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Differential control over cocaine-seeking behavior by nucleus accumbens core and shell 总被引:14,自引:0,他引:14
Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish. Here we show a neural double-dissociation of the behavioral processes that underlie cocaine self-administration in rats. Whereas selective excitotoxic lesions of the NAc core had only a minor effect on the acquisition of responding for cocaine under a standard schedule of continuous reinforcement, these lesions profoundly impaired the acquisition of drug-seeking behavior that was maintained by drug-associated conditioned reinforcers and assessed using a second-order schedule of cocaine reinforcement. In contrast, selective excitotoxic lesions of the NAc shell did not impair drug self-administration or the acquisition of cocaine-seeking, but they did attenuate the psychostimulant effects of cocaine. These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior. 相似文献
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Yamaguchi Rutsuko Makino Yohsuke Chiba Fumiko Torimitsu Suguru Yajima Daisuke Inokuchi Go Motomura Ayumi Hashimoto Mari Hoshioka Yumi Shinozaki Tomohiro Iwase Hirotaro 《International journal of legal medicine》2017,131(6):1655-1663
International Journal of Legal Medicine - To determine the frequency of cardiopulmonary resuscitation (CPR)-related injuries and factors involved in their occurrence, data based on forensic autopsy... 相似文献
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Bilgehan avdarolu Jeffrey Toy Anett Schumacher Gabriel Carvalho Mihilkumar Patel Rutsuko Ito 《Hippocampus》2020,30(9):913-925
The acquisition of active avoidance (AA) behavior is typically aided by the presence of two signals—the warning signal, which predicts the future occurrence of an aversive event (e.g., shocks), and the safety signal, which is presented upon successful avoidance of oncoming shocks. While the warning signal could be conceived to act as a Pavlovian fear cue, and is likely mediated by brain areas that underlie Pavlovian fear cue conditioning, the neural substrates underlying safety signaling are less clear, largely due to the unavailability of AA tasks that are devoid of an explicit warning signal. The present study sought to investigate the role of the ventral hippocampus (VH) in safety signaled AA performance acquired without an explicit warning signal, using a novel discrete trial paradigm. Adult male Long Evans rats were divided into two groups and trained to acquire AA responses with, or without a safety signal. Analysis of the acquisition and stable state performance data revealed that the availability of a safety signal alone did not improve the acquisition or performance of AA responses. Furthermore, post‐training, reversible VH inactivation did not impact stable state avoidance behavior. However, extinction of avoidance responses was facilitated in the group trained with a safety signal, and this effect was further potentiated by VH inactivation. Additional elevated plus maze (EPM), light–dark box, and locomotor tests demonstrated that VH inactivation reduced anxiety without affecting locomotor activity. Taken together, these results demonstrate the importance of VH in the extinction of persistent pathological avoidance behavior when safety is signaled. 相似文献
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Hisashi Nagai Akina Nara Rutsuko Yamaguchi Ken-ichi Yoshida Koichi Uemura 《The Australian journal of forensic sciences》2016,48(2):132-137
We report a fatal case of acute subdural hematoma (ASDH) involving the delayed onset of subdural bleeding after a head trauma. There were no central nervous symptoms after the head trauma and an initial head computed tomography (CT) scan did not exhibit any abnormal findings. On the second day, the patient suddenly complained of a headache and vomiting, and she lost consciousness. An emergency head CT scan detected a right-sided ASDH and severe cerebral herniation. As the patient was taking triple anticoagulant therapy, surgery could not be performed. She died 2 weeks after the onset of the ASDH. Even in cases of head trauma that do not exhibit abnormal findings on head CT, it is necessary to follow up the patient’s clinical condition. Specifically, controlling coagulability and performing repeated head CT examinations are considered to be beneficial for preventing abundant subdural bleeding and facilitating the early detection of delayed onset ASDH. 相似文献
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Kira Kei Chiba Fumiko Makino Yohsuke Torimitsu Suguru Yamaguchi Rutsuko Tsuneya Shigeki Motomura Ayumi Yoshida Maiko Saitoh Naoki Inokuchi Go Hoshioka Yumi Saitoh Hisako Yajima Daisuke Iwase Hirotaro 《International journal of legal medicine》2023,137(2):359-377
International Journal of Legal Medicine - Stature estimation is one of the most basic and important methods of personal identification. The long bones of the limbs provide the most accurate stature... 相似文献
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Bilgehan avdarolu Sadia Riaz Elton H. L. Yeung Andy C. H. Lee Rutsuko Ito 《Neuropsychopharmacology》2021,46(3):632
Approach-avoidance conflict is induced when an organism encounters a stimulus that carries both positive and negative attributes. Accumulating evidence implicates the ventral hippocampus (VH) in the detection and resolution of approach-avoidance conflict, largely on the basis of maze-based tasks assaying innate and conditioned responses to situations of conflict. However, its role in discrete trial approach-avoidance decision-making has yet to be elucidated. In this study, we designed a novel cued operant conflict decision-making task in which rats were required to choose and respond for a low reward option or high reward option paired with varying shock intensities on a differential reinforcement of low rates of responding schedule. Post training, the VH was chemogenetically inhibited while animals performed the task with the usual outcomes delivered, and with the presentation of cues associated with the reward vs. conflict options only (extinction condition). We found that VH inhibition led to an avoidance of the conflict option and longer latency to choose this option when decision-making was being made on the basis of cues alone with no outcomes. Consistent with these findings, VH-inhibited animals spent more time in the central component of the elevated plus maze (EPM), indicating a potential deficit in decision-making under innate forms of approach-avoidance conflict. Taken together, these findings implicate the VH in cue-driven approach-avoidance decisions in the face of motivational conflict.Subject terms: Motivation, Limbic system 相似文献
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Ito R Robbins TW McNaughton BL Everitt BJ 《The European journal of neuroscience》2006,23(11):3071-3080
The hippocampus and amygdala are thought to be functionally distinct components of different learning and memory systems. This functional dissociation has been particularly apparent in pavlovian fear conditioning, where the integrity of the hippocampus is necessary for contextual conditioning, and of the amygdala for discrete cue conditioning. Their respective roles in appetitive conditioning, however, remain equivocal mainly due to the lack of agreement concerning the operational definition of a 'context'. The present study used a novel procedure to measure appetitive conditioning to spatial context or to a discrete cue. Following selective excitotoxic lesions of the hippocampus (HPC) or basolateral amygdala (BLA), rats were initially trained to acquire discrete CS-sucrose conditioning in a Y-maze apparatus with three topographically identical chambers, the chambers discriminated only on the basis of path integration. The same group of animals then underwent 'place/contextual conditioning' where the CS presented in a chamber assigned as the positive chamber was paired with sucrose, but the same CS presented in either of the other two chambers was not. Thus, spatial context was the only cue that the animal could use to retrieve the value of the CS. HPC lesions impaired the acquisition of conditioned place preference but facilitated the acquisition of cue conditioning, while BLA lesions had the opposite effect, retarding the acquisition of cue conditioning but leaving the acquisition of conditioned place preference intact. Here we provide strong support for the notion that the HPC and BLA subserve complementary and competing roles in appetitive cue and contextual conditioning. 相似文献