全文获取类型
收费全文 | 4402篇 |
免费 | 210篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 46篇 |
妇产科学 | 69篇 |
基础医学 | 515篇 |
口腔科学 | 49篇 |
临床医学 | 245篇 |
内科学 | 1121篇 |
皮肤病学 | 44篇 |
神经病学 | 359篇 |
特种医学 | 111篇 |
外科学 | 945篇 |
综合类 | 15篇 |
一般理论 | 1篇 |
预防医学 | 61篇 |
眼科学 | 185篇 |
药学 | 358篇 |
中国医学 | 10篇 |
肿瘤学 | 464篇 |
出版年
2023年 | 26篇 |
2022年 | 38篇 |
2021年 | 107篇 |
2020年 | 48篇 |
2019年 | 62篇 |
2018年 | 89篇 |
2017年 | 64篇 |
2016年 | 82篇 |
2015年 | 105篇 |
2014年 | 120篇 |
2013年 | 142篇 |
2012年 | 244篇 |
2011年 | 255篇 |
2010年 | 154篇 |
2009年 | 128篇 |
2008年 | 267篇 |
2007年 | 271篇 |
2006年 | 256篇 |
2005年 | 253篇 |
2004年 | 233篇 |
2003年 | 243篇 |
2002年 | 227篇 |
2001年 | 96篇 |
2000年 | 107篇 |
1999年 | 121篇 |
1998年 | 68篇 |
1997年 | 62篇 |
1996年 | 52篇 |
1995年 | 38篇 |
1994年 | 43篇 |
1993年 | 36篇 |
1992年 | 59篇 |
1991年 | 54篇 |
1990年 | 33篇 |
1989年 | 42篇 |
1988年 | 38篇 |
1987年 | 31篇 |
1986年 | 44篇 |
1985年 | 30篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 25篇 |
1981年 | 13篇 |
1979年 | 25篇 |
1977年 | 13篇 |
1976年 | 13篇 |
1975年 | 13篇 |
1972年 | 14篇 |
1971年 | 12篇 |
1968年 | 19篇 |
排序方式: 共有4634条查询结果,搜索用时 15 毫秒
1.
2.
Kiyotaka YOH Makoto TAHARA Kenji KAWADA Hirofumi MUKAI Masanobu NAKATA Kuniaki ITOH Mitsuhiko KAWASHIMA Hideki NISHIMURA Ryuichi HAYASHI Takashi OGINO Hironobu MINAMI 《Asia-Pacific Journal of Clinical Oncology》2006,2(4):180-184
Background: Olfactory neuroblastoma is a rare sino‐nasal tumor arising from the olfactory epithelium and is often characterized by local invasion or metastasis. The role of chemotherapy in the treatment of this tumor is unclear. The purpose of this study was to review our institution’s experience of chemotherapy for advanced or recurrent olfactory neuroblastoma. Methods: Twenty‐one patients with histologically proven olfactory neuroblastoma were treated at our institution between 1992 and 2002. Twelve of these patients received chemotherapy in the setting of unresectable or recurrent disease and were retrospectively reviewed for clinical characteristics, treatment outcome or survival. Results: Eight patients of the 12 patients received cisplatin‐based chemotherapy and the remaining four patients received chemotherapy consisting of docetaxel plus irinotecan (three patients) or cyclophosphamide, doxorubicin, and vincristine (1 patient). A partial response was achieved in five patients, with an overall response rate of 42%, although the chemotherapeutic regimens were heterogeneous. Two partial responses were obtained among the three patients who received docetaxel plus irinotecan. The response rate to chemotherapy was 83% in the younger age group (<40 years), as opposed to 0% in the older age group (≥40 years), and the difference between the two groups was statistically significant (P = 0.02). Conclusion: Our study indicated that olfactory neuroblastoma would be sensitive to chemotherapy, especially with young patients. Docetaxel plus irinotecan has the possibility of showing favorable response, and warrants further investigation. 相似文献
3.
4.
Y Imamura K Yanagihara Y Fukuda Y Kaneko M Seki K Izumikawa Y Miyazaki Y Hirakata T Sawa J P Wiener-Kronish S Kohno 《The European respiratory journal》2007,29(5):965-968
Pseudomonas aeruginosa is one of the most important pathogens in patients with chronic airway conditions, such as cystic fibrosis and diffuse panbronchiolitis. Type III secretion system-mediated virulence factors contribute to the lung damage in chronic P. aeruginosa infection. The effects of the anti-PcrV immunoglobulin (Ig)G, which blocks the type III secretion system, were evaluated in a mouse model of chronic P. aeruginosa infection. On bacteriological examination, anti-PcrV IgG showed no bactericidal effects. On bronchoalveolar lavage fluid (BALF) analysis, total cell number and neutrophil ratios in the anti-PcrV IgG-treated groups were lower than those in the control group. In addition, macrophage inflammatory protein-2, tumour necrosis factor-alpha, and interleukin-beta concentrations in BALF were lower in the anti-PcrV IgG-treated groups when compared with controls. Plasma anti-PcrV IgG titre was elevated after administration of anti-PcrV IgG. Although plasma titre decreased gradually, a significant concentration was maintained during the experimental period. These data suggest that anti-PcrV immunoglobulin G reduces the inflammatory reaction caused by chronic Pseudomonas aeruginosa respiratory infection and may be useful in treating respiratory diseases. 相似文献
5.
6.
7.
Hironori Nakagami Yasushi Kikuchi Tomohiro Katsuya Ryuichi Morishita Hiroshi Akasaka Shigeyuki Saitoh Hiromi Rakugi Yasufumi Kaneda Kazuaki Shimamoto Toshio Ogihara 《Hypertension research》2007,30(12):1239-1246
We examined a gene polymorphism of a novel Z-disc-related protein, myospryn (cardiomyopathy-associated 5). We focused on one haplotype block associated with a tag single nucleotide polymorphism (SNP) that covered 16 of 27 coding SNPs with linkage disequilibrium (minor allele frequency 0.413). Screening a myospryn polymorphism (K2906N) in a general health check-up of a rural Japanese population revealed an association with cardiac diseases (p=0.0082). In further analysis of the interaction between K2906N and cardiac function in patients, K2906N was associated with the anteroseptal wall thickness of the left ventricle in a recessive model (p=0.0324) and with the ratio of the peak velocity of the early diastolic filling wave to the peak velocity of atrial filling (A/E) (p=0.0278). In an association study based on left ventricular wall thickness, we found a significant difference in the K2906N genotype between controls and patients with cardiac hypertrophy. These results suggest that the K2906N polymorphism could be clinically associated with left ventricular hypertrophy and diastolic dysfunction independent of known parameters. Although the precise mechanism underlying this association remains to be elucidated, treatment with angiotensin II induced an increase in heart myospryn mRNA level in vitro and in vivo. Our results suggest that the polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload. 相似文献
8.
Attenuation of lung injury in allograft rejection using NF-kappaB decoy transfection-novel strategy for use in lung transplantation. 总被引:5,自引:0,他引:5
9.
Satoru Miyawaki Ryuichi Yamazaki Takehiko Harada Shigehiko Takanashi Tadashi Nagashima Hiroshi Nakaguchi Ryo Okazaki Kazuhito Yamazaki Yasuo Ishida Akira Matsuno 《Journal of clinical neuroscience》2007,14(5):481-484
Skull metastasis of thyroid carcinoma is rare. The majority of skull metastases of thyroid carcinoma are of the follicular subtype, rather than thyroid papillary carcinoma. In this report, a 55-year-old woman with skull metastasis from thyroid papillary carcinoma is presented. The metastatic lesion of the skull was hypervascular and osteolytic, and the bleeding was profuse during resection. There have been only four reports of skull metastasis from thyroid papillary carcinoma. The mean period from the initial diagnosis of thyroid carcinoma until the detection of skull metastasis is 23.3 years, whereas in this patient, it was about 2 years. Therefore, in the clinical course of thyroid papillary carcinoma, skull metastasis should be considered, and the patient should be meticulously followed up. 相似文献