients with intractable epilepsy. 相似文献