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排序方式: 共有135条查询结果,搜索用时 15 毫秒
1.
目的:探讨B细胞激活因子(BLyS) 及其受体在多发性骨髓瘤(MM)发病中的作用机制.方法:用酶联免疫吸附测定法(ELISA)和实时荧光定量聚合酶链反应 (RFQ-PCR),对19例MM患者和30名健康人血清BLyS含量、外周血单个核细胞(PBMCs) 中BLyS及其受体mRNA 含量进行检测;并比较MM患者血清BLyS含量与外周血BLyS及其受体基因表达水平和免疫球蛋白(IgG、IgA、IgM)浓度、乳酸脱氢酶(LDH)、轻链(kap、lam)的相关性.结果:MM患者血清 BLyS含量[(7.95±4.93) g/L 明显高于健康对照组[(2.70±1.09) g/L,P<0.01 ,并与LDH浓度呈正相关性(r=0.734,P<0.001);97.4% (18/19),84.2% (16/19)的MM患者PBMCs中BLyS、BCMA mRNA表达水平较正常人明显增高,并且也与LDH的含量呈正相关;而47.32% (9/19)患者TACI mRNA表达水平降低.结论:MM患者的血清BLyS蛋白浓度和PBMCs中BLyS及其受体基因表达水平有异常改变,说明BLyS及其受体可能参与MM的发病;BLyS及其受体表达水平也许可作为预后的一个指标. 相似文献
2.
Breast cancer is the leading cause of cancer death among women worldwide. Accumulating evidence indicates that the local recurrent and/or distant metastatic tumors, the major causes of lethality in the clinic, are related to the aggressive phenotype of a small fraction of cancer cells loosely termed as cancer stem cells (CSCs), tumor initiating cells (TICs), or cancer metastasis-initiating cells (CMICs). Breast cancer stem cells (BCSCs) are shown to exhibit unique growth abilities including self-renewal, differentiation potential, and resistance to most anti-cancer agents including chemo- and/or radiotherapy, all of which are believed to contribute to the development and overall aggressiveness of the recurrent or metastatic lesions. It is in the urgent need not only to further define the nature of heterogeneity in each tumor but also to characterize the precise mechanisms governing tumor–host cross-talk which is assumed to be initiated by BCSCs. In this review, we will focus on recently identified key factors, including the BCSCs among circulating tumor cells, interaction of BCSCs with the host, epithelial mesenchymal transition (EMT), tumor microenvironment, the intrinsic resistance due to HER2 expression, potential biomarkers of BCSCs and cancer cell immune signaling. We believe that new evidence coming from both bench and clinical research will help to develop more effective approaches to control or significantly reduce the aggressiveness of metastatic tumors. 相似文献
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He Yu-Min Zhu Shu Ge Yue-Wei Kazuma Kohei Zou Kun Cai Shao-Qing Komatsu Katsuko 《Journal of natural medicines》2015,69(3):303-312
Journal of Natural Medicines - Gentianae Scabrae Radix is a well-known traditional medicine that is used for the treatment of hepatitis, cholecystitis and inflammatory diseases. It consists mainly... 相似文献
5.
Fan Haoliang Wang Lingxiang Liu Changhui Lu Xiaoyu Xu Xuding Ru Kai Qiu Pingming Liu Chao Wen Shao-Qing 《International journal of legal medicine》2022,136(2):447-464
International Journal of Legal Medicine - Short tandem repeats (STRs) are the preferred genetic markers in forensic DNA analysis, routinely measured by capillary electrophoresis (CE) method based... 相似文献
6.
Na Sun Peng-Cheng Ma Shi Yan Shao-Qing Wen Chang Sun Pan-Xin Du 《Annals of human biology》2013,40(3):261-266
Background: Previous studies have suggested that the human Y-chromosome haplogroup Q1a1a-M120, a widespread paternal lineage in East Asian populations, originated in South Siberia. However, much uncertainty remains regarding the origin, diversification, and expansion of this paternal lineage.Aim: To explore the origin and diffusion of paternal Q-M120 lineages in East Asia.Subjects and methods: The authors generated 26 new Y chromosome sequences of Q-M120 males and co-analysed 45 Y chromosome sequences of this haplogroup. A highly-revised phylogenetic tree of haplogroup Q-M120 with age estimates was reconstructed. Additionally, a comprehensive phylogeographic analysis of this lineage was performed including 15,007 samples from 440 populations in eastern Eurasia.Results: An ancient connection of this lineage with populations in Siberia was revealed. However, this paternal lineage experienced an in-situ expansion between 5000 and 3000?years ago in northwestern China. Ancient populations with high frequencies of Q-M120 were involved in the formation of ancient Huaxia populations before 2000?years ago; this haplogroup eventually became one of the founding paternal lineages of modern Han populations.Conclusion: This study provides a clear pattern of the origin and diffusion process of haplogroup Q1a1a-M120, as well as the role of this paternal lineage during the formation of ancient Huaxia populations and modern Han populations. 相似文献
7.
Fan Haoliang Du Zhengming Wang Fenfen Wang Xiao Wen Shao-Qing Wang Lingxiang Du Panxin Liu Hai Cao Shengping Luo Zhenming Han Bingbing Huang Peiyu Zhu Bofeng Qiu Pingming 《International journal of legal medicine》2021,135(4):1295-1317
International Journal of Legal Medicine - Due to the formation of the Qiongzhou Strait by climate change and marine transition, Hainan island was isolated from the mainland southern China during... 相似文献
8.
Batsukh Zolboo Toume Kazufumi Javzan Batkhuu Kazuma Kohei Cai Shao-Qing Hayashi Shigeki Kawahara Nobuo Maruyama Takuro Komatsu Katsuko 《Journal of natural medicines》2020,74(1):170-188
Journal of Natural Medicines - Saposhnikoviae Radix (SR) is a commonly used crude drug that is obtained from the root and rhizome of Saposhnikovia divaricata which is distributed throughout China,... 相似文献
9.
Kuang SQ Kwartler CS Byanova KL Pham J Gong L Prakash SK Huang J Kamm KE Stull JT Sweeney HL Milewicz DM 《Circulation research》2012,110(11):1411-1422
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