全文获取类型
收费全文 | 18629篇 |
免费 | 941篇 |
国内免费 | 87篇 |
专业分类
耳鼻咽喉 | 131篇 |
儿科学 | 365篇 |
妇产科学 | 140篇 |
基础医学 | 2424篇 |
口腔科学 | 441篇 |
临床医学 | 1202篇 |
内科学 | 4569篇 |
皮肤病学 | 436篇 |
神经病学 | 1301篇 |
特种医学 | 813篇 |
外科学 | 3190篇 |
综合类 | 100篇 |
预防医学 | 529篇 |
眼科学 | 402篇 |
药学 | 1281篇 |
中国医学 | 34篇 |
肿瘤学 | 2299篇 |
出版年
2023年 | 125篇 |
2022年 | 230篇 |
2021年 | 420篇 |
2020年 | 216篇 |
2019年 | 301篇 |
2018年 | 380篇 |
2017年 | 290篇 |
2016年 | 368篇 |
2015年 | 415篇 |
2014年 | 538篇 |
2013年 | 636篇 |
2012年 | 977篇 |
2011年 | 1104篇 |
2010年 | 657篇 |
2009年 | 501篇 |
2008年 | 931篇 |
2007年 | 1029篇 |
2006年 | 999篇 |
2005年 | 1020篇 |
2004年 | 1054篇 |
2003年 | 986篇 |
2002年 | 976篇 |
2001年 | 453篇 |
2000年 | 434篇 |
1999年 | 393篇 |
1998年 | 238篇 |
1997年 | 186篇 |
1996年 | 180篇 |
1995年 | 150篇 |
1994年 | 136篇 |
1993年 | 145篇 |
1992年 | 264篇 |
1991年 | 288篇 |
1990年 | 243篇 |
1989年 | 328篇 |
1988年 | 225篇 |
1987年 | 221篇 |
1986年 | 191篇 |
1985年 | 189篇 |
1984年 | 128篇 |
1983年 | 122篇 |
1982年 | 58篇 |
1979年 | 90篇 |
1977年 | 64篇 |
1975年 | 58篇 |
1974年 | 67篇 |
1973年 | 62篇 |
1972年 | 70篇 |
1970年 | 60篇 |
1969年 | 64篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Eijiro Morita Torao Tanaka Tetsuya Nakamura Fumitaka Terabe Ichiro Hirata Kenichi Katsu Masakazu Takazoe Akira Terano 《Digestive endoscopy》2006,18(4):263-268
Background and Aims: Video capsule endoscopy (VCE) has become increasingly important as a simple method for observing the entire small intestine. The indications for VCE are obscure gastrointestinal bleeding and investigation of Crohn’s disease (CD). However, the correlation between endoscopic findings obtained by VCE and clinical findings in known cases of CD is not clear, and we therefore investigated this in the present study. Patients and methods: In 30 patients with known CD (Crohn’s disease activity index [CDAI] 0–420; median = 158.3), double contrast enteroclysis (ENT) was performed 1–3 weeks prior to VCE. The relationship between the VCE findings and hematological analysis/CDAI was examined. Results: In 17 of 30 patients, the entire small intestine could be investigated by VCE, whereas in the remaining 13 patients the terminal ileum could not be investigated. The following exhibited positive correlations: total lesions and CDAI (correlation coefficient values: rs = 0.661, adjusted P < 0.0061), ulcers and C‐reactive protein (CRP) (rs = 0.607, adjusted P < 0.0061), total lesions and CRP (rs = 0.604, adjusted P < 0.0061). Conclusions: Analysis with VCE suggests that CDAI and CRP indicate the activity of intestinal lesions in patients with known CD, and that CRP, in particular, is associated with the activity of ulcerative lesions of the intestine. This may contribute to revised guidelines for VCE in the future. 相似文献
4.
5.
Experiments were performed on spinalized rats, transected at the Cl level. The intravenous administration of TRH and its analog YM-14673 (N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate) produced marked increases in the amplitude of mono- and polysynaptic reflex potentials and those of the withdrawal flexor reflexes. The effects of YM-14673 were stronger and longer-lasting than those of TRH. The stimulant action of TRH and YM-14673 on the flexor reflexes was not antagonized by prazosin, chlorpromazine, haloperidol or cyproheptadine, suggesting no involvement of the release of catecholamines or serotonin in the stimulant effects of TRH and its analog. Therefore, YM-14673 may be beneficial for the treatment of several spinal motor neuron diseases. 相似文献
6.
7.
8.
Tetsuya Nomura Tatsuya Kawasaki Takuji Tanabe Akihiro Azuma Hiroaki Matsubara 《Annals of thoracic and cardiovascular surgery》2007,13(2):118-121
Mediastinal cystic tumors are well-marginated round lesions that comprise 12% to 18% of all mediastinal masses. These lesions include a variety of diseases with overlapping radiologic appearances and variable prognoses. Pathological examinations are almost always required for differential diagnosis. We encountered a case of anterior mediastinal tumor discovered in the process of investigation of Raynaud's phenomenon. Taking into account the tumor location, a pericardial cyst was initially suspected. However, the tumor was surgically resected and histopathological examinations demonstrated thymus-like tissue in the cyst walls. Raynaud's phenomenon greatly improved after surgery. These findings suggested that cystic thymoma originated from ectopic thymic tissue and is accompanied by paraneoplastic syndrome. 相似文献
9.
T Kato M Itoh J Hanashita T Itoi T Matsumoto Y Ono S Imamura N Hayakawa A Suzuki Y Mizutani Y Uchigata N Oda 《Diabetic medicine》2007,24(11):1279-1281
AIMS: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. METHODS: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. RESULTS: Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. CONCLUSIONS: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy. 相似文献
10.
Tetsuya Ozeki Shuji Beppu Takuto Mizoe Yuuki Takashima Hiroshi Yuasa Hiroaki Okada 《Journal of controlled release》2005,107(3):387-394
In this study, we used a novel 4-fluid nozzle spray drier to prepare composite microparticles of a water-insoluble drug, flurbiprofen (FP), and a water-soluble drug, sodium salicylate (SS), for the purpose of improving the water solubility of FP. An ethanol solution of FP and an aqueous SS solution were simultaneously introduced through different liquid passages in the 4-fluid nozzle spray drier and then spray-dried. Quantitative elemental analysis suggested that the FP/SS ratio in each composite microparticle was nearly the same as the formulation ratio. We also found that SS and FP exist in a low crystallinity state in the composite particles. Release of FP from dissolved composite microparticles was markedly improved because of an increase in the effective surface area following rapid dissolution of SS. This study shows that it is possible to prepare FP-SS composite microparticles using a 4-fluid nozzle spray drier in single process and that this can improve the ability of FP to dissolve in water. 相似文献