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Sonia Fantone Giovanni Tossetta Laura Graciotti Andrea Benedetto Galosi Edlira Skrami Daniela Marzioni Manrico Morroni 《Journal of anatomy》2022,240(5):985
The presence of multinucleated cells has never been demonstrated in renal tissue, although, polyploid cells were recently observed in the tubules of normal and pathological human kidney. Therefore, the aim of the present study is to identify and quantify, by electron microscopy, multinucleated cells in the cortical tissue of normal human kidney i.e., in the three compartments of renal tubule: the proximal tubule (PT), the distal tubule (DT), and the collecting duct (CD), as well as, in the glomerulus (podocytes). The percentage of the multinucleated cells observed was 5% (95%CI: 3.6%–6.7%) in renal cortical tubules with distribution in each tubular compartment of 6% in PT, 4% in DT and 3% in CD with no statistically significant difference in the distribution of multinucleated cells according to tubular compartments. Four percent of analysed podocytes (in total 149 podocytes) were multinucleated (95%CI: 1.5%−8.6%). In conclusion, multinucleated cells were identified and quantified in functionally normal kidneys, as previously demonstrated in other organs such as the liver. 相似文献
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Cameriere Roberto Bestetti Fiorella Velandia Palacio Luz Andrea Riccomi Giulia Skrami Edlira Parente Valentina Ferrante Luigi 《International journal of legal medicine》2019,133(1):197-204
International Journal of Legal Medicine - The aim of this study is to develop a new formula for age estimation in a longitudinal study of a sample from the radiological collection of wrist bones of... 相似文献
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Francesco Barchiesi Elena Orsetti Rosaria Gesuita Edlira Skrami Esther Manso The Candidemia Study Group 《Infection》2016,44(2):205-213
Purpose
We evaluated the epidemiology, clinical characteristics and outcome of candidemia in a single institution from 2010 to 2014.Methods
A retrospective observational study of all cases of candidemia was carried out at a University Hospital in Central Italy including five intensive care units (ICUs), 11 medical and 11 surgical wards. Data regarding demographic characteristics and clinical risk factors were collected from the patient’s medical records. Antifungal susceptibility testing was performed and MIC results were interpreted according to species-specific clinical breakpoints.Results
A total of 270 episodes of candidemia were identified. Overall incidence rate was 1.5 episodes/1000 hospital admissions. Although Candida albicans represented the most commonly isolated species, its percentage significantly decreased from 68 to 48 % (p = 0.040). The overall 30-day mortality was 35 %. The variables independently associated with a significant higher risk of mortality were: older age; being hospitalized in ICU or in medical wards vs surgical wards; being infected with C. albicans vs other species; the occurrence of septic shock, pneumonia and acute renal failure; the presence of a solid organ tumor or a chronic pulmonary disease. Conversely, an appropriate treatment was confirmed to be significantly associated with a lower risk of mortality. The overall resistance was low and it was noted only among triazoles.Conclusions
Our study shows that candidemia is a significant source of morbidity and mortality. The identification of risk factors associated with mortality along with the knowledge of local susceptibility may lead to a better management in terms of preventive and therapeutic measures.5.
Valentino Cherubini Rosaria Gesuita Edlira Skrami Ivana Rabbone Riccardo Bonfanti Claudia Arnaldi Giuseppe D'Annunzio Annapaola Frongia Fortunato Lombardo Elvira Piccinno Riccardo Schiaffini Sonia Toni Stefano Tumini Davide Tinti Paola Cipriano Nicola Minuto Lorenzo Lenzi Lucia Ferrito Claudia Ventrici Federica Ortolani Ohad Cohen Andrea Scaramuzza 《Pediatric diabetes》2019,20(1):107-112
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The role of socio‐economic and clinical factors on HbA1c in children and adolescents with type 1 diabetes: an Italian multicentre survey 下载免费PDF全文
Rosaria Gesuita Edlira Skrami Riccardo Bonfanti Paola Cipriano Lucia Ferrito Paola Frongia Dario Iafusco Antonio Iannilli Fortunato Lombardo Enza Mozzillo Renata Paleari Ivana Rabbone Alberto Sabbion Alessandro Salvatoni Andrea Scaramuzza Riccardo Schiaffini Nicoletta Sulli Sonia Toni Flavia Carle Valentino Cherubini 《Pediatric diabetes》2017,18(3):241-248
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A. Busilacchi M. Olivieri S. Ulisse R. Gesuita E. Skrami T. Lording F. Fusini A. Gigante 《Knee surgery, sports traumatology, arthroscopy》2016,24(7):2124-2132
Purpose
To evaluate the sonoelastographic features of Achilles tendon healing after percutaneous treatment using real-time sonoelastography, a new tool able to quantify deformation in biological tissues.Methods
Patients with atraumatic Achilles tendon ruptures, treated with a percutaneous technique, were assessed. Sonoelastographic evaluations were performed at the myotendinous junction, tendon body/lesion site and osteotendinous junction, both for the operated and contralateral side, at 40 days, 6 months and 1 year after surgery. Using standard regions of interest, the “strain index” (SI) was calculated as an indicator of tendon elasticity. Clinical outcomes were assessed by the ATRS questionnaire at 6 months and 1 year post-operatively and correlated with sonoelastographic findings. Sixty healthy tendons from 30 volunteers were used to provide a healthy control range.Results
Twenty-five patients were recruited for this study. The SI in treated tendons showed progressive stiffening over time, especially at myotendinous junction and at the site of the sutured lesion, resulting in significantly higher stiffness than both the contralateral tendon and healthy volunteers. Peak thickness of treated tendons occurred at 6 months, with a tendency to reduce at 1 year, while never achieving a normal physiological state. Greatest remodelling was seen at the lesion site. The contralateral tendon showed significant thickening at the myotendinous and osteotendinous junctions. The SI of the contralateral tendon was found to be stiffer than physiological values found in the control group. ATRS score improved significantly between 6 months and 1 year, being negatively correlated with the SI (p < 0.001).Conclusion
RTSE showed that operatively treated Achilles tendons become progressively stiffer during follow-up, while the ATRS score improved. From a biomechanical point of view, at 1 year after surgery Achilles tendons did not show a “restitutio ad integrum”. Real-time sonoelastography provides more qualitative and quantitative details in the diagnostics and follow-up of Achilles tendon conditions as the post-operative evolution of the repairing tissue.Level of evidence
Diagnostic and therapeutic study, Level III.8.
Luigi Ferrante Edlira Skrami Rosaria Gesuita Roberto Cameriere 《Statistics in medicine》2015,34(10):1779-1790
Forensic medicine is increasingly called upon to assess the age of individuals. Forensic age estimation is mostly required in relation to illegal immigration and identification of bodies or skeletal remains. A variety of age estimation methods are based on dental samples and use of regression models, where the age of an individual is predicted by morphological tooth changes that take place over time. From the medico‐legal point of view, regression models, with age as the dependent random variable entail that age tends to be overestimated in the young and underestimated in the old. To overcome this bias, we describe a new full Bayesian calibration method (asymmetric Laplace Bayesian calibration) for forensic age estimation that uses asymmetric Laplace distribution as the probability model. The method was compared with three existing approaches (two Bayesian and a classical method) using simulated data. Although its accuracy was comparable with that of the other methods, the asymmetric Laplace Bayesian calibration appears to be significantly more reliable and robust in case of misspecification of the probability model. The proposed method was also applied to a real dataset of values of the pulp chamber of the right lower premolar measured on x‐ray scans of individuals of known age. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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